Protocol for carrying out D102 test

[Veritate]

Good afternoon everyone.

I wondered, for the people who’ve carried out the D102 test, what the protocol was? I take only NDT at present and wanted to know if I need to miss a dose for the test or simply take as normal?

Thanks for your help peeps 😊

[helvella Administrator Thyroid UK]

For clarity, the gene that affects T4 to T3 conversion is called DIO2 - that is, three letters and a number. Not D102 - a letter and three numbers. Not DI02 - two letters and two numbers.

The name comes from the enzyme that this gene affects which is a deiodinase. It removes an iodine atom from a thyroid hormone molecule - it deiodinates it.

On this forum we probably understand, but if you wish to look it up anywhere, it might help to get it right. If you are discussing with a doctor, and get it wrong, you are providing an excuse for them to dismiss what you say.

(More strictly, two single-nucleotide polymorphisms (SNPs) on the DIO2 gene, rs225014 and rs225015.)

academic.oup.com/jcem/artic...

The Wiki article provides a basic introduction as to what a single-nucleotide polymorphism (SNP) is and why it can be important:

en.wikipedia.org/wiki/Singl...

[Veritate in reply to helvella]

Thank you for your reply and clarification. I did start to have a look into DIO2 and will certainly look at the links you sent. Thank you for your help, it’s much appreciated 😊

[SlowDragon Administrator]

It’s a test of your DNA ...saliva

thyroiduk.org/tuk/testing/D...

thyroiduk.org/tuk/testing/D...

Thyroid levels don’t affect it

I think possibly you need to stop B vitamins few days before test ...it will say in instructions

Does require quite a lot of spit...so allow about 20 mins to do test

Takes about 2-3 weeks to get results

[Veritate in reply to SlowDragon]

That’s great, thanks for the tips 👍🏻