I came across the recent papers of this Polish group which may make for interesting reading. I myself will have to wade in and assimilate their meaning. Hope you find something in these of interest.
1. Krysiak R, Szkróbka W, Okopień B.
The Effect of Gluten-Free Diet on Thyroid Autoimmunity in Drug-Naïve Women with Hashimoto's Thyroiditis: A Pilot Study. Exp Clin Endocrinol Diabetes. 2018 Jul 30. doi: 10.1055/a-0653-7108. PMID 30060266. ncbi.nlm.nih.gov/pubmed/300...doi.org/10.1055/a-0653-7108
2. Krysiak R, Szkróbka W, Okopień B. The Relationship Between Statin Action On Thyroid Autoimmunity And Vitamin D Status: A Pilot Study. Exp Clin Endocrinol Diabetes. 2018 Aug 27. doi: 10.1055/a-0669-9309. PMID 30149415. ncbi.nlm.nih.gov/pubmed/301...doi.org/10.1055/a-0669-9309
3. Robert Krysiak, Karolina Kowalcze, Bogusław Okopień. SELENOMETHIONINE POTENTIATES THE IMPACT OF VITAMIN D ON THYROID AUTOIMMUNITY IN EUTHYROID WOMEN WITH HASHIMOTO’S THYROIDITIS AND LOW VITAMIN D STATUS. Pharmacological Reports 2018, ISSN 1734-1140, doi.org/10.1016/j.pharep.20...
4. Robert Krysiak, Witold Szkróbka, Bogusław Okopień. The effect of vitamin D and selenomethionine on thyroid antibody titers, hypothalamic-pituitary-thyroid axis activity and thyroid function tests in men with Hashimoto’s thyroiditis: a pilot study. Pharmacological Reports, 2018, ISSN 1734-1140, doi.org/10.1016/j.pharep.20....
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Both exogenous vitamin D and selenium reduce thyroid antibody titers. The aim of the study was to investigate whether the impact of vitamin D on thyroid autoimmunity is affected by selenium intake.
Methods
The study included 47 euthyroid women with Hashimoto’s thyroiditis and low vitamin D status, 23 of whom had been treated with selenomethionine (200 µg daily) for at least 12 months before the beginning of the study. During the study, all patients were treated with vitamin D preparations (4000 IU daily). Serum titers of thyroid peroxidase and thyroglobulin antibodies, as well as circulating levels of thyrotropin, free thyroid hormones and 25-hydroxyvitamin D were measured before vitamin D supplementation and 6 months later. Moreover, at the beginning and at the end of the study, we calculated Jostel’s thyrotropin index, the SPINA-GT index and the SPINA-GD index.
Results
With the exception of the free triiodothyronine/free thyroxine ratio and the SPINA-GD index, there were no differences between the study groups. In both groups, vitamin D increased 25-hydroxyvitamin D levels, reduced thyroid peroxidase and thyroglobulin antibody titers, as well as increased the SPINA-GT index. The effects on antibody titers and the SPINA-GT index were more pronounced in women receiving selenomethionine. Neither in selenomethionine-treated nor in selenomethionine-naïve women vitamin D affected serum hormone levels, Jostel’s index and the SPINA-GD index.
Conclusions
The results of the study suggest that selenium intake enhances the effect of vitamin D on thyroid autoimmunity.
Thank you for this very interesting study . I must also add that not everyone benefits from Selenium . Sometimes a good thing can be harmful as well . I was dosing with SELENOMETHIONINE . I did notice that my vitamin "D" levels where much higher so did my thyroid hormones go up . I also started having selenium toxicity itching skin break outs anxiety hair fall outs . I was on 200mcg Selenomethionine . I stopped using it and about 2 weeks later I felt relieved . My daughters glucose levels rose from Selenomethionine . Once she stopped Selenium her glucose levels returned to normal . Not everyone needs nor benefits from Selenium . It's possible that we get some from the foods we consume and that's enough for some of us .
Interesting, especially the first paper. I’ve got Graves and going totally GF for the last few years has drastically reduced my thyroid antibodies. So it works for Graves too.
There has been a bit of discussion about the benefits of reducing ones antibodies and whether it is worth doing. In my case I’m doing it because I’ve discovered it’s something I can do and I’m sure it must help - but as someone who works in that field what do you think? Would you want to reduce your antibodies if you had an autoimmune thyroid condition? Is it something that is likely to reduce the likelihood of Graves or Hashimotos flar8ng up again?
Does ‘drug naive’ mean that the patients are not taking any sort of drugs when the tests were being done?
If you still have some working thyroid left, then reducing AB status could delay further damage, but it won't stop it as long as ABs are present. With no thyroid left at all it won't matter what AB levels there are.
Although surely higher antibodies are present because your immune system is over sensitive/firing up unnecessarily? Surely avoiding this happening is the ideal ie mitigating the auto-immunity by avoiding gluten?
The reasons for anti-thyroid antibody production isn't absolutely clear, but it seems to come from accidental genetic clashes from outside influences (bacteria/viruses/food allergy etc) or childbearing. Avoiding things that might exacerbate the problem will help, but not prevent the antibodies being produced or their ultimate effects on the thyroid.
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Thyroid and vitamin d possible side effects
