Does omeprazole reduce thyroid drug absorption?

[Girlslovescifi]

I’ve been put on omeprazole and have been experiencing real crashes where I get so sleepy mid morning and mid afternoon. I take it 4 hours away from my thyroid meds. Anyone else experience this?

[greygoose]

Probably. And would reduce absorption of nutrients, too - like iron, which would make you tired. You probably had low stomach acid, anyway, even before you started taking it.

[Girlslovescifi in reply to greygoose]

I’ve only been on them 5 days but before that I was on a course of antibiotics for sinusitis and I’m not sure they help absorption. And how do you convince doctors that low stomach acid when you’re hypo is a real thing? 🙄

[greygoose in reply to Girlslovescifi]

Ask them to test it. This article is about testing stomach acid levels:

healthygut.com/3-tests-for-...

[Girlslovescifi in reply to greygoose]

Thank you!!

[greygoose in reply to Girlslovescifi]

You're welcome.

[A2C3]

Hey I found it really affected my absorption of thyroid medication - helpful article here it reduces absorption for the full day - drugs.com/medical-answers/a...

[Girlslovescifi in reply to A2C3]

That would explain a lot! Thank you!

[A2C3 in reply to Girlslovescifi]

Same thing happened to me after sinusitis (although it’s now chronic and I’m on different medication) I was given doxycycline and it gave me gastritis so then had to have omeprazole, took me 6 months to get off it! I hate it!

[Girlslovescifi in reply to A2C3]

Sorry to hear that!

[helvella Administrator Thyroid UK]

It is well-known to affect absorption of vitamin B12.

[Girlslovescifi in reply to helvella]

Thank you. I’ve stopped it and told my doctor why.

[Nanny23 in reply to Girlslovescifi]

I had same problem with that medication. I now take Pepsid and it seems ok.

[Girlslovescifi in reply to Nanny23]

Thanks. That’s good to know.

[SlowDragon Administrator]

Check your vitamin levels after antibiotics

Vitamin D, folate, ferritin and B12

Consider a probiotic and/or fermented foods like kefir, sauerkraut etc

When hypothyroid we frequently have low vitamin levels

Omeprazole will lower vitamin levels even further

gov.uk/drug-safety-update/p...

webmd.com/heartburn-gerd/ne...

pharmacytimes.com/publicati...

PPI and increased risk T2 diabetes

gut.bmj.com/content/early/2...

Iron Deficiency and PPI

medpagetoday.com/resource-c...

futurity.org/anemia-proton-...

onlinelibrary.wiley.com/doi...

sciencedirect.com/science/a...

[Girlslovescifi in reply to SlowDragon]

Thanks. I took a probiotic specifically for antibiotics, as apparently the strains survive. I also take a good B complex, bone complex, Selenium, etc. I also love sauerkraut!