I received Grossman Cynomel in December. These are the ‘new’ batches, after the period of scarcity in availability.
The tablets are larger than they used to be. In the 5 or so weeks that I’ve been taking it, I have had the return of some old hypothyroid symptoms, including carpal tunnel and oedema, along with more morning fatigue.
Did anyone else receive the new batches? Are your tablets larger, compared to previously. Is everyone else doing ok on the new batches?
Many thanks,
M xx
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Ihave3kids
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My new batch is in the post! I've already got some with a bb date of June 2022 and October 2023 and they're different sizes, but I haven't noticed any difference in their effect.
Thanks for replying! Ok, good to know. If I can ascertain that most others are responding as usual to the new batches, then that rules out any formula changes and I can then assess other things that could be causing my increase in symptoms.
When I get back from work I will measure them and post measurements here. They are noticeable bigger. They were very small before, so I’m glad they are a bit larger.
I am a little surprised 5mm tablets, which I feel are a fairly small tablet, were once even smaller! I have taken this for years & can only remember tablet being about 5mm, scored on one side with no marking on other side. Those using at present from before recent shut down of production so older stock, are just the same and they are fine. I haven’t had any ‘new stock’ yet though
We've just taken delivery of a new batch from Mexico (Cynomel - Grossman brand). They're definitely the same as the previous batch (expiry date October 2023 and Lot No. 367141). The size is 5mm (definitely no larger), scored on one side and unmarked on the other - Lot No. 403707, expiry date October 2024. That expiry date is a lot closer than we expected which suggests that it may be stock that's been sitting on a shelf for some time.
I bought Mexico Cynomel in 2016, and they were good for me. After the battle in Norfolk to get T3 reinstated, I've got mine on NHS since 2020, but I'm always wary.
So I ordered more Cynomel 2 weeks ago. Nothing arrived yet, but I'll let you know ...
Thank you. I wonder if they’ve lost potency. I’m going to order more. In the meantime, I do have access to Thybon Henning, which I’m having to double the dose of, as I’ve used it before and found it very weak compared to Grossman.
If possible, can you also take a photo of the tablets and packaging to post here please. And add details of batch number/s too. Fake medications are always a concern, especially when purchasing from overseas.
Presumably Nov 23 is the expiry date. That seems shorter than it used to be (although I might be misremembering!). Don't suppose you have any information about the excipients? I know this brand didn't previously come with any PIL in the box or ingredient list on the bottle. But it seems not unlikely the ingredients may have changed if the tablets are bigger.
No; no leaflet or box. I have tried several brands of T3 and Grossman was by far the most effective for me personally.
I’ve been on the new tablets for about a month now and honestly, I’m beginning to feel awful. It could be something else but over the years I have become very astute at monitoring my own symptoms and signs.
Last time my T3 levels dropped, was when I trialled Thybon Henning on the advice of an endo. Similar issues then. My T3 tanked, I knew it had and it was confirmed by blood tests. This is what I’m experiencing now - I’m almost certain of it.
I hope everyone else gets on with the new batches ok and that I’m an anomaly. This is no fun. I’d finally started working again after being too poorly to. My whole life changed when I found a T3 that suited me.
If anyone knows of any other good alternatives, please PM me.
If those really are new Grossman Cynomel tablets, they very definitely have changed the formulation. Even if it's only to double up on excipients to make those (relatively) huge tablets.
Agreed. I’m going to experiment with a full tablet, instead of half. I’ll soon tell. Alteration of fillers, does affect me. I’ve had to increase dosage in the past to compensate.
You could contact Laboratorios Grossman, S.A. who are part of Bausch Health (formerly Valeant Pharmaceuticals International, Inc.) or any pharmacy which supplies the product.
I have not yet found the information posted anywhere - I only have old documents.
Bausch Health's website for Mexico doesn't work at all.
The Bausch Health website you list - they can’t assist with enquires on Grossman product or advise on Grossman contact email address. Looking up Laboratorios Grossman S.A. on web for email address has so far only listed the Canadian Bausch Health as email contact. I’ll keep looking…
I’d have thought if it were old stick, that the tablets would have smaller, like they previously were. Someone else in this thread, said their new batch tablets were larger.
It would be really useful if someone could let us know what the mm size of the ‘smaller’ Cynomel tablet is please, so can be compared to the 5mm size Ihave3kids has received from the new stock. These would be the Cynomel tablets from before shut down production last year.
Also apart from score mark on one side, if theirs has any markings on other side.
I don't think the picture posted by Ihave3kids shows a 5mm tablet. I think it looks like 7mm. The left edge is to the left of the end of the ruler scale.
Yes, I can see that now Helvella, so about 7mm in size. Whichever pharmacy supplies, this Mexican Cynamel is produced at the same manufacturing plant, so I can’t see why there should be any variation is size or perhaps effectiveness. And again, it would be interesting to know what the mm size of the pre or post 2022 shutdown Cynomel tablets are, from anyone who believes they are smaller to those photographed above. Also, this medication comes boxed, presumably from the manufacturer, has anyone else received Cynomel unboxed as Ihave3kids has? I & she have no other markings on our tablets other than a score mark. I can’t find any photo of tablet on web search, so presume this is how they are. (Mind you, I thought medication had to have a stamp mark on to identify).
I don't know if this is any help but I bought some Grossman Cynomel back in 2017 from the popular/reliable Mexican source. I tried them and found them much stronger (for me) than the other brand I'd been using so I stopped them and went back to my original brand. I still have one unopened bottle (I can't remember what I did with the bottle I started to use). I have checked them and can clearly see that they are scored on one side, nothing on the other side, and they measure 7mm. I'm not going to open the bottle (keeping them sealed so that I have an emergency stock in case I can't get my regular T3 at any time) but it was easy enough to measure them and see if there are any markings.
another member contacted me & thought new stock of Cynomel might be stronger. Has admin received any other queries in new stock ? You have to be so careful with meds don’t you
Unfortunately, I used every last tablet of my previous supplies. If anyone out there has the smaller tablets, would you please be able to verify size please?
I really don’t think that my new batches are fake. I have been using this very popular and reliable supplier for years now.
For me personally, this new batch is ineffective and I’m becoming more and more hypo as the days progress and it is an awful, sinking place to be in.
I’ve woken this morning with swollen, tight eyelids and the feeling that I’m dragging through treacle. Symptoms that have been unfamiliar to me for at least the last year.
I have had the odd blip in the past but I haven’t seen swollen eyelids, generalised oedema - including my engagement ring not fitting any more (!), carpal tunnel, tinnitus and dreadful morning fatigue, for a long time now.
Couple that with the very definite change in tablet size and it leads me to only one conclusion; change in formula.
I hope I’m wrong. I wouldn’t like to hear of others going through what I’m experiencing now. I’d rather it just be a personal blip than that.
Any more input when members receive their new supplies would be most welcome.
Any PM’s welcome if any members are able to point me in the direction of older stock or have any advice as to other brands. I used to take Tiromel and have tried Thybon Henning. Tiromel was better than Thybon but nowhere near as effective as Grossman for me. Grossman changed my life. I’d previously had a diagnosis of M.R. before that. Grossman allowed me to work and swim again and I’d maintained that level of health more or less for 2 years.
The problem, as I see it, is that the pharmacy may be getting their supplies in the same way as ever. But what if it is within the distribution chain that any fake is being channelled? So all the documentation (shipping note, invoice, etc.) that the pharmacy gets looks fine.
The pharmacy gets their usual supply and sends it out. They won't be testing. At best, they'll be checking the labels.
Yes, I suppose there are so many possibilities. It’s quite frightening to consider. I’m still hoping that it’s ‘just me.’ I suppose only time will tell.
hi, i've heard that the distribution of the product in the pills is uneven in some so u can try powdering the pill & then separating it into your doses. i hope that works for u.
Hi all, I just returned from Mexico a couple of weeks ago and I thought I'd bought the last 2 boxes available! (I went from chemist to chemist asking for it). I have "old" stock with an expiry date of 2020. I've had a look and both bottles are exactly the same, same information, etc. As to the tablets, the older ones are just minimally smaller. Barely noticeable to the eye.
The only difference I could see, but I cannot quite photograph as they are so small, is that the old ones are kind of bevelled on the edge, whereas the new ones are flat.
Still, in Mexico they kept telling me they were out of stock. Someone called the lab and they told them there were supply issues and could not know when, if ever, production would resume, so I'm somewhat surprised people got them here in the UK at around the time I was desperately looking for them in Mexico.
I'd love it if someone could share their supplier via pm.
Very interesting. I’ve just ordered and received (today) another batch from the same company, hoping to get a different batch number but they are same unfortunately. Same number, same expiry date of Nov 23.
I’ve also ordered from a different company and am awaiting delivery. I’ll keep updating as and when!!
I am am in the same boat as you... I received a newer batch with the larger pills and just not finding them effective. I think it might just be a matter of different body sensitivities. If anyone has an older batch with the smaller pills with the bevelled edges, I'd be up for a swap of these newer ones if you find them effective.
Exactly same as I’ve found. I even ordered second lot, hoping for different batch number and they arrived this morning but same batch number and expiry date, so I’m assuming they will be less effective too.
I’ve also ordered through a different company and am awaiting those. I’ll keep you updated.
I too, would love to access older batches. I was too poorly to work until I started on Armour plus additional cynomel. Grossman worked so well for me and was superior to other brands - for me.
I’m a lot more tired and have return of oedema. I work with children and I had to do an Ofsted this week while brain fogged and tired. I really need to find older batches or I’m going to end up back to square one, I fear.
Sorry to hear you didn't have any luck getting a different batch. I'm glad you found a workaround with the Armour at least, although it still doesn't sound ideal for you. Keep us posted on how you're doing.
Did you try yet taking the entire pill? I too am feeling some hypo symptoms since taking this, but I’ve never taken it before & have no comparison. I liked Tiromel, but I lost my supplier. I am thinking about taking the entire Grossman Cynomel 25, but haven’t yet.
Hi -I ordered some cynomel that came with the exp date cut out. I was suspicious and emailed the vendor who gave me a long confusing explanation. Anyway, I finally started using from that bottle and immediately became hypo. I then switched to another bottle from a different delivery with the 11/23 expiration date (larger pill) and I’m still feeling hypo. Did you ever figure out what was going on with that batch?
I managed to source an older supply and seemed to be doing ok on it but my recent results are a bit squiffy. I did not do well on the newer batches of Grossman and I tried taking a whole pill, like you!
Thank you for the reply. It’s so strange that the Grossman t3 has this problem. I don’t get it. I’m going to try tiromel and linorma from another source. Fingers crossed! Good luck to you.
I used to use Tiromel before Grossman. Found it weaker than Grossman but you could always compensate for that by taking slightly larger dose. It would be my second choice after Grossman but we are all different!
I just stumbled on this thread was about to order more Mexican T3 as back up and can only seen Tryotex make on the usual site I would order from. Only 10 mcg or 75 mcg on sale, and not sure how I would split the 75, so would be expensive if I got the 10, and sounds as if not effective anyway . I have 3 pots of the Grossman stuff stashed away, but 2 expire in Aug, and one in Oct, and my storage wasn't A1 at one point, due to moving house last year, and it was hot at that time. I am about to try the Aug batch.
I am lucky enough to get NHS T3 monotherapy, but have recently been given Teva which makes me feel dreadful, and now cannot easily obtain Morningside which I am very good on, so I am trying to sort this latest issue out as I only have 3 boxes left of that and I am on 50 mcg per day. Boots are trying for me non Teva, but I don't know how the alternatives will be, IF I manage to get anything.
It’s a minefield. I’m actually prescribed Thybon but it’s useless for me so I source my own Grossman. I’ve never heard of Morningside. It would be easier if I could use what I’m actually prescribed. I do sympathise with you. I wish there wasn’t so much difference between brands.
I didn't know that Grossman was still available, as I couldn't see it on the site that I used to order it on (online via Mexico). Also I had read that it had changed and not effective for some - but OK for you it seems? Pharmacies just don't want to treat us as individuals, and accept that fillers can affect us all differently.
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