Thyroid UK
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Alternating b12 & b complex

Hello ive just started taking my jarrows b12 and a b complex I was taking them together but found I felt a bit awful so now I'm taking b12 one day and b complex the next does that sound like it will work ok? I'm also taking spatone every morning too been just over a week but I'm feeling a bit more cheerful and sleeping much better I actually go too bed at 9pm now before was more like 11pm - 12pm. The constant noise in my ears is less 😆 and my menstrual cycle was 29 days I have pcos and this is the first short cycle id had the lowest before was 32 but average 36-42 days long so wow can it really All be due too b12?

Thanks too everyone for advice on this you peeps give gave me the knowledge my gp didn't have 👌

11 Replies

Hi shaws super fast reply my pcos unfortunately doesn't seem too improve with thyroxine been hypo for three years now but before diagnosis I had scan due too pain frm c section showed my right ovary large and cystic and left normal size no cysts. With Endo thinking I wasn't hypo recently and my meds going down I started spot bleeding and had another scan right ovary still enlarged and cystic left ovary normal no cysts and ive had other scans before and after miscarriage all the same thing. Not sure why not plus I cant sem too lose weight on thyroxine Endo says it gives an increased appetite. So I'm fluffed


You may not be on sufficient levothyroxine. I don't know where your Endo gets his idea that it gives you an increased appetite.

What are your recent blood test results for your thyroid hormones, with the ranges. If you don't have a copy post them on a new question for comments. Endos and doctors are quite happy if the patient's results are 'in range'.

I'm glad your suppementing with B12 and B complex they will be very helpful.


FYI My endo also assumed my appetite had increased as she thinks I'm over medicated looking at tsh and t4 results. In reality I prob eat less as often too tired to eat!


I do not think they are aware that weight gain is a clinical symptom of hypothyroidism. I think the reason is that they are so into the blood test results rather than listening to the patient.

Do you have a copy of your blood test results, with the ranges? Ask surgery for a copy - and we are entitled to our results but some surgeries charge a nominal sum for paper/ink. Mine gives them free.

Re PCOS - I don't have the link but this is a copy:-

Multiple Ovarian Cysts as

a Major Symptom of Hypothyroidism

The case I describe below is of importance to women with polycystic ovaries. If they have evidence, such as a high TSH, that conventional clinicians accept as evidence

of hypothyroidism, they may fair well. But the TSH is not a valid gauge of a woman's tissue thyroid status. Because of this, she may fair best by adopting self-directed

care. At any rate, for women with ovarian cysts, this case is one of extreme importance.

In 2008, doctors at the gynecology department in Gunma, Japan reported the case of a 21-year-old women with primary hypothyroidism. Her doctor referred her to the

gynecology department because she had abdominal pain and her abdomen was distended up to the level of her navel.

At the gynecology clinic she underwent an abdominal ultrasound and CT scan. These imaging procedures showed multiple cysts on both her right and her left ovary.

The woman's cholesterol level and liver function were increased. She also had a high level of the muscle enzyme (creatine phosphokinase) that's often high in hypothyroidism. Blood testing also showed that the woman had primary hypothyroidism from autoimmune


It is noteworthy that the young woman's ovarian cysts completely disappeared soon after she began thyroid hormone therapy. Other researchers have reported girls with primary hypothyroidism whose main health problems were ovarian cysts or precocious puberty. But this appears to be the first case in which a young adult female had

ovarian cysts that resulted from autoimmune-induced hypothyroidism.

The researchers cautioned clinicians: "To avoid inadvertent surgery to remove an ovarian tumor, it is essential that a patient with multiple ovarian cysts and hypothyroidism

be properly managed, as the simple replacement of a thyroid hormone could resolve the ovarian cysts."[1]


1. Kubota, K., Itho, M., Kishi, H., et al.: Primary hypothyroidism presenting asmultiple ovarian cysts in an adult woman: a case report. Gynecol. Endocrinol., "

So get a copy of your blood test results with the ranges and post them on a new question for more comments on them.

Sometimes we have to learn more than the Endos.

This is an excerpt from the archived website:-

Our treatment team uses the TSH level only initially to help clarify a patient’s thyroid status. But during treatment, we completely ignore the level. The reason is that the TSH level is totally irrelevant to normalizing the patient’s whole body metabolism and relieving his or her suffering. The only clinical value of the TSH level is to see the effect of a particular dose of thyroid hormone on the pituitary gland’s "thyrotroph" (TSH-secreting) cells.

The thyrotroph cells are vastly more sensitive to thyroid hormone than are other body cells. Some endocrinologists argue that we know the ratio of two sensitivities: that is, the ratio of the sensitivity of the pituitary to a dose of thyroid hormone to the sensitivity of other tissues to that dose. From knowledge of that ratio, they argue, we can use the TSH to gauge the thyroid hormone dose that properly regulates the metabolism of all body cells.

The problem is that for individual patients, we don’t know that ratio. These endocrinologists fail to realize that statistical inferences from large groups of patients do not tell us specifically enough what we need to know clinically about individual patients.

Because the pituitary is far more sensitive than other tissues to thyroid hormone—and just how much more sensitive in individual patients, we do not know!—we can’t reliably deduce the effects of a particular dose of thyroid hormone on most body cells from the effect of that dose on the pituitary thyrotroph cells.

The near impossibility of this deduction being valid is made clear by many studies in the field of thyroid hormone resistance. The studies show that in many patients, various tissues differ in how sensitively they respond to a particular dose of thyroid hormone. That is, not all tissues respond to the same dose of thyroid hormone with the same vigor. Hence, from an individual patient’s TSH level, we can reliably validly deduce nothing about the effects of a thyroid hormone dose on tissue cells other than the pituitary thyrotrophs.

Gynecol. Endocrinol.,


I duplicated a response above but have erased it and put in the one I was meaning too.


The question is, nettiboo, do you feel better taking them on alternate days? It sounds rather odd to me, I can't see why taking them together would make you feel bad, and taking them apart wouldn't. But, whatever works for you! As long as you manage to raise your B12 levels, it doesn't matter how you take them. :)

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Taking 5000mcg of B12 made me feel sickly so I now split the dose across the day.

I am convinced it is very effective for our symptoms.

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Hi Nettiboo1982

Do you know already that it is very, very important to have the B vitamins in the correct balance? If you have too much of the wrong ones, that can effectively deplete the others, and some supplements short-change the expensive ones.

I'm wondering if you were perhaps taking too much at once (they are water-soluble so excess is excreted and may cause very yellow wee).

I go for yeast flakes which should have the correct balance, and I think yeast extract does too, both being foods which I believe is better than taking supplements, but I have noticed these are advertising 'extra B12' recently which is not good.

Should say here, I'm no vitamin expert and others may know much better, but the above is what I have read and I seek out sources of information that are not promoting supplements.


I too alternate B12and b Complex - don't think it odd as it is recommended that b vits. shouldn't be taken in isolation. I use spray B12 and liquid B complex The B complex contains the same amount of B12...And is cheaper. Think one gets the best of both worlds by alternating ? I feel well and energetic on my "regime". if you can be bothered let me know how you get on. - Thanks


I have tinnitus , tell me , how much B12 do you take in one Day. Thanks, david


I have tinnitus, could you tell me how much B12 you take a day. Thanks David


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