Hi Winnie, I have been taking Nature Throid for about a year and feel much better. I now take 2 3/4 grains daily, all in one dose in the morning. Levo never did me any good either. Most people stop taking their Levo one day and then start the next day on 1 grain of NDT (equivalent to 36 mcg T4 and 9 mcg T3), divided into two doses. Stay on this dose for two weeks and then increase slowly, say, 1/4 to 1/2 grain weekly. Don't increase too quickly or you may get 'hyper' symptoms (sweats, palps, the 'runs' etc).
Other people reduce Levo and introduce NDT at the same time, so, lowering the Levo by half, taking half a grain of NDT and then reducing the Levo and increasing the NDT at the same time.
Everyone is different so what works for one might not be suitable for another.
Keep a record of what you are taking and what symptoms you experience.
These links will give you some more information on dosing:
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