Just got my results back and was wondering if anyone can decipher what they mean?
It seems as though I don’t have an issue with the DI02 gene but there are some other things highlighted.
I’m wondering if these show anything that be worth discussing with an endo, to back up my taking/need for T3?
Any help appreciated, my mind can’t focus today 😩 TIA
Sorry......This photo isn't readable
Some other DNA posts
healthunlocked.com/thyroidu...
Sorry, I didn’t realise! I could only post one photo, so tried to squeeze them in. I’ll try posting again. Thanks. I’ll also have a look at the links 😊
I've tried to put all the results here...as you can see, not easy reading. I'm just trying to work out what this means in real/everyday life terms. I think I will email Blur Horizons to try and get clearer explanation too but any help in the meantime would be really appreciated. Thanks 
Your thyroid genotype and advice:
GENE RESULT IMPACT & ADVICE
AMBER: COMT - Inactivation of Stress Hormones and Oestrogen
COMT is one of the main inactivating enzymes of stress
hormones and oestrogen in the body. COMT variants cause
slow clearance of stress hormones and oestrogen leading to
high oestrogen and stress hormone levels which may also be
linked to thyroid hormone dysfunction. - AG -
Slow clearance of stress hormones and oestrogen. You may
be at increased risk of thyroid dysfunction when under stress
and due to poor elimination of oestrogen.
GREEN & AMBER: DIO1 - Thyroid Hormone Activation
“D1” is largely expressed in the liver and kidneys.
It is
responsible for the clearance of rT3 from circulation, and for
facilitating the conversion of T4 to T3 in plasma and
surrounding tissue. This process requires selenium and iodine
for optimum function. Here we look at two variants linked to
poor conversion of T4 to T3 and reduced clearance of rT3. -CA
-
The 'C' result is associated with increased DIO1 gene function
resulting in rapid conversion of FT4 to T3 and reduced
circulating rT3 levels. Ensure adequate iodine and selenium
intake to support this pathway optimally. - TC
-
Likely to have lower DIO1 activity and therefore probably
decreased clearance of rT3 from circulation, and lower
conversion of T4 to T3. Ensure adequate intake of iodine and
selenium to support this pathway.
GREEN: DIO2 - Thyroid Hormone Activation
“D2” is importantly expressed in the central nervous system,
pituitary, brown fat tissue and muscle, and responds to
changes in thyroid levels. D2 is responsible for the ‘local’
conversion of T4 to T3 in the thyroid, placenta and brain. It
requires selenium and iodine to function optimally. Here we
look at two different variants linked to decreased T4 and low
mood in certain individuals.- TT
-
Linked to normal enzyme activity and not with increased risk
of anxiety and depression if taking thyroxine (T4) hormone
replacement therapy for hypothyroidism -TC-
The 'T' result is associated with increased DIO2 activity. This
has been shown to present as lower T4 and rT3, and higher T3
levels. Adequate levels of iodine and selenium are required
for optimal functioning of this pathway.
GREEN: FKBP5 - Cortisol Regulation
FKBP5 is an important stress-regulating gene responsible for
lowering cortisol levels after a stress response. Variants are
associated with prolonged and increased symptoms of stress,
which may be due to delayed lowering of cortisol levels. -CC-
Healthy cortisol regulation and stress resilience. You are likely
to be less negatively affected by stress and the impact it has
on the body. Thyroid hormone regulation is likely to be less
affected also.
AMBER: PDE8B - TSH Signalling
PDE8B is found in the thyroid but not the pituitary, and is
involved in TSH signalling. It is thought that the variant
decreases the response of the thyroid gland to TSH
stimulation. -GA-
You may be susceptible to reduced thyroid sensitivity to TSH
stimulation which could result in a need for and production of
higher TSH levels in order to produce normal levels of thyroid
hormones (T4 and T3).
GREEN: TNF-a - Inflammation
TNF-a is an inflammatory cytokine that helps regulate the
immune reaction involved in inflammation, giving rise to fever
and inhibiting tumour growth. If poorly controlled, it may be
implicated in a number of autoimmune disorders. Variants in
TNF-a are associated with overreactive immune responses
and prolonged inflammation.- GG-
Not genetically predisposed to overreactive inflammatory
immune response. This means you are less likely to suffer from
chronic inflammation or be at increased risk of developing
autoimmune conditions - including Hashimoto's thyroiditis or
Graves' disease. It is still important for you to manage stress,
and follow a healthy diet and exercise regime to keep your
risk low.
AMBER: TSHR - Thyroid Stimulating Hormone (TSH) Receptor
The TSHR gene plays a central role in thyroid metabolism by
controlling the thyroid gland’s receptivity to TSH. Variants in
this gene have been linked to hyperthyroidism, particularly to
Graves’ Disease (GD).- GA-
The 'A' result has been found to be more common in people
with Graves' Disease and is linked to the presence of thyroid
stimulating hormone receptor antibodies (TRAb), associated
with increased risk of developing GD.
RED: TRHR - Thyrotropin Releasing Hormone (TRH) Receptor
Responsible for the body’s receptivity to TRH which stimulates
the secretion of TSH from the pituitary gland. In turn, TSH
stimulates the production of thyroid hormones from the
thyroid gland. TRH is an important part of the negative
feedback loop that ultimately regulates thyroid hormone
levels. Variants have been shown to affect TSH levels-
GG-
The 'G' result has been associated with a less responsive
negative feedback mechanism. Carriers of this genotype may
show higher circulating TSH:T3/4 ratio due to delayed
reduction of TRH and TSH in the presence of healthy thyroid
hormone levels. This may mean that the body is subjected to
a less efficient response to changing thyroid hormone
requirements.
I had this test done and found the explanations utterly rediculous. It appears that they have tried very hard to simplify the result but have tied themselves in knots instead..
I was only really interested in the D2 result which turned out to be the CC genotype which indicates poor conversion inherited from both parents.
I ended up doing some internet searches in order to make some. sense of it
The following may be useful
healthunlocked.com/thyroidu...
Good luck
Too small to read.
Ok no worries
Blue Horizon Test Results
Blue Horizon test results
Blue Horizon blood test - advice please
Blue Horizon Results
