I was doing my usual trawl for Vit D protocol updates and came across this from 2009. Nothing has changed in 11 years but the conclusion of the study suggests that many thousands of people could have escaped the misery of MS.
MS is a devastating neurodegenerative disease that imposes heavy burdens on patients, on families, and on health care systems throughout the world. At an estimated lifetime cost in excess of $2.2 million per MS case, the implications of the sustained increases in female cases to the world’s strained health care systems are staggering (28). In this context, it is encouraging that modifiable environmental factors appear to set the disease threshold and may hold the key to preventing the vast majority of MS cases (6). Sunlight exposure and vitamin D3 supplies appear to be those modifiable environmental risk factors (9, 13). If health care providers were to monitor serum 25-(OH)D3 levels, especially in girls and women who are genetically related to an individual with MS, and prescribe enough sunlight exposure and/or vitamin D3 supplementation to maintain >100 nmol/L of serum 25-(OH)D3 throughout the year, an estimated 90% of MS cases might be prevented (15). For men and women already afflicted with MS, intermittent 1,25-(OH)2D3 pulse dose therapy (F. E. Nashold, R. A. Derks, and C. E. Hayes, manuscript in preparation) in the context of sufficient natural E2 in young women or E2 replacement therapy in postmenopausal women might activate antiiinflammatory mechanisms that drive MS disease into remission and significantly decrease the cumulative disability. The overwhelming body of evidence suggests that these intervention strategies could dramatically reduce the impact of MS on patients, on families, and on our health care systems.