The trial uses large doses of T3. Although not as large as described in the trial summary. References to e.g. '0.8g/kg i.v' should refer to mcg!
The 'Full study protocol' document gives a better description on page 35. (I'm not going to read this 68 page document).
'For example, for a patient of 77Kg of weight, a dose of 6ml (60 μg) will be administered as a bolus intravenously over 2-3 min within 60 min of respiratory support initiation. Then, the patient for the next 24 hours will receive 21ml of the product (total of 210 μg of T3) that will be diluted in NaCl 0.9% and administered with a pump at a steady flow rate of 10.4 ml/h for a total duration of 48 hours. From day 3 till successful weaning or end of follow-up, the patient will receive 50% of this dose, 10.5 ml of the product (total of 105μg of T3)that will be diluted in NaCl 0.9% and administered with a pump at a steady flow rate of 5.2 ml/h.'
So, patients will typically receive a 60 mcg bolus L-T3 followed by 210 mcg daily for 3 days and 105 mcg thereafter.
THIS IS NOT AN INDEPENDENT STUDY.
'The Thy-Support trial will be entirely financially supported by Uni-Pharma S.A. (Greece) including materials used in this study. Uni-Pharma S.A. will have full oversight of the design of the study and collection, analysis, and interpretation of data and in writing the manuscript. The sponsor will also fund the CRO (PHARMASSIST) which will undertake collection, analysis, and interpretation of data in collaboration with a Data Monitoring Committee.'
We should expect bias in favour of L-T3 but it will be interesting to see the results.
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jimh111
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... just another thought ! Uni-Pharma is a Greek company so they were keeping research in house ! Many of us have used and benefitted from UP T3 - it was only when people went to Greece and filled up their suitcases with OTC purchases that UP acted quite quickly to restrict T3. It then became prescription only for me and others in Crete and still is. Surely if they were BIG Pharma they would not have taken such steps.
Oh Yes. In fact I watched a few times. I loved it. Even though it took place three years ago it's still *Amazing*. It's a great work out. That's if we would only be able to do it. Marz Thank You For Sharing it with us. It took our minds off for a little while from our *Thyroid Matters*.
Homoeoprophylaxis (HP) and Nosodes the Cuban study 2007. All homeopaths are aware of this but you will not hear it discussed on any major news media...It's all about vaccines/vaccines/vaccines/vaccines....
As soon as we started hearing about long tail Covid, with bouts of fatigue and inability to recover, I started hoping someone was looking at these poor people’s thyroid output. If this means doctors will start looking, it’s good.
The 'ranges' are 95% reference intervals and show where 95% of the healthy population lie although they could do a better job of selecting healthy subjects. It's sensible to test TSH, fT3 and fT4 as they are cheap assays. The problem arises in interpretation, they are treated as if they were independent variables which they are not. An added complication is that TSH are a group of isoforms (molecules) with varying activity, just measuring their immuno-response is not always reliable.
I think obesity is largely a lifestyle problem. When I look at people of e.g. African descent in the UK and compare them to those in France there is a considerable difference in obesity levels. This suggests it is our UK lifestyle that is the major contributor to obesity. Of course thyroid disorders contribute but other developed countries such as Singapore do not have the same levels of obesity.
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normal TSH and T3 but Low T4
More or less T4 with T3?
My stubborn T4 finally on range but still high T3
