This study possessed several strengths. The participants were deficient at baseline, the study duration was long and the dosage enabled the participants to reach optimal vitamin D status (40-60 ng/ml). The primary limitation of this study is that most of the participants were Caucasian, thereby decreasing the generalizability of their findings. Additionally, participant’s compliance decreased over time, a common challenge of long-term trials.
The researchers concluded,
“After taking account of the typical average 70% compliance observed in long-term trials of vitamin supplements for disease prevention, the results of the present study suggest that daily doses of 4000 IU of vitamin D3 may be required to achieve the high plasma levels of 25(OH)D associated with the lowest risks of mortality in the observational studies.”
Full article and source in:
vitamindcouncil.org/rct-sug...
To convert ng/ml to nmol/l multipy the ng/ml figure by 2.5.