Sorry for delay …. this question is one I have pondered myself as read contradicting articles on the presence of selenium decreasing TGAb (but UK sun dictates sunbathing whilst reading romance as opposed to thyroid antibody contemplation//investigations ! ! .. … ;o))) .. ) …
We know our thyroid glands (like to) retain high levels of selenium concentrations to aid iodination but also and importantly to neutralise oxidative damage caused by the thyroid peroxidase enzyme which oxidases iodide ions to form iodine.
In low selenium, free radicals can damage the thyroid cells and so attract infiltrating lymphocytes in thyroid tissue, producing inflammation and further destruction to the thyroid gland (Hashi attack).
Therefore, supplementing selenium neutralises the excess hydrogen peroxide, calming the reactive immune response and lowering antibodies. Marz posted a Suzie Cohen link on reactive oxidative damage caused by excessive H2O2 in the thyroid gland the other day.
TPOAbs & TGAbs don't directly attack thyroid tissue but cause a signalling to the immune system to attack. Isabella Wentz (her with the beautiful smiley face) explains in her book how in a study on mice …[ … Selenium reduced TGAb tiers and increased the number of circulating T reg cells that help the immune system recognise itself and prevent the lymphocytic infiltration of the thyroid … ] … Therefore, we can conclude that supplementing Selenium in those who are deficient, can decrease TGAb.
There is much data on selenium having several modifying effects on the immune system and loads of the effect on TPOAbs but apart from a mention in Izabella’s book, I have not found creditable data regarding a TGAb reduction and so (as only a fellow Hashi sufferer) conclude that supplementing selenium does decrease TGAb but maybe more as a secondary action as reducing any elevated antibodies (such as TPOAb) must be beneficial in the whole of the thyroid health.… but who knows ? ? … What are your thoughts on this ? ? ….. Do you have any data ? ? …
On a side note …. amongst these selenoproteins is the glutathione peroxidase which also neutralises the hydrogen peroxide and is made from glutathione and selenium. I recently chelated after mercury removal (amalgam) and don't have the glutathione gene (a major handicap).
Mercury is a major thyroid disrupting chemical but selenium (& glutathione) protect the thyroid by binding to mercury and making it completely inert. I supplement loads of antioxidants as preventing oxidative damage keeps us BEAUTIFUL ! ! ! .. … ;o))))) …. .. Rock the antioxidants ! ! ! … ... :o)) … & selenium.