Meta-analysis link for low/suppressed TSH please

[DGHT]

Hi

I am currently on T3 45mcg daily. My most recent bloods show a TSH of 0.01 and FT3 of 4.9 taken fasting with a split dose 10 hours before at 9am. I do not have the ranges as you have to fill in a form every time to request your blood results and then the GP makes you wait the entire 30 days for a copy. I live in Northern Ireland. I do not have the ranges and would need to wait another 30 days for them.

All of a sudden I have an Endocrinologist appt on Monday so I am assuming the GP freaked about the low TSH and contacted him. Perish the thought of having an actual conversation with the patient who understands her thyroid blood results better than her.

I am looking for the link to the meta-analysis that demonstrates a low/suppressed test does cause AF/osteoporosis etc please. I think it was Scottish University/lecturer. Would just like to be prepared for an push of a T3 reduction from Endo.

Many thanks

[endomad]

I used Paul Robinsons T3 info for my endo, lots of useful stuff on there:paulrobinsonthyroid.com/can...

I dont have link for Scottish Dr Skinner also google Dr Lowe who was on T3 himself.

[DGHT in reply to endomad]

Thanks for this. My Endocrinologist isn't the worst but I just need to be prepared in case. I saw an Registrar one time as there was a mix up, so going without being forearmed could detrimentally impact me health for months.

[SeasideSusie Remembering]

DGHT

This article about Myths of Hypothyroidism is on ThyroidUK's website and one of them is about the myth that a suppressed TSH leads to Osteoporosis

thyroiduk.org/further-readi...

You might find these previous posts on the forum helpful

healthunlocked.com/thyroidu...

healthunlocked.com/thyroidu...

healthunlocked.com/thyroidu...

healthunlocked.com/thyroidu...

healthunlocked.com/thyroidu...

Also, Dr Toft, past president of the British Thyroid Association and leading endocrinologist, states in Pulse Magazine (the professional publication for doctors):

"The appropriate dose of levothyroxine is that which restores euthyroidism and serum TSH to the lower part of the reference range - 0.2-0.5mU/l. In this case, free thyroxine is likely to be in the upper part of its reference range or even slightly elevated – 18-22pmol/l. Most patients will feel well in that circumstance. But some need a higher dose of levothyroxine to suppress serum TSH and then the serum-free T4 concentration will be elevated at around 24-28pmol/l. This 'exogenous subclinical hyperthyroidism' is not dangerous as long as serum T3 is unequivocally normal – that is, serum total around T3 1.7nmol/l (reference range 1.0-2.2nmol/l).*"

He's unlikely to say that if there is evidence it will cause osteoporisis (or AF).

[DGHT in reply to SeasideSusie]

Thank you so much. I will get a good read and gather the information I need.

[asiatic]

I use the following paper that says low TSH ( down to 0.04 ) is safe.

Serum thyroid-stimulating hormone concentration and morbidity from cardiovascular disease and fractures in patients on long-term thyroxine therapy

Robert W. Flynn, Sandra R. Bonellie, Roland T. Jung, Thomas M. MacDonald, Andrew D. Morris, Graham P. Leese

[DGHT in reply to asiatic]

This is the exact one I meant! I will file it properly on my phone this time. Thank you so much.

[shaws in reply to DGHT]

It's unfortunate that our UK experts are not so 'expert'.

[Heloise]

This was an interesting list of research articles I found on a Canadian thyroid website. thyroidpatients.ca/campaign...

There are about 200, Paul Robinson is listed at 196 and 197

So many topics covered, you would think we would know how to treat more effectively.