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[Minimouse1]

‘ High Antibodies but ‘NormalTSH, T4, and T3 Levels:

HomeArticleAbout TSH Controversy‘ High Antibodies But ‘NormalTSH, T4, And T3 Levels:

Should You Undergo Thyroid Hormone Therapy?

Dr. John C. Lowe

In this newsletter, I address a question I often receive from readers of

drlowe.com” target=”_blank” class=”bb-url”>drlowe.com”>drlowe.com The writers’ words differ a bit, but over-and-over again, they ask the same question, so I thought it appropriate to publish my general answer here.

The oft-asked question goes something like this:

“I have very high thyroid antibodies, but my TSH, T4, and T3 are normal. I have many hypothyroid symptoms and my basal body temperature is extremely low, usually 96.7 degrees Fahrenheit (35.94 degrees Celsius). But my doctor says the antibodies are not that important and that I do not need to take thyroid hormone.

Do you agree with him or not?”

My answer is always the same: I resoundingly do not agree with the doctor. First, as my wife Tammy recently said, consider the prefix to the term “anti-bodies.” The prefix means “against,” and just like anti-freeze prevents your car’s radiator from freezing, anti-bodies against your thyroid gland, if they stay high, will, sooner or later, prevent the gland from working normally. Your symptoms and your extremely low basal body temperature strongly suggest to me that your gland is already impaired.

How do we know if the thyroid gland has been damaged? Not necessarily by measuring your TSH, T4, or T3 levels. The levels of these hormones may be in range or out. The blood levels just aren’t reliable enough to tell us whether a person has sufficient thyroid hormone for his or her cells to function normally. The endocrinology specialty and its corporate sponsors wish with all their might that these tests were the ultimate gauges. But, alas, they definitely are not!

The TSH, T4, and T3 levels vary dramatically every thirty minutes.[1][2][3][4] Because of this extreme variance, unless the levels are far out of range, they are inaccurate criteria for inferring whether your tissues have enough thyroid hormone regulation. I have done hundreds of measurements of patients’ resting metabolic rates. Some patients were taking thyroid hormone and others not.

For patients with low metabolic rates, I have done differential diagnoses to learn the most likely cause of the low rates. The most likely cause for most of them has been too little thyroid hormone regulation. I know from statistical analyses of the data from these evaluations that the TSH, T4, and T3 levels do not reliably predict which patients do and do not have too little thyroid hormone regulation.

High thyroid antibodies are important in and of themselves. Because yours are high, you should be motivated to get them back down into their reference ranges. If a patient’s antibodies stay high, they may eventually cross-react with a tissue other than the thyroid gland. The patient will then have autoimmune disease of both the thyroid gland and the other tissue.

I find antibody tests much more useful than the TSH, T4, or T3. High antibodies indicate that a patient’s symptoms are from too little thyroid hormone regulation when the TSH, T4, or T3 fail to do so. Consider a 1996 study by Aarflot and Bruusgaard.[5] They included 737 men and 771 women in their study. Men and women who had chronic widespread musculoskeletal pain (often diagnosed as “fibromyalgia”) had a higher incidence of thyroid antibodies than men and women who didn’t have pain. But the TSH, T4, and T3 levels of the two groups of men and women did not differ.

My research is now complete in showing that fibromyalgia symptoms are caused mainly by too little thyroid hormone regulation. In view of this, Aarflot and Bruusgaard’s finding indicates that antibody tests show too little thyroid hormone regulation while the TSH and thyroid hormone levels often fail to do so.

As the well-known thyroid specialist Dr. Robert Volpé has written, the TSH, T4, and T3 levels may be “normal” for years despite patients having autoimmune thyroiditis the whole time.[6]

You can have more confidence in your need for thyroid hormone therapy if you have one or more of the physiological abnormalities common among hypothyroid patients. The abnormalities include (1) a low basal body temperature, which you have; (2) a basal pulse rate too low for your level of cardiovascular conditioning; (3) a slow relaxation phase during your Achilles reflex; and (4) a low voltage R wave in the QRS complex of your EKG.

Of course, you can measure your temperature and pulse rate at home. Hopefully your doctor will cooperate by testing your Achilles reflex and measuring the voltage of your R wave. When patients come to our clinic, we also do the most important test of all the resting metabolic rate, and we measure the composition of their bodies. We measure body composition so that I know the patients’ lean body weight. I use the measurement in an equation to learn what his or her metabolic rate should be. Then, when we measure the patient’s actual metabolic rate, I can calculate how low it is compared to what it should be.

The body composition measurement is important for another reason: so that I can decide whether the patient has a sign common among hypothyroid patients. This sign is too much body fat for the patient’s diet and physical activity level.When patients come to our clinic, we have the advantage of being able to observe them in person.

The reason this is valuable is that if a doctor has learned the physical signs of hypothyroidism,[7] he or she can usually tell a lot about a patient’s thyroid status just by observing the patient first hand.

Considering what I said above, I hope that one thing is clear: whether you come to our clinic or not, you can accumulate evidence that should convince any reasonable doctor that you probably have too little thyroid hormone regulation. If that evidence exists, then a trial of thyroid hormone therapy – although not T4 – replacement is in order.

Remember that the TSH, T4, or T3 don’t reliably tell you whether you do or don’t need treatment. So, if you let your doctor deny you a trial of thyroid hormone therapy because of reference range levels of these tests, you’ll be allowing him or her put your health and well-being at risk. I personally wouldn’t let an uninformed doctor subject me to that.

[diogenes Remembering]

I don't know where the idea that T4, T3 and TSH change rapidly every 30 minutes comes from, but it is demonstrably wrong as regards both FT4 and FT3 in health. TSH is certainly more variable over the 24 hours but the principal changes occur in the night. FT3 only changes by about 10%, an hour or so after the TSH spike, and then returns to its usual steady state. We all have our own "set point" of FT4, FT3 and TSH when healthy which predicts the levels of hormone someone will need when therapy starts. With a failed thyroid, on T4 mono therapy, TSH doesn't change as much on a given dose, and FT4/FT3 have small variations over the day. With T3 monotherapy on the other hand, the FT3 varies strongly over the day, with shortlived spikes after taking a tablet. I don't therefore agree that measurement of thyroid hormones is unimportant. It is essential for finding the "sweet spot" of optimal therapy, but measurements need only be done occasionally afterwards to check all is well. Patients with antibodies against thyroid tissue will suffer undulating values of hormones whilst the antibody attack is underway, but once the thyroid is entirely lost, they have no further effect on hormone levels from tablets taken by mouth.

[Minimouse1 in reply to diogenes]

So as TSH, T4,T3 & all vitamins become optimal do we usually find the antibodies calm down?? I have a rash on one lower arm at the moment & a tight sore throat & generally feeling washed out over last few days. I have been told this can be as a result of antibodies. I'm aking 100mg of levo. Blood results etc. are now in range but at top end. I had these checked yesterday after publishing in another link on this site.

[diogenes Remembering in reply to Minimouse1]

Not necessarily. The antibody attack isn't modulated by the thyroid hormones, but is a separate matter altogether, and causes lack of thyroid hormone production. So the attack can go on until the gland is dead or it might linger for some time. There is no telling generally.

[Minimouse1 in reply to diogenes]

Oh dear. I thought being on the correct meds would resolve matters. The gluten free diet doesn't seem to have helped yet but I'll give it a little longer & then if no better may have to look at dairy too. Wish there was a simple test which would pinpoint the cause of antibodies!! Thanks for the advice.