Any research or evidence on how cortisol interr... - Thyroid UK

Thyroid UK

141,244 members166,489 posts

Any research or evidence on how cortisol interrupts t3 take up?

sulamaye profile image
10 Replies

Hi, I know from being on here lots that low or high cortisol effects t3 take up in the cells and low t3 can also effect cortisol production, but is there any evidence, research or anything I could use to validate this point of view when I see an endo next week?

Written by
sulamaye profile image
sulamaye
To view profiles and participate in discussions please or .
Read more about...
10 Replies
sulamaye profile image
sulamaye

I mean that validates the close interrelationship of these two hormones?

mischa profile image
mischa

I too would like to know. If anyone could throw some light on the interaction between cortisol and T3 it would be very much appreciated.

cc120 profile image
cc120

Some discussion on this on: healthunlocked.com/thyroidu...

sulamaye profile image
sulamaye

Thanks the discussion reiterates what I've heard here but as it started with an endo saying he couldn't understand why the t3 wasn't getting into cells despite knowing the patient had high cortisol emphasises to me that what is needed is a credible source that an NHS endo will be forced to consider. What I want to know is what is the source of these ideas, are there any credible research papers? 😊

humanbean profile image
humanbean

It may not answer your question, but I thought it was tangentially related and interesting.

Apparently, high cortisol damps down production of TRH and TSH. So someone with high cortisol and hypothyroid symptoms may be more hypothyroid than the TSH would suggest. Sadly this is just an abstract, but it does list references too :

link.springer.com/article/1...

sulamaye profile image
sulamaye in reply tohumanbean

Thanks I'll take a look - the abstract is fine, I can't see an endo reading more can you? Ha ha

sulamaye profile image
sulamaye in reply tohumanbean

this was in the references: onlinelibrary.wiley.com/doi...

something to do with cortisol and t3 interaction, again only the abstract. Thanks for the lead

humanbean profile image
humanbean in reply tosulamaye

Are you more interested in high cortisol or low cortisol?

press.endocrine.org/doi/abs...

I also found this - looks interesting but your endo may consider the source to be dodgy - A Review Of Natural And Neutraceutical Therapies For Clinical Practice :

pointinstitute.org/wp-conte...

It does have some pretty pictures, and has loads of references. :)

mmimedicine.com/assets/pdf/...

I'm finding more interesting papers by referring to hypercortisolism and hypocortisolism in my searches, rather than "high cortisol" and "low cortisol". I'm also trying to search for these terms in connection with "triiodothyronine" rather than T3. But what I'm mostly getting back is loads of stuff about Cushing's and Addison's. Bah!

sulamaye profile image
sulamaye in reply tohumanbean

Thank you! I have low cortisol, but I am extrapolating that any cortisol interaction with T3 indicates the two have a significant relationship to one another.

sulamaye profile image
sulamaye in reply tohumanbean

the last one is interesting because it relates to m.e/cfs (which I have) too an dis more easily readable. What I really want is something that shows that low cortisol will interupt t3 take up, meaning you need to take cortisol in order to get T3 into the cells. Hard to process some of this stuff when so ill! thank you for your help.

Not what you're looking for?

You may also like...

Low and high cortisol levels! What's the best time to take T3?

Hi for past few weeks I have been dosing with 75mcg levo and 5mcg T3. Take at morning time. My...
DizzyD profile image

Is t4 absolutely necessary to take when on t3?

Why do Drs insist on taking T4 along with t3? Is it really necessary for the body? I have been...
Everdean profile image

Any comment on cortisol/aldosterone results please

Hi all, I've just received my results of a private blood test from Inuvi. Could anyone comment as...
PotatoFan profile image

Normal to feel bad when starting small dose of T3? Advice on testing cortisol and RT3.

Hi, I am thinking of getting my cortisol and RT3 levels tested. I have just started taking 5mcg T3...
Emily78 profile image

How much T3 should I take?

Hello, I have finally received my T3 which I ordered online as cannot get where I live and would...
Bristol1965 profile image

Moderation team

See all
PurpleNails profile image
PurpleNailsAdministrator
SlowDragon profile image
SlowDragonAdministrator
Jaydee1507 profile image
Jaydee1507Administrator

Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.

Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.