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Cinnamon intake reduces serum T3 level and modulates tissue-specific expression of thyroid hormone receptor and target genes in rats

There have previously been mentions of cinnamon - Grey Goose even posted about it something like six months ago. This abstract should be taken with a pinch of salt as there is insufficient information. Maybe care during the wassailing season ahead?

(Sorry cinnamon_girl - nothing personal. :-) )

J Sci Food Agric. 2015 Sep 16. doi: 10.1002/jsfa.7460. [Epub ahead of print]

Cinnamon intake reduces serum T3 level and modulates tissue-specific expression of thyroid hormone receptor and target genes in rats.

Gaique TG1, Lopes BP2, Souza LL2, Paula GS2, Pazos-Moura CC2, Oliveira KJ1.

Author information

1Departamento de Fisiologia e Farmacologia, Universidade Federal Fluminense, 24210-130, RJ, Brazil.

2Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, 21949-900, RJ, Brazil.



Cinnamon has several effects on energy metabolism. However, no data exist on the impact of cinnamon intake on thyroid hormone serum concentrations and action, since thyroid hormones (TH) play a major role in metabolism.


Male rats were treated with cinnamon water extract (400 mg kg-1 body weight, 25 days). Cinnamon supplementation resulted in a lower serum total T3 level accompanied by normal serum T4 and TSH levels. The cinnamon-treated rats did not exhibit significant differences in TSHβ subunit, TRβ or deiodinase type 2 mRNA expression in the pituitary. In the liver, cinnamon did not change the TRβ protein expression or the deiodinase type 1 mRNA expression, suggesting that there were no changes in T3 signaling or metabolism in this organ. However, mitochondrial GPDH, a target gene for T3 in the liver, exhibited no changes in mRNA expression, although its activity level was reduced by cinnamon. In the cardiac ventricle, T3 action was markedly reduced by cinnamon, as demonstrated by the lower TRα mRNA and protein levels, reduced SERCA2a and RyR2 and increased phospholamban mRNA expression.


This study has revealed that TH action is a novel target of cinnamon, demonstrating impairment of T3 signaling in the cardiac ventricles.

This article is protected by copyright. All rights reserved.


Cinnamomum zeylanicum; cardiac ventricle; liver; rats; thyroid hormone; thyroid hormone nuclear receptors



[PubMed - as supplied by publisher]

2 Replies

Think I might give up the cinnamon on my porridge of a morning! Suppose I should give up the brown sugar as well though.

1 like

Might be useful for someone with slight hyperthyroidism who doesn't want to take Carbimazole?


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