This paper shows the effect of vitamin D on the level of antibodies in Hashimoto's thyroiditis. Vitamin D is shown to significantly reduce antibody load.
Horm Metab Res 2019; 51(05): 296-301
DOI: 10.1055/a-0856-1044
Endocrine Care
Can Supplementation with Vitamin D Modify Thyroid Autoantibodies (Anti-TPO Ab, Anti-Tg Ab) and Thyroid Profile (T3, T4, TSH) in Hashimoto’s Thyroiditis? A Double Blind, Randomized Clinical Trial
Vitamin D deficiency is frequent in Hashimoto's thyroiditis and treatment of patients with this condition with Vitamin D may slow down the course of development of hypothyroidism and also decrease cardiovascular risks in these patients. Vitamin D measurement and replacement may be critical in these patients.
Vitamin D insufficiency was associated with AITD and HT, especially overt hypothyroidism. Low serum vitamin D levels were independently associated with high serum TSH levels.
The thyroid hormone status would play a role in the maintenance of vitamin D sufficiency, and its immunomodulatory role would influence the presence of autoimmune thyroid disease. The positive correlation between free T4 and vitamin D concentrations suggests that adequate levothyroxine replacement in HT would be an essential factor in maintaining vitamin D at sufficient levels.
Probably vit D may stimulate the thyroid amongst other things so that less TSH gives the same T4/3 output. and the body then cooperates on its T4-T3 conversion to keep the status quo.
Available through Sci-jub but I will not post a link because it is claimed to be illegal and there are claims the Russians use it to hack data.
Not read it yet but it appears Vitamin D supplementation gives a moderate reduction in TBG antibodies. Both the treatment groups had lowish vitamin D (25.38 ng/ml and 19.8 ng/ml).
When I had my TT in October 2014, I was found to have Hurthle cell carcinoma and Hashimoto’s. I developed the lethargy and unexplained aches and pains after several weeks. My surgeon, when pushed for a possible reason for these symptoms, told me to take vitamins and in particular vitamin D. All my gp would say was ‘most people in Britain have a deficiency of vit D’. I did my homework and have been taking vit D3 and other supplements since. Yes I still have some issues but most definitely alleviated by D3. Really really wish the medical people would take notice!!!
Vitamin D has long been recognised as an immune modulator and given the known link between Hashi suffers and possible VDR gene polymorphisms, it makes sense to be mindful that our Vitamin D levels are kept optimum. Great paper. Thank you diogenes.
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