Glutathione

[arTistapple]

Has anyone tried using this cream on the soles of your feet as per Datis Kharrazian?

Seen it also as rubbing on skin over liver.

[greygoose]

What's it supposed to do on the soles of your feet?

[arTistapple in reply to greygoose]

Ah this person states that it is one of the very first ‘steps’ to thyroid health. It’s to get the immune system working more efficiently. I think my thyroid is probably very nearly dead but was thinking about the other auto immune illnesses that hypothyroidism seems to be related to. The book is “Why do I still have thyroid symptoms”. I can only find reference to its use as a skin lightening product. Can’t find any other medicinal references.

[greygoose in reply to arTistapple]

It's something I know nothing about, so was interested to learn more. But, my thyroid is dead, so a bit late to worry about thyroid health! lol Not sure I could reach the soles of my feet, anyway, to rub it on.

I don't think hypothyroidism is actually related to other autoimmune disease. It's just that if you have one AI disease, you are likely to develop others. But, I have Hashi's, and have never developed another AI disease, and as I'm now 77, I doubt I will. I think it's just an assessment of risk, rather than an association.

[arTistapple in reply to greygoose]

I feel the same. I think I have had this Hashi’s a minimum of 25 years but actually it could go back to my teens. I will be honest, it looked like an easy thing to do (maybe except the bending down thing) and anything I can do to help myself….. it’s pretty expensive and I am not even sure I have tracked down the correct stuff. You have just saved me £60. Thank you.

[greygoose in reply to arTistapple]

You're welcome. 🤣

[Bob00752 in reply to greygoose]

Thanks for this greygoose. I’ve struggled to understand what the media mean by autoimmune disease. Think I’m Hashi’s too which seems to be an “over exuberant” (other adjectives are available) response by your body which gradually kills your thyroid. Your assessment rather than association view of risk is very helpful.PS my DSN (Diabetic Specialist Nurse, I’m type 2 so not autoimmune) advises me to use an emollient cream to moisturise my feet. I use cheapish creams, mostly paraffin wax based and they seem to help (definitely not £60 a tube or tub!) Plus you get a free stretching exercise - I can just reach, but that might change over the next years…..

[greygoose in reply to Bob00752]

Glad you found it helpful.

[ICE187 in reply to arTistapple]

Here is one on Walnut Oil rubbed on the neck. Not sure if it works, but his followers seem to praise him.youtu.be/k77F184hi5g(Not working as expected?)

[helvella Administrator in reply to ICE187]

If you view that video on YouTube, you will see the long list of affiliate links. And links to his other videos which often have even longer lists of affiliate links.

That is why it exists. Not because he is trying to help us.

[ICE187 in reply to helvella]

Ahhh, makes sense. Well he got me because I ordered Walnut Oil lol. I'm not at a loss as I can cook with it

[helvella Administrator in reply to ICE187]

At least most of his links are to Amazon in India. If that's where you bought from, it might take a while to arrive.

{I'm sure you didn't. Just trying to keep light in tone.)

[ICE187 in reply to helvella]

I ordered it from the U.S. He won't get paid for it lol.

[1tuppence in reply to ICE187]

Walnut oil is a delicious salad oil when added to blackberry/blackcurrant vinegar

[HowNowWhatNow]

No I have not.

When I Google this person Datis’ name - feeling sure I’d read it before - the first thing Google shows me is his name with the word “quack” after it.

Am not sure he is a medical doctor either.

Know no more about him than this, from my first cursory bit of research.

[arTistapple in reply to HowNowWhatNow]

Well something else odd. There have been umpteen updates on the book “if buying second hand be aware that they do not have the latest information contained”. In the end it’s a bit of a PR stunt I think. I think I thought I was buying “Stop the Thyroid Madness”. No wonder I have not bothered too much with it. It’s just I have been glued to the couch for a couple of weeks and I just have to do something!

[HowNowWhatNow in reply to arTistapple]

That’s a shame!

[radd in reply to arTistapple]

arTistapple & HowNowWhatNow ,

Datis Kharrizian is one of the most forward thinking functional doctors leading the field and has been for many years. In additional to his books he used to offer much free advice on the internet but over the last few years has removed it in favour of people paying large fees for expensive courses. He is also not a dedicated thyroid specialist but more generalised.

The reason his books keep being republished is because of the huge advances in functional medicine evidenced by the amount of research and papers now published. His knowledge is second to none in the functional field but I am saddened by his unscrupulous methods to obtain more money from unwell people.

Glutathione is one of the primary antioxidants that we need to help clear xenobiotics, free radicals, reactive oxygen species, sugar, excess fats/protein, etc, etc, and when low, liver detoxification will be impaired.

Producing & recycling of glutathione requires a number of genes and enzymes that hypothyroidism may negatively influence. Transdermal application has been shown to be successful, although the most effective way of supplementing glutathione is liposomal away from foods but it is very expensive.

I have an absence of the glutathione gene and am advised to supplement as have high risk of oxidative damage due to haemochromatosis. I supplement for a while and then sometimes switch to NAC which is the precursor to glutathione and much cheaper.

[arTistapple in reply to radd]

I guess these guys - even the good guys - have to make their money somehow but the message does get lost in the apparent ‘get rich quick schemes’ they get involved in. Over the years I have been involved with quite a number of these types of things and practitioners. Macrobiotics. Raw food. Alkaline. Paleo. Many books with many theories. Probably many more I have forgotten about. Anyway I have found all sorts of unbalancing issues in them all - apparently debunked in new theories when ultimately thyroid issues seem to be at the bottom of it all - maybe. It’s all very difficult to keep up with. I just saw the bit about the glutathione cream and as I am filling myself with umpteen vitamins and minerals I thought it might have been easy and useful to do. I am very interested in you saying you have haemochromatosis, which I gather is the opposite of many thyroid sufferers (them having low ferritin). I am getting tested for that myself, if my levels don’t go down by mid September. I did not know about a glutathione gene. I am seriously considering the gene test for T4/T3 conversion. I would like to know this just in case I can use it to get NHS T3. However you have intrigued me about the glutathione gene. Can you tell me where you got the testing done? Just wondering if it’s worth trying to get both done at the same time. I know a bit about NAC but have not seen glutathione anywhere and I was under the impression that it was not easily absorbed by mouth, hence the other reference to through the skin - perhaps my copy of Datis Kharrazian’s is indeed out of date. Not sure thyroid wise if there is a point, as I have had the disease so long there is nothing there to resurrect but there may be other reasons I should look at it again. Anyway thanks for getting back to me on this subject, much appreciated.

[radd in reply to arTistapple]

arTistapple,

Yes, you are right. Oral forms weren’t very successful but the latest form is S-acetyl L-glutathione in a liposomal solution that is supposed to be much better absorbed. Supposedly the biggest glutathione depleter is heavy metal/toxic overload. I had my mouthful of amalgam removed several years ago and chelated for 6 months.

Another member was asking about the Blue Horizon genetic thyroid testing this morning and how useful it would be. I think very useful.

[arTistapple in reply to radd]

Thanks for getting back to me. My book is clearly out of date right enough. I will look again at the glutathione thing. However my thyroid is most likely dead or on its last legs! And I have no sign of any other auto-immune so I will most likely work with what I have got.

[bookish in reply to HowNowWhatNow]

I'm afraid my opinion of Google for health is such that Datis Kharrazian being called a quack would make me want to read him more rather than less! I have both books - thyroid and brain - and have found them interesting and helpful. I've watched some of his stuff too and he is so quick you really have to concentrate. Medical doctor? No idea, but he was a research fellow and post-doctorate at Harvard plus his Masters so probably not a complete idiot. Like radd I have a glutathione absent gene and in conjunction with other SNPs that increases risk for a few things. I use NAC along with a glutathione and alpha ketoglutaric acid -containing supplement and milk thistle/vit C/sulphur foods. (Glutathione useful re. covid too, it seems ncbi.nlm.nih.gov/pmc/articl... Cheers

[radd in reply to bookish]

Oh bookish, you have the absent glutathione gene too!

🤔 I wonder how many others? It's not something routinely tested so I guess we might never know. I'm not familiar with alpha ketoglutaric acid although have read about the Krebs cycle.

[bookish in reply to radd]

Hi! Yes, I've wondered the same. When I asked Micki Rose about how significant it might be, she said we have other pathways and more than one gene, so one absence (which I have) of the two tested wasn't insurmountable. But with reading recently that sarcopenia is linked to higher oxidative stress and low glutathione, and that poor covid outcomes could also be connected (frontiersin.org/articles/10... I'm happier to know about it and be trying to give it a bit of a boost. The ketoglutaric is in my Kirkman's detox supplement - their website says it is better tolerated by some than NAC. I haven't noticed a problem with NAC but only take half a tablet daily (except for when I had covid!!). Also a possibly significant connection between glutathione null/poor and COMT and breast cancer (and I have slow COMT) ncbi.nlm.nih.gov/pmc/articl.... Hope you are doing ok. Best wishes