TSH is a growth factor for melanoma : doi.org/1... - Thyroid UK
TSH is a growth factor for melanoma
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Tyrosine has a big role in messaging to make thyroid hormone tyrosine also creates melanin which helps us tan, those tanning tablets you can buy to help you tan are made from tyrosine
Years ago, if I remember correctly, Patients that had thyroid cancer and thyroid removed needed to have their TSH totally suppressed, something like less than .01. Not sure if this is the current protocol today.
Also, some alternative doctors, If i remember correctly, would also totally suppress TSH on hashi's patients many years ago.
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A more recent paper explores further (and cites this paper)
The Molecular Function and Clinical Role of Thyroid Stimulating Hormone Receptor in Cancer Cells
by Yu-De Chu
1 and Chau-Ting Yeh
Cells 2020, 9(7), 1730; doi.org/10.3390/cells9071730
Thank you for posting Gigi216. my TSH has been riding high and my GP was happy to let that happen indefinitely. I had to persistently ask (3 times), to be referred to an endocrinologist. Potentially Reports like this can be used by patients to insist on action to get TSH down.
I wonder if sticking this under GP’s noses that they’ll think twice about still making people wait until they have two TSH results over 10. It would be good but I doubt it.
Well it would be wonderful to get those old guides about TSH changed, I’m so glad y’all are seeing this to advocate for yourselves and avoid getting cancer like I did!
Trouble is, the "old guides" include the latest NICE guidance.
Thyroid disease: assessment and management
NICE guideline [NG145] Published: 20 November 2019
Well what is usual course that is taken to change guidance? Do y’all petition? Unfortunately I think individuals may have to advocate for themselves showing these studies to physicians until it can be changed, that’s why as many as possible need this information
This was near the very end of the article. I put it here in case people missed it: "Patients with TSH levels in the upper normal range should begin exogenous thyroid hormone replacement to suppress circulating TSH concentrations, and overt hypothyroidism should be managed aggressively to avoid intermittent TSH elevations." Wow!
Yes! This information can save lives, I’m lucky my melanoma didn’t progress. Just think of the people who have cancer and NEED this information
I mean if you have melanoma currently can taking thyroid hormone help you overcome it? People in that position need to know
I think it very much depends on whether the elevated TSH is a contributor to melanoma, or whether melanoma should be regarded as a nonthyroidal illness which incidentally raises TSH. Either possibilityis stillon the cards . Also, different forms of TSH have different functions and it may be a specific type of TSH is having an effect, independently of the thyroid-stimulating version..
Well I’m not certain, from everything I’ve read so far it seems elevated TSH stimulates melanoma growth not melanoma affects TSH. I’ll continue to research that though! I’ve really enjoyed your posts over the years, thank you so much for sharing your knowledge
Here is a grant to study melanoma and it mentions that TSH is what stimulates melanoma