T3 Implant - Titan Pharma: Happy Friday :) I... - Thyroid UK

Thyroid UK

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T3 Implant - Titan Pharma

17 Replies

Happy Friday :)

I have found this online: titanpharm.com/pipeline/t3-...

Not sure how great this could be, but judging by description - I would love to try it! Who knows how long it takes to get this to the market, if this even happens, of course :)

x

Cuppa

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17 Replies
NWA6 profile image
NWA6

Wow! That sounds amazing! Going along the lines of the insulin implants.

in reply to NWA6

Exactly! They already have one product on the market and it's getting many positives!

NWA6 profile image
NWA6 in reply to

A T3 one? My friends child (19yrs) is just going through the process of having her an insulin pump fitted.

in reply to NWA6

No no, a different one, not t3. Oh wow...that's pretty cool.

RedApple profile image
RedAppleAdministrator

This idea has always seemed to me to be the most obvious solution to our problems. I wonder why they are focussing on T3 only though, rather than T4 as well. After all, our thyroid does not pump out a single once daily dose of T4. So why not go the 'whole hog' and try to replicate the working thyroid, rather than just one of the hormones.

Focussing only on T3 might mean it never gets to market, because so many medics are determined to stick with the outdated theory that adding T3 as a daily thyroid hormone replacement, is not remotely necessary.

in reply to RedApple

I also think we should have both, t4 and t3, in this format, bypassing the stomach - celiac issues, low stomach acid etc etc my question is - how can you test a dose, would they give us a test implant for 6-8 weeks or how would this work? :)

RedApple profile image
RedAppleAdministrator in reply to

Yes, interesting point. Maybe start on oral administration until a reasonable dose is achieved (e.g. to get TSH,T4 and T3 to approximately the right place for the individual patient). Then switch over to comparable dose implant. Comparable dose may not mean the same doses if the implant dosing was more efficient. It would take some time to get to the right place, but that's the case anyway even with tablets.

in reply to RedApple

Absolutely, I can't wait for the day we have an alternative treatment to pills. I am also curious if anyone thoughts of a transdermal t3/t4? Or is it different to other female hormones? Would be happy to carry a sticker :)

RedApple profile image
RedAppleAdministrator in reply to

No, transdermal doesnt work for thyroid hormones. See helvella comments somewhere on this (rather long) thread healthunlocked.com/thyroidu...

in reply to RedApple

Interesting, I've read it, but I'm not sure why they don't work ? Couldn't see explanation anywhere. Either way, I'd prefer an implant! :)

RedApple profile image
RedAppleAdministrator in reply to

I think the molecules are too large to penetrate transdermally - or something like that anyway. I'm not good at chemistry :D - helvella might be able to explain.

helvella profile image
helvellaAdministratorThyroid UK in reply to

As I understood it (but that is a bit hopeful in itself!), levothyroxine alone does not absorb into skin anywhere near well enough. If they manage to adjust things so that the levothyroxine can be absorbed, it then gets stuck in the skin cells it transfers into, and does not then enter the bloodstream and get circulated.

In the unlikely event you were trying to treat a patch of hypothyroid skin, it might work. If you are trying to treat a whole person, not a chance. At present.

RedApple

in reply to helvella

Thanks helvella, interesting! Maybe there has to be a better carrier for levothyroxine, I really don't know anything about it though :) I'm just excited at any perspective of alternative treatment to pills!

in reply to helvella

Just read it takes 12-18 years to progress from preclinical to market and only 5 in 5000 drugs make it 😂🙃😀💪

TSH110 profile image
TSH110 in reply to

At least this drug has a track record already

thyr01d profile image
thyr01d in reply to RedApple

I'd guess the answer is because it's easy enough to take one tablet per day, as we can do with T4, but actually quite tricky to manage the T3, if, like me, you need 4 small doses a day (I go way over the top on fewer doses) and need to take magnesium and/or iron 4 hours away as many people need. As a Yoga teacher I also need to leave 1 hour before classes without eating and used to drink coffee to get through the long hours without food which isn't easy as a vegan (supposed to graze all day) but we can't have coffee within an hour of the T3 either. 4 a day sounds easy but when you try to do it practically it's impossible some days.

TSH110 profile image
TSH110 in reply to RedApple

It is far more predictable and easily assimilated than T4 so perhaps that is why? My other thought is perhaps heart disease rather than hypothyroidism is the end game?

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