Another good osteoporosis article. We all agree that TSH alone is not a good indicator of thyroid levels, but high OR low levels of T3 and/or T4 do have an effect. Too much T3 can raise SHBG, which can negatively affect bone health. Too much T4, without T3, can also have a negative effect. And for women, lack of estrogen and progesterone may also have a negative impact, while testosterone is key for men. High cortisol levels or hydrocortisone treatment can also negatively affect bones. All hormones typically decline with age, which is why osteoporosis is usually seen in older people.