I was hoping to get some advice from this amazing forum:

I am now exclusively on T3 at 60mcg per day on the advice of my endo and psychiatrist after stopping NDT on which I felt much better in myself, however I had to keep raising the NDT doses to maintain my T3 on the upper end of the range on which I feel much better. I confess I don' think being on exclusive has resolved my problems as I still feel very lethargic. Whilst my hair has now stopped falling out, I have also gained around 5kg since stopping NDT and moving to exclusive T3, which is upsetting me a great deal.

When my period was late, my endo tested my female hormones and found my oestrogen to be over 2000. This is way over the max of the mid cycle range which is circa 1200.

I have done some research since then and discovered that T3 meds can apparently lead to oestrogen dominance, which in turn causes water retention and weight gain, depression and anxiety and fatigue. So it's now the proverbial chicken and egg problem..

Aside from weight gain, I am even more concerned since my late mother passed away from secondary oestrogen dominant related breast cancer..

Any advice or wisdom very gratefully received.