I had thyroid genetics test done a few months ago by Blue Horizon, I think thy actually covered more than the Regenerus Lab and also don't charge for, or provide counselling, however my questions were answered in detail by their expert who was really helpful. Genetically I lack "optimal" conversion for T4 - T3 at both DIO1 & DIO2, but don't have the gene which can cause serious psychological issues due to faulty conversion. However my T4:T3 ratios can be unbalanced, and my TSH signalling is faulty (flagged red) explained as;
"You may be susceptible to reduced thyroid sensitivity to TSH stimulation which could result in a need for and production of higher TSH levels in order to produce normal levels of thyroid hormones (T4 and T3)"
After a quick Google I also discovered that my TSH will be at a (slightly) higher than than other genotypes. I found a few articles, mostly looking at subclinical Hypothyroidism in pregnancy;
QUOTE <"A number of genes have recently been identified that are associated with altered thyroid function in the normal population (7–9). The single nucleotide polymorphism (SNP) rs4704397 in the phosphodiesterase 8B (PDE8B) gene shows an association with circulating TSH levels, explaining 2.3% of the variance in TSH in the general population (7). Each copy of the minor A allele was found to be associated with an increase in TSH concentration of 0.13 mIU/liter, an effect size equating to around a 0.42 SD difference between the AA and GG genotypes.
This genetic variation in TSH concentrations, within the normal population, is likely to result in altered “normal ranges” for the three different genotypes. We aimed to assess whether this difference would affect the number of individuals classified as having subclinical hypothyroidism, who would, therefore, potentially be treated with T4 in pregnancy based on the current guidelines." >
Interestingly, it recommended routine thyroid checks for all pregnant women!
What this means my normal TSH should be I don't know!! My thyroid wasn't likely to be responding adequately to TSH stimulation before, and now for years my bodies making matters worse with attacks from both TPO and TG antibodies (and yes I have gone gluten free and the TPO (only) seems to be reducing, slowly )