What’s the correct way to switch from taking my synthroid at 6am to start taking it at night?
Let’s say I took the pill today at 6am, do I take it again at night and start today or do I have to wait till tomorrow and skip the usual time at 6am and start taking it at night?
I started taking it later in the day each day for several days.
You could also take half in morning and half at night. Then just switch to all at night.
it doesn't matter, Levo is very long acting, you have 5 to 7 days floating around your body if you are optimal
When I changed, I just didn't take it that morning and took the whole dose at bedtime. I didn't experience any problems doing it that way.
I just took first half this morning I will take second half tonight and make the full transition tomorrow night. Thanks everyone for the replies
Ralph1985, As others have mentioned, if doesn't matter too much how you do it, as this is a slow acting treatment.
When I was very undermedicated I struggled to do it, and found I got on much better by taking both the morning and evening dose on the day of switching. Lalatoot's suggestions are also good as very gentle ways of doing it. But I think you only need to bother with any of these if you're very sick or if you suspect you're super sensitive to dosing.
The hard part is making sure you have an empty stomach when you go to bed. (So that you cana absorb the medication efficiently) Most people eat their largest meal in the evening, it takes most of your sleeping hours to digest it and empty your stomach for the next day.
Does it make a difference taking levothyroxine at night?
It is often suggested that bed-time dosing results in slightly better absorption. It also seems slightly closer to the pattern helthy people have.
We have some who prefer it; we have others who prefer other times. See our poll:
healthunlocked.com/thyroidu...
Some papers which discuss taking levothyroxine at different times - such as bed-time.
Levothyroxine Replacement and Ramadan Fasting
pubmed.ncbi.nlm.nih.gov/237...
Effect of L-Thyroxine Administration Before Breakfast vs at Bedtime on Hypothyroidism: A Meta-Analysis
pubmed.ncbi.nlm.nih.gov/320...
Morning vs. Bedtime Levothyroxine Administration: What Is the Ideal Choice for Children?
pubmed.ncbi.nlm.nih.gov/303...
A Crossover Study Evaluating Effect of Timing of Levothyroxine on Thyroid Hormone Status in Patients of Hypothyroidism
pubmed.ncbi.nlm.nih.gov/313...
Effect of Timing of Levothyroxine Administration on the Treatment of Hypothyroidism: A Three-Period Crossover Randomized Study
pubmed.ncbi.nlm.nih.gov/300...
Alternative Schedules of Levothyroxine Administration
pubmed.ncbi.nlm.nih.gov/256...
Thyroid Diseases and Ramadan
pubmed.ncbi.nlm.nih.gov/228...
Pharmacotherapy: Hypothyroidism-Should Levothyroxine Be Taken at Bedtime?
pubmed.ncbi.nlm.nih.gov/213...
Effects of Evening vs Morning Levothyroxine Intake: A Randomized Double-Blind Crossover Trial
pubmed.ncbi.nlm.nih.gov/211...
Timing of Levothyroxine Administration Affects Serum Thyrotropin Concentration
pubmed.ncbi.nlm.nih.gov/195...
Effects of Evening vs Morning Thyroxine Ingestion on Serum Thyroid Hormone Profiles in Hypothyroid Patients
pubmed.ncbi.nlm.nih.gov/172...
Wow! Thank you for your comprehensive reply. I’ll have a good read of all of those and make a decision. I’ve just started to introduce thyroxine again after being on T3 only for 3 years. Previous to T3 only I was in NDT and then Levo prior to that. I was so run down and generally unwell on both but particularly on Levo. Thanks to all the good advice on here I now have good nutrient levels. I’m working towards optimal T4 and T3 levels now. I want to take me medication in the best way possible. Thank you again for all of this information.
Afraid I cannot answer from personal experience of changing because I have always taken my levothyroxine at bed-time (and do not take T3). 
Thank you Helvella. I wish I didn’t have to take it. It’s so stressful trying to get T3.
I wish I’d discovered this forum long again. I’ve had an underactive thyroid for 22 years and I’m now 44. I’m beginning to get myself on the road to good health now! The advice of this forum is invaluable.
Thank you for taking time out of your day to help me. It’s greatly appreciated.
Switching from Levothyroxine to NDT
Switching to Armour from Levothyroxine
Switching from T3 to T4
