This is a subject I personally haven’t heard about on this forum, yet I know gut issues are an important topic to the members of this group, and this is quite a nasty condition that I only recently learned about through diagnosis. Does anyone have any information on DAO deficiency (the enzyme needed to break down histamines in the gut) or Histamine Intolerance in general? Does anyone know how these conditions could be related to Hashimoto’s, or other thyroid/auto-immune conditions?
Here’s the little I’ve gathered since my diagnosis earlier this week: DAO (diamine oxidase) is an enzyme present in most people's intestinal tract. It is needed to break down Histamines that are present in foods, and in this process it keeps them from entering into your blood. When people don’t have this enzyme, or are intolerant to histamine for another reason these histamines cause all sorts of reactions similar to allergies, skin problems, rashes, intestinal issues, bloating, diarrhoea, constipation, weight loss, weight gain, and it can get to the point where full on anaphylactic shock occurs (happened to me several times in my life). Histamines are present in all foods pretty much, and as food degrades histamine levels start to skyrocket, so fermented foods and alcohol for example are incredibly high in histamines. Also as we know histamines play a role in inflammatory and auto-immune responses.
I’ve had stomach problems my entire life pretty much, and i’ve gone from doctor to doctor with little help, most just labeled me with IBS and told me to watch what I ate. I kept reacting to so many different foods nothing made sense, even things that are supposed to be healthy for me would send me into episodes that would last even 2 weeks at times where I would be so sick I thought I wouldn’t survive.
Apparently this conditions is very under-diagnosed, and people often go for many years before finally receiving diagnosis. I am convinced this is where my health problems started. I have Hashimoto’s (diagnosed March last year), and was diagnosed with Ulcerative Proctitis (colitis) and Duodenitis this week as well. I am 95% certain my gut problems came first, and I have a feeling that this DAO deficiency was the root of all problems. They don’t know what causes it, some say its genetic.
Please chime in with any advice / information / questions / comments you might have. I could use a lot of help here, and if this is something that isn’t spoken about on this forum, maybe it should be.