The following gives a detailed account/explanation of how Roche devised their lab ranges (which look very familiar...).
I'm assuming (possibly wrongly) that this is what has been adopted in the UK?
Unless I've misunderstood, there seems to be contradictory information given under the TSH section with regard to comparison with lab ranges in other parts of Europe. For instance, there is a statement:
"The so determined reference ranges correspond to those obtained in 2000 in a multicenter reference value study done in Spain with Elecsys TSH: 0.57 μIU/mL (0.48–0.68 μIU/mL) to 3.65 μIU/mL (3.41–3.90 μIU/mL) 95% central range (0.90 confidence interval of the 2.5% and 97.5% quantiles), n = 168."
However, they have determined their range to be 0.27 μIU/mL - 4.2 μIU/mL.
An upper limit of 4.2 is very different from 3.65.
Does anyone has the brainpower, time and energy (all of which I'm lacking at the moment) to have a more detailed look at the document and provide some cogent interpretation? It also covers FT3, FT4. T3, T4, TBC, anti-TPO, anti-Tg and Tg lab values and at 52 pages, it's quite a hefty document.