Am I undermedicated? What should my next steps be? - Thyroid UK

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Am I undermedicated? What should my next steps be?

Kook22 profile image
14 Replies

I am currently on 125mg of Levothyroxine.

Results from 5th July:

TSH 1.2 (normal range 0.27 - 4.2 mU/L)

FT4 15.2 (normal range 12 - 22 pmol/L)

FT3 4.6 (normal range 3.1 - 6.8 pmol/L)

so all normal range

Other blood results

My serum ferritin is high 191g/l (normal range 6-81) since at least October 2021, the first time it was tested.

Serum alkaline phosphatase low since 2015. Test not repeated since Nov 2021.

Serum triglycerides, Serum ALT level high since 2019. Tests not repeated since Nov 2021.

I have high cholesterol and has been increasing since 2016.

I am a coeliac.

I’ve had the bloods taken at the GP 4 times since October, Serum Ferritin high each time. GP said to keep repeating the test but has not got in touch since last result on 19 May.

I saw a private consultant in November who advised to get my TSH below 1, which it was back in May, but it’s now increased to 1.2.

However I don’t feel 100% even when TSH was below 1, but I don’t know what my next steps would be. Can anyone offer some advice?

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Kook22
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14 Replies
SeasideSusie profile image
SeasideSusieRemembering

Kook22

Please add reference ranges for your thyroid tests, ranges vary from lab to lab so we can't tell you if you are undermedicated until we see the ranges that came with your results.

SlowDragon profile image
SlowDragonAdministrator

How old are you approx….pre or post menopause

What vitamin supplements are you currently taking

When were vitamin D, folate, B12 levels last tested

How long since you were diagnosed as coeliac

Which brand of levothyroxine are you currently taking

Do you always get same brand levothyroxine at each prescription

Was this test done early morning, ideally before 9am and last dose levothyroxine 24 hours before test

Kook22 profile image
Kook22 in reply to SlowDragon

thanks for your replies, I've updated the post with the ranges.

I'm 42, pre menopause. I take 100ug of Vitamin D, each day, Folate not so regularly.

B12: 532 (normal range 223 - 1132) Tested Feb 22

Vitamin D: 52 (normal range 50-125) Tested Feb 22 After this I started taking the 100ug of Vitamin D but not had it retested.

Serum folate: 7.5ug/L (normal range 3.9 - 20.0) Tested Feb 22 though previously in Nov 21 it was 3.5 ug/L

I've been a coeliac for 9 years and I'm very strict with it as I cannot tolerate any gluten.

25mg Brand of Levothyroxine is wockhardt

100 mg Brand of Levothyroxine is aristo

I fairly certain the pharmacist changes the brand regularly, perhaps Teva brand on occasions.

The test yesterday was done before 9am and last dose of levothyroxine was over 24 hours before test.

SlowDragon profile image
SlowDragonAdministrator in reply to Kook22

Request small increase in levothyroxine

Perhaps 12.5mcg (half a 25mcg tablet) per day

Retest thyroid levels 6-8 weeks after dose increase

Things to try/consider

Work out which brand levothyroxine suits you best and always get same brand at each prescription

Many patients do NOT get on well with Teva brand of Levothyroxine.

But for some people (usually if lactose intolerant, Teva is by far the best option)

Teva, Glenmark or Aristo (100mcg only) are the only lactose free tablets

Most easily available (and often most easily tolerated) are Mercury Pharma or Accord

Mercury Pharma make 25mcg, 50mcg and 100mcg tablets

Accord only make 50mcg and 100mcg tablets

Accord is also boxed as Almus via Boots, and Northstar 50mcg and 100mcg via Lloyds ....but Accord doesn’t make 25mcg tablets

beware 25mcg Northstar is Teva

Wockhardt only make 25mcg tablets

List of different brands available in U.K.

thyroiduk.org/if-you-are-hy...

Once you find a brand that suits you, best to make sure to only get that one at each prescription.

New guidelines for GP if you find it difficult/impossible to change brands

gov.uk/drug-safety-update/l...

If a patient reports persistent symptoms when switching between different levothyroxine tablet formulations, consider consistently prescribing a specific product known to be well tolerated by the patient. If symptoms or poor control of thyroid function persist (despite adhering to a specific product), consider prescribing levothyroxine in an oral solution formulation.

academic.oup.com/jcem/artic...

Physicians should: 1) alert patients that preparations may be switched at the pharmacy; 2) encourage patients to ask to remain on the same preparation at every pharmacy refill; and 3) make sure patients understand the need to have their TSH retested and the potential for dosing readjusted every time their LT4 preparation is switched (18).

Vitamin D obviously needs retesting

I take 100ug of Vitamin D, each day,

Do you mean 1000iu vitamin D?

Might not be high enough dose

Do you supplement magnesium?

Folate not brilliant

A daily good quality vitamin B complex with folate in (not folic acid)

This can help keep all B vitamins in balance and will help improve B12 levels too

Difference between folate and folic acid

chriskresser.com/folate-vs-...

Many Hashimoto’s patients have MTHFR gene variation and can have trouble processing folic acid.

thyroidpharmacist.com/artic...

B vitamins best taken after breakfast

Thorne Basic B or Jarrow B Right are recommended options that contains folate, but both are large capsules. (You can tip powder out if can’t swallow capsule)

IMPORTANT......If you are taking vitamin B complex, or any supplements containing biotin, remember to stop these 7 days before ALL BLOOD TESTS , as biotin can falsely affect test results

endo.confex.com/endo/2016en...

endocrinenews.endocrine.org...

In week before blood test, when you stop vitamin B complex, you might want to consider taking a separate methyl folate supplement

Kook22 profile image
Kook22 in reply to SlowDragon

Thank you for taking the time to get back to me. This is very useful I just need take some time to digest.

SlowDragon profile image
SlowDragonAdministrator

Assuming test done as advised

FT4: 15.2 pmol/l (Range 12 - 22)

Ft4 is only 32.00% through range

FT3: 4.6 pmol/l (Range 3.1 - 6.8)

Ft3 40.54%

So likely to need dose increase in levothyroxine, but results currently suggest good conversion

humanbean profile image
humanbean

My serum ferritin is high 191g/l (normal range 6-81)

That is a very strange reference range for ferritin. Could you check it please.

Serum alkaline phosphatase low since 2015.

This might be helpful:

labs.selfdecode.com/blog/lo...

Serum triglycerides, Serum ALT level high since 2019

High triglycerides and ALT are both usually caused by a diet which is high is sugar and carbs. I'm sure there must be other causes too.

labs.selfdecode.com/blog/hi...

labs.selfdecode.com/blog/tr...

labs.selfdecode.com/blog/lo...

Kook22 profile image
Kook22 in reply to humanbean

Thanks for the reply. I've just checked the Serum ferritin and it shows normal range 6 - 81ug/L, possibly a typo above as I put g/l. Those links are useful, and I should look at my diet.

humanbean profile image
humanbean in reply to Kook22

I've never seen a range of 6 - 81 with any units of measurement. A common range for ferritin for females in the UK is around 13 - 150. Other ranges I've seen are 13 - 400. Some people have quoted ranges with a top of range of 220 or 300. But a top of range of under 100 would be a first. I'm sure that somewhere there must have been a mistake, but I don't know where.

Kook22 profile image
Kook22 in reply to humanbean

This was a test from the GP, but you are right googling it, it does seem an odd normal range.

Serrum ferritin graph
helvella profile image
helvellaAdministratorThyroid UK in reply to Kook22

Can you let us know which lab it was?

(Please don't feel pushed to answer if you don't want to reveal your approximate location in public.)

I'd like to check what the lab's website says - some new testing technique or machine?

Kook22 profile image
Kook22 in reply to helvella

It was a GP test, so I think it was sent to Wirral University Teaching Hospital's pathology lab.

helvella profile image
helvellaAdministratorThyroid UK in reply to Kook22

Hmm. Interesting and thanks. But confusing!

That lab's pathology handbook (link below) has these ranges:

Ferritin Serum

Male Adult 30 – 400 µg/L

Female Adult 13 – 150 µg/L

wuth.nhs.uk/media/20660/cli...

helvella profile image
helvellaAdministratorThyroid UK in reply to Kook22

I strongly urge you to ring the lab.

If it is the wrong lab, they'll surely know what labs it could have been. And if the numbers are getting scrambled between them and the GP, that is a vitally important issue which could have life-threatening implications (if it is more widespread than just your ferritin test/reference interval).

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