Straining at a camel and producing a gnat

FYI at TUK there has been recently in Clinical Thyroidal journal a meta- analysis paper on the risk of bone fractures in subclinical hyperthyroidism i.e. TSH's < 0.1 unit with normal FT4. No FT3 mentioned or done. I quote from the paper what I think is the culminating but less than impressive outcome:

Although the HRs for subclinical hyperthyroidism and all outcomes are significantly positive, the absolute excess number of fractures is still relatively small (i.e., 1 excess hip fracture for every 1000 person-years).

OK there is an increased risk but how small! Would you take the risk? I think I know the answer.

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4 Replies

  • Diogenes, Hardly warrants the dire warnings about low and suppressed TSH causing osteoporosis does it? That very small increased risk is acceptable to me.

  • Is there a link available to the meta analysis?

    I found this :

    but am not sure if it is the paper being referred to. The link I've given is to a whole paper rather than just an abstract.

  • This is the paper quoted:

    Leung Angela M.. Clinical Thyroidology. July 2015, 27(7): 174-176. doi:10.1089/ct.2015;27.174-176.

  • Thank you. :)

    This is the title and a link to the abstract :

    "Subclinical Hyperthyroidism Is Associated with Increased Risks of Hip Fractures, Fractures at Any Site, Nonspine Fractures, and Clinical Spine Fractures in the Largest Meta-analysis to Date"

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