Study suggesting reasons why some patients remain insufficiently treated

[diogenes]

Prevalence and predictors of adequate treatment of overt hypothyroidism - a population-based study

January 2022

EXCLI Journal 21:104-116 

DOI: 10.17179/excli2021-429

1Julie Lindgård NielsenJesper KarmisholtInge Bülow PedersenAllan Carlé

This paper relies totally on TSH as the guiding factor in determining adequate treatment. Its only value is to show that some groups of patients take more time to achieve "adequate" treatment than others. They still ignore FT3 totally. Note:: because of the random nature of patients studied only a minority will fall under the case of inadequate conversion og T4 to T3. These will be swamped out by the majority, so one shouldn't take this study seriously in that regard.

[humanbean]

Link : researchgate.net/publicatio...

If you scroll down you can read the entire paper on that link or you can download it as a PDF file.

Not only doesn't it mention T3 / liothyronine / triiodothyronine it also doesn't mention Free T4. They used Total T4 instead.

*rolls eyes *

[LindaC in reply to humanbean]

Thank you so much!

[Charlie-Farley]

Hi diogenes

oh dear so that will be more bad science- follow the money. ☹️

[diogenes Remembering in reply to Charlie-Farley]

Yes, I think it's useful occasionally to highlight papers such as this, as it emphasises the amount of work needed to change understanding. Hopefully these sorts of papers will diminish in future.

[Charlie-Farley in reply to diogenes]

Very true

And it directly pushes back on the research that’s daring to step out of line and shine a light on the flawed science.

It’s frustrating to see people quickly jumping on a bandwagon to get papers under their belts. I see no other reason for it. After all if they did there research they would see there was a more convincing set of markers for health than TSH. Just on first principles, it is flawed by virtue of it being an indirect measure, before you even get onto the whole miriad of reasons why in a particular situation the relationship between TSH and thyroid response may breakdown. I’ve been reading on and off for two years nearly and I’m still agog- it like a ‘kings news clothes ‘ of medicine.

. I have seen first hand how people knock out paper after paper, not particularly good science, nothing new, subtly avoiding addressing any weakness in the methodology. …. And it gets a free pass through peer review and output secure s more funding 🙄

[mfinn]

Diogenes. Do you ever feel tempted to contact people who produce nonsense like this and tell them where they're going wrong?

[diogenes Remembering in reply to mfinn]

No: the reason is that they will do one of two things: most likley ignore me, and additionally double down on their belief. It's THEY who have to admit error and change accordingly. They can easily brush me off by rubbing in my non-medical background.

[mfinn in reply to diogenes]

Yes, unfortunately you’re right. It was a silly question.

[Charlie-Farley in reply to diogenes]

Ooo non medical? Then fresh eyes and not indoctrinated with the same bo!!@cks that the others suffer from. This is a bonus not a disadvantage if one likes scientific rigour. This is why I loved studying Environmental Science, which, at its best is all about different disciplines coming together to work on problems actually using those different perspectives in problem solving. It opens the mind. Mind you, it is perfectly possible to fall down the academic ‘rabbit hole’. Yep, earthworms, contaminated soil and measuring microbial activity using radio labelled compounds to measure microbial respiration. Yep big knacking rabbit hole! 😂 good fun though 😉👍