T4 not being converted to T3: I have at last had... - Thyroid UK

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T4 not being converted to T3

VJW53 profile image
5 Replies

I have at last had a Genova test that confirms that I am not converting T4 to T3, and the reading for T3 is too low to measure. I had long suspected this is the case due to my worsening symptoms, but the NHS blood test always came back as okay.

Apart from taking selenium and zinc, is there anything that can be prescribed by my GP to get this sorted and get my life back on track? Any ideas gratefully received.

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VJW53
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humanbean profile image
humanbean

You'll have to post your results and reference ranges for anyone to be able to comment sensibly.

SlowDragon profile image
SlowDragonAdministrator

Essential to also test vitamin D, folate, ferritin and B12

As a vegetarian what vitamin supplements are you currently taking

Presumably you have Hashimoto’s?

Autoimmune thyroid disease diagnosed by high thyroid antibodies

Are you on strictly gluten free diet?

Please add thyroid and vitamin results and ranges

For full Thyroid evaluation you need TSH, FT4 and FT3 plus both TPO and TG thyroid antibodies tested. Also EXTREMELY important to test vitamin D, folate, ferritin and B12

Recommended on here that all thyroid blood tests should ideally be done as early as possible in morning and before eating or drinking anything other than water .

Last dose of Levothyroxine 24 hours prior to blood test. (taking delayed dose immediately after blood draw).

This gives highest TSH, lowest FT4 and most consistent results. (Patient to patient tip)

Is this how you do your tests?

Private tests are available as NHS currently rarely tests Ft3 or thyroid antibodies or all relevant vitamins

List of private testing options

thyroiduk.org/getting-a-dia...

Medichecks Thyroid plus antibodies and vitamins

medichecks.com/products/adv...

Thriva Thyroid plus antibodies and vitamins By DIY fingerpick test

thriva.co/tests/thyroid-test

Thriva also offer just vitamin testing

Blue Horizon Thyroid Premium Gold includes antibodies, cortisol and vitamins by DIY fingerprick test

bluehorizonbloodtests.co.uk...

If you can get GP to test vitamins and antibodies then cheapest option for just TSH, FT4 and FT3

£29 (via NHS private service ) and 10% off down to £26.10 if go on thyroid uk for code

thyroiduk.org/getting-a-dia...

monitormyhealth.org.uk/

Also vitamin D available as separate test via MMH

Or alternative Vitamin D NHS postal kit

vitamindtest.org.uk

VJW53 profile image
VJW53 in reply to SlowDragon

Thank you for this - I used the Genova Thyroid Plus test and had the results interpreted by a functional medic. I am now currently taking Ferrodyn, vitamin D3 and isoflavones, vitamin C, selenium, zinc and acetyl carnitine supplements. I am also unable to store vitamin D. I have been told that the low T3 and vitamin D is genetic. I am following a mainly gluten, dairy, sugar etc free diet. Christmas was a glitch but I'm getting back on track! Free T3 is outside the reference range, so T4, which is normal, presumably isn't converting to T3. There is rT3 production at .47. Thyroglobulin reading is very low at <32 and peroxidase is normal at 24. I guess I am hoping there is something I can be prescribed to take alongside the levothyroxine as all I really want is for my hair to stop falling out and my eyelashes to grow back - I can put up with all the other symptoms!

SlowDragon profile image
SlowDragonAdministrator in reply to VJW53

So how much levothyroxine are you currently taking

Do you always get same brand

When adequately treated Ft4 should be in top third of range

Please add actual results and ranges

Reverse T3 test is pretty useless (and expensive)

As a vegetarian it’s highly likely you have low ferritin/iron

And almost certainly low B12

As vegetarian it’s essential to supplement B12

On levothyroxine we need GOOD Vitamin D, folate, ferritin and B12 levels

Vitamin D at least around 80nmol and around 100nmol maybe better (that’s 40ng/ml)

Serum B12 at least over 500

Active B12 at least over 70

Ferritin and folate at least half way through range

SlowDragon profile image
SlowDragonAdministrator

What were your most recent results and ranges

TSH, Ft4 and Ft3

Do you always get same brand of levothyroxine

Before considering adding T3 Ft4 needs to be high in range and all four vitamins optimal levels

Frequently strictly gluten free diet helps or is essential

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