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Thyroid UK
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Advice please

Hi I am new, I am 31 years old and hoping to get some advice here about my most recent results. I have low DHEA (found in August 2017) and hypothyroidism (found in June 2014). Please see below bloods. I take 175 mcg levothyroxine and my hands are very cold, I am forgetful, tired, constipated, shivering internally, aches in joints, dry skin, flaky and splitting nails, weight gain. I take my tablets on an empty stomach 2 hours away from food, 4 hours away from supplements and I take no other medications.

Thank you

December 2017 (175 mcg levothyroxine)

TSH *4.69 (0.2 - 4.2)

FT4 14.6 (12 - 22)

FT3 3.5 (3.1 - 6.8)

TPO antibodies *446.3 (<34)

TG antibodies *685.1 (<115)

DHEA *2.3 (2.7 - 7.5)

3 Replies

You are under medicated to have TSH so high. FT4 should be near top of range and FT3 at least half way in range

All thyroid tests should be done as early as possible in morning and fasting and don't take Levo in the 24 hours prior to test, delay and take straight after. This gives highest TSH, lowest FT4 and most consistent results

Is this how you did test?

Ask GP for 25mcg dose increase.

Your antibodies are high this is Hashimoto's, (also known by medics here in UK more commonly as autoimmune thyroid disease).

About 90% of all hypothyroidism in Uk is due to Hashimoto's

Essential to test vitamin D, folate, ferritin and B12.

Always get actual results and ranges. Post results when you have them, members can advise

Hashimoto's affects the gut and leads to low stomach acid and then low vitamin levels

Low vitamin levels affect Thyroid hormone working

Poor gut function can lead leaky gut (literally holes in gut wall) this can cause food intolerances. Most common by far is gluten

According to Izabella Wentz the Thyroid Pharmacist approx 5% with Hashimoto's are coeliac, but over 80% find gluten free diet helps significantly. Either due to direct gluten intolerance (no test available) or due to leaky gut and gluten causing molecular mimicry (see Amy Myers link)

But don't be surprised that GP or endo never mention gut, gluten or low vitamins. Hashimoto's is very poorly understood

Changing to a strictly gluten free diet may help reduce symptoms, help gut heal and slowly lower TPO antibodies

Ask GP for coeliac blood test first








Dr Toft, past president of the British Thyroid Association and leading endocrinologist, states in Pulse Magazine,

"The appropriate dose of levothyroxine is that which restores euthyroidism and serum TSH to the lower part of the reference range - 0.2-0.5mU/l.

In this case, free thyroxine is likely to be in the upper part of its reference range or even slightly elevated – 18-22pmol/l.

Most patients will feel well in that circumstance. But some need a higher dose of levothyroxine to suppress serum TSH and then the serum-free T4 concentration will be elevated at around 24-28pmol/l.

This 'exogenous subclinical hyperthyroidism' is not dangerous as long as serum T3 is unequivocally normal – that is, serum total around T3 1.7nmol/l (reference range 1.0-2.2nmol/l)."

You can obtain a copy of the articles from Thyroid UK email print it and highlight question 6 to show your doctor

please email Dionne:


Yes that was how I did test

1 like

Then definitely ask GP for 25mcg dose increase in Levothyroxine and to test vitamin D, folate, ferritin and B12

Request coeliac blood test before changing to strictly gluten free diet. Try it for 6 months. If it helps stick on it

Watch out for change in brands of Levo. Always try to stick to same brand


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