COVID-19 T3 Trial

[jimh111]

An interesting trial of T3 therapy for COVID-19 patients is being set up trialsjournal.biomedcentral... .

The trial uses large doses of T3. Although not as large as described in the trial summary. References to e.g. '0.8g/kg i.v' should refer to mcg!

The 'Full study protocol' document gives a better description on page 35. (I'm not going to read this 68 page document).

'For example, for a patient of 77Kg of weight, a dose of 6ml (60 μg) will be administered as a bolus intravenously over 2-3 min within 60 min of respiratory support initiation. Then, the patient for the next 24 hours will receive 21ml of the product (total of 210 μg of T3) that will be diluted in NaCl 0.9% and administered with a pump at a steady flow rate of 10.4 ml/h for a total duration of 48 hours. From day 3 till successful weaning or end of follow-up, the patient will receive 50% of this dose, 10.5 ml of the product (total of 105μg of T3)that will be diluted in NaCl 0.9% and administered with a pump at a steady flow rate of 5.2 ml/h.'

So, patients will typically receive a 60 mcg bolus L-T3 followed by 210 mcg daily for 3 days and 105 mcg thereafter.

THIS IS NOT AN INDEPENDENT STUDY.

'The Thy-Support trial will be entirely financially supported by Uni-Pharma S.A. (Greece) including materials used in this study. Uni-Pharma S.A. will have full oversight of the design of the study and collection, analysis, and interpretation of data and in writing the manuscript. The sponsor will also fund the CRO (PHARMASSIST) which will undertake collection, analysis, and interpretation of data in collaboration with a Data Monitoring Committee.'

We should expect bias in favour of L-T3 but it will be interesting to see the results.

[SlowDragon Administrator]

Have you seen the price of injectable T3???

[jimh111 in reply to SlowDragon]

Yes, but if it saved my life I wouldn't be bothered.

I forgot to mention I would be reluctant to volunteer for this particular trial, the intervention seems very agressive and adventurerous.

[Marz]

... Greek Docs are very poorly paid and during the financial crisis were not paid at all ... Not sure how they would run the trial without help.

[Marz]

... just another thought ! Uni-Pharma is a Greek company so they were keeping research in house ! Many of us have used and benefitted from UP T3 - it was only when people went to Greece and filled up their suitcases with OTC purchases that UP acted quite quickly to restrict T3. It then became prescription only for me and others in Crete and still is. Surely if they were BIG Pharma they would not have taken such steps.

Yeah ! I am pro Greece !!

[jimh111 in reply to Marz]

I suspect pressure was put on them by the rip-off phamaceutical comapanies. There is little true competition between large companies.

[Marz]

youtu.be/T4chpyTIE5Q(Not working as expected?)

Have to do this first ! See you there!

[jgelliss in reply to Marz]

Marz Thank You for this Amazing dance. Many of us are left with smiles on our face and wishing we can do it too.

[Marz in reply to jgelliss]

Did the link work for you ?

[jgelliss in reply to Marz]

Oh Yes. In fact I watched a few times. I loved it. Even though it took place three years ago it's still *Amazing*. It's a great work out. That's if we would only be able to do it. Marz Thank You For Sharing it with us. It took our minds off for a little while from our *Thyroid Matters*.

[serenfach in reply to jgelliss]

I stuck my arms out, kicked one leg and knelt down....and decided to stay there for a bit....quite a long bit

[Zephyrbear in reply to Marz]

Link worked for me! Absolutely fabulous!!!

[mrsm49 in reply to Marz]

How lovely Marz, it reminded me of the many Greek holidays I've had and hope to again one day. If only i was as fit..or as bendy 🤣 x

[Marz]

Oh dear the wrong video appears - sorry ! Google Russian Ballet and Greek Dance x

[greygoose in reply to Marz]

lol

[Marz]

Technology sadly passes me by ! Bit like those med students who go to the loo and miss the thyroid lecture !

[aspenca]

Homoeoprophylaxis (HP) and Nosodes the Cuban study 2007. All homeopaths are aware of this but you will not hear it discussed on any major news media...It's all about vaccines/vaccines/vaccines/vaccines....

littlemountainhomeopathy.co...

dogsnaturallymagazine.com/n...

[FancyPants54]

As soon as we started hearing about long tail Covid, with bouts of fatigue and inability to recover, I started hoping someone was looking at these poor people’s thyroid output. If this means doctors will start looking, it’s good.

[jimh111 in reply to FancyPants54]

I plan to post about a study that addresses this within a week. I want to prepare it well before posting.

[penny]

I keep on hearing about an obesity problem and thinking ‘why don’t they test all the thyroid hormones and review ranges?’

[jimh111 in reply to penny]

The 'ranges' are 95% reference intervals and show where 95% of the healthy population lie although they could do a better job of selecting healthy subjects. It's sensible to test TSH, fT3 and fT4 as they are cheap assays. The problem arises in interpretation, they are treated as if they were independent variables which they are not. An added complication is that TSH are a group of isoforms (molecules) with varying activity, just measuring their immuno-response is not always reliable.

I think obesity is largely a lifestyle problem. When I look at people of e.g. African descent in the UK and compare them to those in France there is a considerable difference in obesity levels. This suggests it is our UK lifestyle that is the major contributor to obesity. Of course thyroid disorders contribute but other developed countries such as Singapore do not have the same levels of obesity.

[penny in reply to jimh111]

I agree, but it would be a start, not difficult to do and would probably save the nhs a great deal of money.