TSH is a growth factor for melanoma : doi.org/1... - Thyroid UK

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TSH is a growth factor for melanoma

Gigi216 profile image
22 Replies

doi.org/10.1677/erc.1.01239

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Gigi216 profile image
Gigi216
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22 Replies
Lizzo30 profile image
Lizzo30

Tyrosine has a big role in messaging to make thyroid hormone tyrosine also creates melanin which helps us tan, those tanning tablets you can buy to help you tan are made from tyrosine

veryland profile image
veryland

Years ago, if I remember correctly, Patients that had thyroid cancer and thyroid removed needed to have their TSH totally suppressed, something like less than .01. Not sure if this is the current protocol today.

Also, some alternative doctors, If i remember correctly, would also totally suppress TSH on hashi's patients many years ago.

Gigi216 profile image
Gigi216 in reply to veryland

Yes I think you are correct. I was diagnosed with malignant melanoma in 2001 with a TSH of 5 so an elevated TSH can influence many things in the body

Gingernut44 profile image
Gingernut44

That’s very interesting, thanks for posting

Gigi216 profile image
Gigi216 in reply to Gingernut44

Very welcome!

helvella profile image
helvellaAdministratorThyroid UK

A more recent paper explores further (and cites this paper)

The Molecular Function and Clinical Role of Thyroid Stimulating Hormone Receptor in Cancer Cells

by Yu-De Chu

1 and Chau-Ting Yeh

Cells 2020, 9(7), 1730; doi.org/10.3390/cells9071730

mdpi.com/2073-4409/9/7/1730...

Gigi216 profile image
Gigi216 in reply to helvella

Wonderful finds helvella! Thank you

ShatteredofLee profile image
ShatteredofLee

Thank you for posting Gigi216. my TSH has been riding high and my GP was happy to let that happen indefinitely. I had to persistently ask (3 times), to be referred to an endocrinologist. Potentially Reports like this can be used by patients to insist on action to get TSH down.

Gigi216 profile image
Gigi216 in reply to ShatteredofLee

Wonderful! Yes don’t let it stay high mine was a 5 when I developed malignant melanoma

Gingernut44 profile image
Gingernut44

I wonder if sticking this under GP’s noses that they’ll think twice about still making people wait until they have two TSH results over 10. It would be good but I doubt it.

Gigi216 profile image
Gigi216 in reply to Gingernut44

Well it would be wonderful to get those old guides about TSH changed, I’m so glad y’all are seeing this to advocate for yourselves and avoid getting cancer like I did!

helvella profile image
helvellaAdministratorThyroid UK in reply to Gigi216

Trouble is, the "old guides" include the latest NICE guidance.

Thyroid disease: assessment and management

NICE guideline [NG145] Published: 20 November 2019

nice.org.uk/guidance/ng145

Gigi216 profile image
Gigi216 in reply to helvella

Well what is usual course that is taken to change guidance? Do y’all petition? Unfortunately I think individuals may have to advocate for themselves showing these studies to physicians until it can be changed, that’s why as many as possible need this information

helvella profile image
helvellaAdministratorThyroid UK in reply to Gigi216

I think you'll have to search round the NICE site to find out. I keep meaning to find out but haven't yet done so!

Ukie profile image
Ukie

This was near the very end of the article. I put it here in case people missed it: "Patients with TSH levels in the upper normal range should begin exogenous thyroid hormone replacement to suppress circulating TSH concentrations, and overt hypothyroidism should be managed aggressively to avoid intermittent TSH elevations." Wow!

Gigi216 profile image
Gigi216 in reply to Ukie

Yes! This information can save lives, I’m lucky my melanoma didn’t progress. Just think of the people who have cancer and NEED this information

Gigi216 profile image
Gigi216 in reply to Ukie

I mean if you have melanoma currently can taking thyroid hormone help you overcome it? People in that position need to know

diogenes profile image
diogenesRemembering in reply to Gigi216

I think it very much depends on whether the elevated TSH is a contributor to melanoma, or whether melanoma should be regarded as a nonthyroidal illness which incidentally raises TSH. Either possibilityis stillon the cards . Also, different forms of TSH have different functions and it may be a specific type of TSH is having an effect, independently of the thyroid-stimulating version..

Gigi216 profile image
Gigi216 in reply to diogenes

Well I’m not certain, from everything I’ve read so far it seems elevated TSH stimulates melanoma growth not melanoma affects TSH. I’ll continue to research that though! I’ve really enjoyed your posts over the years, thank you so much for sharing your knowledge

Gigi216 profile image
Gigi216 in reply to Gigi216

Here is a grant to study melanoma and it mentions that TSH is what stimulates melanoma

grantome.com/grant/NIH/R21-...

Gigi216 profile image
Gigi216 in reply to diogenes

Here’s more on subject

grantome.com/grant/NIH/R21-...

Gigi216 profile image
Gigi216 in reply to Ukie

Also in the articles helvella posted it talks about TSH receptors in ovarian and hepatic cancers! People who have those cancers need to be aware of lowering their TSH helping them keep those cancers in remission!

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