Hi Alfinno, I think low iron is implicated with swollen feet. Do you know your results for ferritin? From Stop the Thyroid Madness:
IRON RELATED (and you need all four, NOT just ferritin)
FERRITIN: Measures your levels of storage iron, which can be chronically low in hypothyroid patients. If your Ferritin result is less than 50, your levels are too low and can be causing problems…as well as leading you into anemia as you fall lower, which will give you symptoms similar to hypo, such as depression, achiness, fatigue. If you are lower than the 50’s, you are scooting by. Optimally, females shoot for 70-90 at the minimum (Janie’s is 80 when her iron is good); men tend to be slightly above 100. If your ferritin is much higher, you have INFLAMMATION–the latter causes iron to be thrust into storage and inflammation is common with thyroid patients for a variety of reasons. In less common cases, higher ferritin can be from liver disease, alcoholism, diabetes, asthma, or some types of cancer. If ferritin is high along with a high % Sat and Serum iron, you may have hemachromatosis or a MTHFR defect. Having heavy metals can push your ferritin low, by the way, while your other iron labs are good or higher. We learned that we should be off all iron for at least 12 hours before testing to see what supplementation is doing for us, but 5 days to see your true iron levels.
SERUM IRON (also called just Iron or Total iron): Measures the small amount of your circulating iron which is bound by the transferrin. You are looking for ‘close to’ 110 for women, upper 130’s for men, based on what we’ve seen on hundreds of lab results. European or Australian lab ranges are something like this 7-27, and optimal is in the lower-to-mid 20s at the least for women and higher for men. If you are considerably higher than optimal, you could have the MTHFR mutation which will need testing and treatment. The MTHFR mutation also drives the ferritin low with normal or high iron. If all four iron labs are high (serum iron, % saturation, TIBC and ferritin, you may have the genetic hemochromatosis and you can ask your doctor for testing for that.
PERCENT % SATURATION of IRON: Measures your serum iron divided by your TIBC. Women want to be close to 35% (or .35 for Canadian ranges), we have discovered, and men go from 38% to 40-45%. Like all iron labs, you should be off all iron for at least 12 hours before testing to see how your supplementation is doing, or up to 5 days to see what your natural levels are. The latter may be best. NOTE: % Saturation can look falsely good or high if your TIBC is too low!!
TIBC (Total iron binding capacity): measures whether a protein called transferrin, produced by the liver, is enough to carry iron in the blood. Used to determine anemia or low body iron. If your result is high in the range and in the absence of chronic disease, you may be anemic. With healthy amounts of iron, this test will be low in the range—about 1/4th above the bottom number in the range provided.