TPO Antibodies: Hi I am new to this and wondering... - Thyroid UK

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TPO Antibodies

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Hi I am new to this and wondering if anyone could shed any light. I've just had an autoimmune test and come back that I have TPO antibodies that are level 10.6. I also suffer with low haemoglobin levels, really bad leg aches etc

Haematocrit 0.369

Mean cell haemoglobin level 25.1 pg

Mean cell haemoglobin concentration 309.0 g/L

Any advice is really appreciated

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SeasideSusie profile image
SeasideSusieRemembering

DMsentance

To be able to interpret your results and help you, can you please provide the reference ranges that come with your results. Ranges vary from lab to lab, for example TPO antibody range can be 0-34, 0-50 or 0-60 and that's just some of the ranges we see here.

DMsentance profile image
DMsentance in reply to SeasideSusie

IThyroid function testSerum TSH level 1.46 mu/L [0.35 - 4.94]

Serum free T4 level 13.5 pmol/L [9.0 - 19.0

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DMsentance

Sorry ...

TPO is range between 0 -35

Haematocrit 0.369 [0.37 - 0.47]

Mean cell haemoglobin level 25.1 pg [27.0 - 32.0

Mean cell haemoglobin concentration 309.0 g/L [310.0 - 350.0]

Thanks

SeasideSusie profile image
SeasideSusieRemembering in reply to DMsentance

DMsentance

Your TPO negatives are within range therefore they are negative for autoimmune thyroid disease as far as that test is concerned. However, we can have negative TPO antibodies but positive Thyroglobulin antibodies so it would wise to have those checked. Also, we can have negative antibodies but still have Hashimoto's.

All your other results are below range and should be discussed with your GP, they may possibly indicate anaemia (I am not diagnosing, I am not medically qualified). Do you have any other results - haemoglobin, iron panel, B12, folate?

DMsentance profile image
DMsentance in reply to SeasideSusie

Serum vitamin B12 levelSerum vitamin B12 level 253 ng/L [187.0 - 883.0]

Serum folate level

Serum folate level 3.9 ug/L [3.1 - 20.5]

Serum ferritin level

Serum ferritin level 12 ug/L [10.0 - 204.0]

Please see above. These were a few months ago x

SeasideSusie profile image
SeasideSusieRemembering in reply to DMsentance

DMsentance

Results a few months old aren't really relevant how but if you had posted them at the time these would have been my comments (in italics):

Serum vitamin B12 level 253 ng/L [187.0 - 883.0]

This is low, many people with a B12 level in the 300s have been found to need B12 injections. Do you have any signs of B12 deficiency – check here:

b12deficiency.info/signs-an...

b12d.org/submit/document?id=46

If you do then list them to discuss with your GP and ask for testing for B12 deficiency and Pernicious Anaemia. Do not take any B12 supplements or folic acid/folate/B Complex supplements before further testing of B12 as this will mask signs of B12 deficiency and skew results.

So it might be worth repeating your B12 test.

Serum folate level 3.9 ug/L [3.1 - 20.5]

Extremely low, just in range, possibly suggestive of folate deficiency - see

cks.nice.org.uk/anaemia-b12...

Folate level

◦Serum folate of less than 7 nanomol/L (3 micrograms/L) is used as a guide to indicate folate deficiency.

◦However, there is an indeterminate zone with folate levels of 7–10 nanomol/L (3–4.5 micrograms/L), so low folate should be interpreted as suggestive of deficiency and not diagnostic.

I would ask for folate to also be retested.

Serum ferritin level 12 ug/L [10.0 - 204.0]

Absolutely dire. Possibly suggestive of iron deficiency anaemia. An iron panel needs to be done.

Definitely repeat ferritin test now unless you have had iron supplements and are being monitored regularly.

Please see above.

After interpreting your TPO result I mentioned above in reply to your test results posted in your opening post:

"All your other results are below range and should be discussed with your GP, they may possibly indicate anaemia"

DMsentance profile image
DMsentance

There is a heavy auto immune family history aswel.

SeasideSusie profile image
SeasideSusieRemembering in reply to DMsentance

DMsentance

There is a heavy auto immune family history aswel.

And it's possible that you do have Hashi's as I said

However, we can have negative TPO antibodies but positive Thyroglobulin antibodies so it would wise to have those checked. Also, we can have negative antibodies but still have Hashimoto's.

and that could be the reason for your dire nutrient levels, but you need up to date results, you can't rely on old results.

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