Testing for Dio 1 and Dio 2

[Poonam1]

I hope everyone is in good health,

Please can I ask if anyone can private message me with details on how to find a clinic that may do the Dio 1/2 testing? Really appreciated.

Thanks

P😊

[helvella Administrator]

There is no need for replies to be by private message.

[Jazzw]

You might find this article helpful. (Links to places which do the test at the end).

paulrobinsonthyroid.com/dio...

[Anthea55]

See this previous post and following replies. Various alternatives healthunlocked.com/thyroidu...

[Anthea55 in reply to Anthea55]

By the way, it's so easy to get confused with numerals and letters - I know I did until recently. Correct is DIO(letters) and 2(number), but when I googled for DI(letters) and 02(numbers) it said it included results for DIO2.

[helvella Administrator in reply to Anthea55]

Thank you for that!

I have posted as below numerous times and it is great to see someone else point it out! It is only intended to be helpful - not critical of the poster(s).

For clarity, the gene that affects T4 to T3 conversion is called DIO2 - that is, three letters and a number. Not D102 - a letter and three numbers. Not DI02 - two letters and two numbers.

The name comes from the enzyme that this gene affects which is a deiodinase. It removes an iodine atom from a thyroid hormone molecule - it deiodinates it.

On this forum we probably understand, but if you wish to look it up anywhere, it might help to get it right. If you are discussing with a doctor, and get it wrong, you are providing an excuse for them to dismiss what you say.

(More strictly, two single-nucleotide polymorphisms (SNPs) on the DIO2 gene, rs225014 and rs225015.)

academic.oup.com/jcem/artic...

The Wiki article provides a basic introduction as to what a single-nucleotide polymorphism (SNP) is and why it can be important:

en.wikipedia.org/wiki/Singl...

[DippyDame in reply to Anthea55]

Or even less confusing Dio2,

That form avoids confusion of DIO2 as D- one hundred and two!

Given that O can be confused with 0!

The number on the door of 10 Downing Street reads 1O

Sorry, just being a pain!!

Edit

PS You really don't want to know this I'm guessing but...

Curiosity got the better of me. I know, it killed the cat!!!

typefoundry.blogspot.com/20...

This paper re Dio2 may be of interest Poonam1

academic.oup.com/jcem/artic...

[Anthea55 in reply to DippyDame]

From the days when I wrote programs in pencil on coding sheets which were then punched into cards and verified before being fed into the computer, you had to be careful to distinguish various letters. O or O with a / through it (but offhand I don't remember which was the zero). Also confusing, 1 or L, probably others.

[SlowDragon Administrator]

Regenerus are currently not able to do DIO2 gene test until Nov

thyroiduk.org/help-and-supp...