Thyroid Hormone Resistance - Info

[ASkepticalConsumer]

Hello everyone:

Thanks to the administrators and all the dear folks that assist the public on this GREAT site.

I came across this article and it is excellent in explaining a very overlooked cause of people taking medicine but still having symptoms (like me). And of course, being ignored and dismissed by big pharma doctors.

restartmed.com/thyroid-horm...

It got me thinking because I still have mold in my body due to a moldy house and Candida as well, it is probable that the 100 mg of Synthroid and 5 mcg of Cytomel are making no difference to me. My free T4 is less than 1/3 of the range and the free T3 is at the very bottom of the range. I have Hashi's.

The approach - treatment to the elimination of symptoms is recommended.

Hope this assists the dear folks on this board.

Kindest Regards To All

[DippyDame]

As someone with RTH I agree , this is a good review.

I had to self diagnose and I succesfully self medicate with a supraphysiological dose T3-only....after almost a lifetime of symptoms.

My journey is explained in my TUK bio

It is not an easy road to navigate .....

[arTistapple in reply to DippyDame]

Dippy can I just say I tried but obviously still did not grasp the wholeness of what you have been telling me. This piece has further enlightened me; no doubt due to the specifics of the symptoms I now find myself left with. I think being let down by medics time and time again maybe makes us ‘resistant’ to some sources of help. It’s nothing at all to do with the quality of your information and much more to do with our disappointing brush with NHS style medicine. It’s just great you are there with your experience and frankly huge bravery, contributing to this forum.

I wonder if there is a clue in the word ‘resistance’ in thyroid treatment? Certainly I am obviously much more obstinate than I thought. Luckily I keep ‘getting over myself’. Thank you.

[DippyDame in reply to arTistapple]

"Resistance" refers to the fact that in people with RTH the T3 mets resistance as it tries to enter the cells from the serum....which of course results in low cellular T3.... and as we know low cellular T3 causes multiple problems in the body.

To overcome that resistance we need to use "a battering ram" in the form of a supraphysiological dose of T3 to create a force strong enough to overcome said resistance and to help push some of the large dose into the cells where it can attach to T3 receptors....and so on

Frankly I would also use " resistance" to describe medics attitude to this issue.....there are none so blind as those who will not see!

It is a long slow journey.....over 6 years since I introduced T3 and today I'm feeling rather pleased with myself( OK smug!!) because in the last couple of days I've experienced another improvement.

In my case sheer bloody mindedness pushed me on!!! I was determined to prove I was right....and to feel better.

It is a good article....I have read it before, I found the link in my messy files yesterday...and was delighted to be reintroduced to it.

We are all very different so my journey will vary slightly from that of others

It is a scandal of monumental proportion and, I'd alledge, tantemount to medical neglect

Keep pushing on

In haste

DD

[arTistapple in reply to DippyDame]

“Sheer bloody mindedness”! Obviously under our circumstances a definite positive.

[arTistapple]

This guy is one of the first sources I came across after diagnosis of hypothyroidism. I feel certain I have therefore read this before. Whilst this describes my situation (plus the extra reading about fibro etc) my thinking is that I was unable to differentiate between my many acquired symptoms and what was happening to me at the initial time of reading it. Having been sporty when younger, an avid gym ‘partaker’ and house renovator (even into my late sixties), I must have grown used to a lot of muscle pain. It’s only fairly recently I have thought of it as a specific problem. DippyDame has brought this type of hormone resistance to my notice before, for which I am grateful. More info, more pieces of the jigsaw and from a newly acquired perspective of feeling a bit better (due to not messing about with my meds for some months) perhaps allowing me to see more clearly what my symptoms are! Thank you for this further most helpful pointer rereading it has allowed me to become aware that it applies directly to me! AND gives me further confidence in my route towards T3.

This is a remarkable forum.

[DippyDame in reply to arTistapple]

I understand what you mean by confusing symptoms....for quite a long time I couldn't make progress until I unravelled things and discovered that it wasn't my T3 dosing that was the problem but the development of Chronic UTI which knocked me for six. It's still being treated but there is light at the end of that tunnel too ....after years of unidentified cuti symptoms ....now trying yet another antibiotic! I'm sure the cuti is the result of long term low cellular T3!

Thyroid disease has many issues still to be understood and accepted!

To quote Hamlet, "There are more things in heaven and earth, Horatio ( read medics!), than are dreamt of in your philosophy”

[arTistapple in reply to DippyDame]

Yes there is a sense that there are always maybe underlying issues causing/or at least keeping thyroid symptoms going. Eventually (maybe) these will be more fully unravelled; if there is any interest in medical circles. At the moment we are very much left to our own devices and the forum fulfils that need for knowledge. Another thing learned and not to despair about is that things do not necessarily stay the same forever - even if you find a suitable ‘sweet spot’. However symptoms can continue to improve, our health gets more generally better and things change. I particularly like when experienced contributors like yourself to the forum highlight this. It shows how dynamic it all is, once it gets going!

[ASkepticalConsumer]

The OP here.

Great responses folks, and I feel fortunate to have this analysis.

I am not sure Synthroid is the tool for me, given my body Candida and Mold.

The T3 seems to be the weapon to improve my health and get the free T3 into the top 1/3 of the range. But might need a big dose increase.

I am in Canada and have no family doctor (there are none), so I am relying on a Nurse Practitioner in a Naturopathic clinic, but these clinics are under attack by the MD's. So I might have to go to the US for service.