Hashimotos Syndrome and Intestinal Gastritis

Another interesting review linking gastritis and Hashimoto's Syndrome, indicating absorption problems can accompany Hashimoto's quite frequently and interfere with T4 uptake. The paper is downloadable in Frontiers in Endocrinology:

MINI REVIEW ARTICLE

Front. Endocrinol., 26 April 2017 | doi.org/10.3389/fendo.2017....

Hashimoto’s Thyroiditis and Autoimmune Gastritis

Miriam Cellini, Maria Giulia Santaguida, Camilla Virili, Silvia Capriello, Nunzia Brusca, Lucilla Gargano and Marco Centanni*

6 Replies

oldestnewest
  • diogenes thank you for posting this article, but I am unable to open it at present and will try later. It just seemed to take a long time. While I have your attention could I please ask if I remember that you posted a paper on Diabetes levels being better if Thyroid was treated optimally. I felt sure that you posted something only a few weeks ago. I desperately have need of such information if you could lead me to any.

  • humanbean , thank you, that worked a treat.

  • I've extracted a paragraph from a paper by Patricia Wu in Clinical Diabetes 2000 which may be useful:

    How Thyroid Dysfunction May Affect Diabetic Patients

    The presence of thyroid dysfunction may affect diabetes control. Hyperthyroidism is typically associated with worsening glycemic control and increased insulin requirements. There is underlying increased hepatic gluconeogenesis, rapid gastrointestinal glucose absorption, and probably increased insulin resistance. Indeed, thyrotoxicosis may unmask latent diabetes.

    In practice, there are several implications for patients with both diabetes and hyperthyroidism. First, in hyperthyroid patients, the diagnosis of glucose intolerance needs to be considered cautiously, since the hyperglycemia may improve with treatment of thyrotoxicosis. Second, underlying hyperthyroidism should be considered in diabetic patients with unexplained worsening hyperglycemia. Third, in diabetic patients with hyperthyroidism, physicians need to anticipate possible deterioration in glycemic control and adjust treatment accordingly. Restoration of euthyroidism will lower blood glucose level.

    Although wide-ranging changes in carbohydrate metabolism are seen in hypothyroidism, clinical manifestation of these abnormalities is seldom conspicuous. However, the reduced rate of insulin degradation may lower the exogenous insulin requirement. The presence of hypoglycemia is uncommon in isolated thyroid hormone deficiency and should raise the possibility of hypopituitarism in a hypothyroid patient. More importantly, hypothyroidism is accompanied by a variety of abnormalities in plasma lipid metabolism, including elevated triglyceride and low-density lipoprotein (LDL) cholesterol concentrations. Even subclinical hypothyroidism can exacerbate the coexisting dyslipidemia commonly found in type 2 diabetes and further increase the risk of cardiovascular diseases. Adequate thyroxine replacement will reverse the lipid abnormalities.

    Note: the problems with hyperthyroidism will be mimicked to some extent by overdosing.

  • diogenes thank you so much for this information. Hopefully this might make GP surgery treat my son a little better for his low FT3 and stop keep complaining that his TSH is too low. He has Hypopituitarism with Septo-Optic Dysplasia and they can't seem to understand that a low, or even non-existent TSH is normal for him. In so bringing up his FT3 this might better treat his T2 diabetes and he might not need to have Insulin. I am grateful for this help.

  • Diogenes,

    It certainly explains why so many Hashi members have iron, B12, folate and vitD deficiencies.

You may also like...