I changed from Accord to Aristo and this morning felt full on overload like I’d raised a dose. Could a brand change have such a big effect? I also took Clonazapam at 4 am because I couldn’t sleep so thyroid meds and those meds are not a good combination either.
Mainly wondering about the brand change
Many thanks
Some would say it's not possible to feel much different on morning of day 1 with Levothyroxine , but i can tell subtle differences in how i feel on a new brand after just a day or two. I think it's more likely to be the other thing you took /lack of sleep/ etc .rather than a sign that the Aristo doesn't suit you , or is working faster or whatever .
Even when a different brand makes me feel a bit weird/different for a few days . i usually find that over the next week or two ,i stop noticing anything and feel OK again . (apart from Teva... on that i continue to feel too slow and a bit rubbish ... so i don't have Teva anymore )
Give it a week or two and then see how you feel ?
Thanks so much for your reply. It makes me think that the Accord was not that effective because yesterday I had a heightened anxiety feeling as well and that was the first day I took the different brand. Also when you take 125 because 25 only comes as Wockhardt so a different brand again! I’llsoon get my blood test results so
I’ll see.
I think it could be more the combination of Valium type meds with thyroxine not good.
Many people find Levothyroxine brands are not interchangeable.
Teva, or Aristo (100mcg only) are the only lactose free tablets
Most easily available (and often most easily tolerated) are Mercury Pharma or Accord
Mercury Pharma make 25mcg, 50mcg and 100mcg tablets
Accord only make 50mcg and 100mcg tablets
Accord is also boxed as Almus via Boots, and Northstar 50mcg and 100mcg via Lloyds ....but Accord doesn’t make 25mcg tablets
beware 25mcg Northstar is Teva
Many patients do NOT get on well with Teva brand of Levothyroxine.
Teva contains mannitol as a filler, which seems to be possible cause of problems. Teva is the only brand that makes 75mcg tablet. So if avoiding Teva for 75mcg dose ask for 25mcg to add to 50mcg or just extra 50mcg tablets to cut in half
But for some people (usually if lactose intolerant, Teva is by far the best option)
List of different brands available in U.K.
thyroiduk.org/if-you-are-hy...
Posts that mention Teva
healthunlocked.com/search/p...
Teva poll
healthunlocked.com/thyroidu...
Once you find a brand that suits you, best to make sure to only get that one at each prescription.
Which brand of levothyroxine do you normally prefer
Watch out for brand change when dose is increased or at repeat prescription.
New guidelines for GP if you find it difficult/impossible to change brands
gov.uk/drug-safety-update/l...
If a patient reports persistent symptoms when switching between different levothyroxine tablet formulations, consider consistently prescribing a specific product known to be well tolerated by the patient. If symptoms or poor control of thyroid function persist (despite adhering to a specific product), consider prescribing levothyroxine in an oral solution formulation.
academic.oup.com/jcem/artic...
Physicians should: 1) alert patients that preparations may be switched at the pharmacy; 2) encourage patients to ask to remain on the same preparation at every pharmacy refill; and 3) make sure patients understand the need to have their TSH retested and the potential for dosing readjusted every time their LT4 preparation is switched (18).
Levothyroxine is an extremely fussy hormone and should always be taken on an empty stomach and then nothing apart from water for at least an hour after
Many people take Levothyroxine soon after waking, but it may be more convenient and perhaps more effective taken at bedtime
verywellhealth.com/best-tim...
No other medication or supplements at same as Levothyroxine, leave at least 2 hour gap.
Some like iron, calcium, magnesium, HRT, omeprazole or vitamin D should be four hours away
(Time gap doesn't apply to Vitamin D mouth spray)
If you normally take levothyroxine at bedtime/in night ...adjust timings as follows prior to blood test
If testing Monday morning, delay Saturday evening dose levothyroxine until Sunday morning. Delay Sunday evening dose levothyroxine until after blood test on Monday morning. Take Monday evening dose levothyroxine as per normal
Chang of brand in carbimazole
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Brand change of levothyroxine 
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Change in Brand of levothyroxine
