Cytomel

[jmuelchi]

I received a package today of Cytomel. Three boxes, 30 75mcg gel capsules each. Having been on 150mcg of Levothyroxine a day for over 10 years, can anyone tell me the correct way to take this new medication and how to reduce the Levo?

[polly3]

Is that the slow release tryotex(?) ?

[jmuelchi in reply to polly3]

Don't know, all printing is in Mexican and I can only make out some of the words. Don't know the wording for slow release

[helvella Administrator Thyroid UK in reply to jmuelchi]

Help us to help you!

Does it say Triyotex on the boxes? Can you see the maker's name PRODUCTOS MEDIX, SA de CV ?

[jmuelchi in reply to helvella]

Hi ,

Yes the name on the box is Triyotex and makers name is PRODUCTS MEDIX, S.A. de C.V.

[helvella Administrator Thyroid UK in reply to jmuelchi]

Basic information is here:

medicamentos.com.mx/DocHTM/...

Translation by Google below. Be very careful - this translation is definitely not perfect.

TRIYOTEX * (Liothyronine)

CAPSULES

Synthetic thyroid hormone

PRODUCTS MEDIX, SA de CV.

- And dosage form

- INDICATIONS

- Pharmacokinetics in Humans

- Contraindications

- PRECAUTIONS

- PRECAUTIONS AND RESTRICTIONS OF USE DURING PREGNANCY AND LACTATION

- Adverse Reactions

- DRUG INTERACTIONS AND OTHER GENDER

- ALTERATIONS OF LABORATORY TESTS

- PRECAUTIONS IN RELATION TO EFFECTS OF Carcinogenesis, Mutagenesis, Impairment of Fertility

- DOSAGE AND ADMINISTRATION

- Overdosage; REPRESENTATIONS AND MANAGEMENT (antidotes)

- PRESENTATION

- RECOMMENDATIONS FOR STORAGE

- LEGENDS OF PROTECTION

And dosage form :

Each capsule contains:

Liothyronine equivalent to 75 m g ...........

liothyronine

Excipient. ................................ 1 capsule

INDICATIONS :

q TRIYOTEX * is indicated as a supplement to the activity of the natural thyroid hormone, hypothyroidism, euthyroid goiter, hyperthyroidism, myxedema, cretinism, thyroid aplasia, thyroiditis and after surgery of the thyroid gland.

q TRIYOTEX * contains liothyronine, a synthetic form of the hormone T 3, which can be used in patients allergic to thyroid hormone or thyroid extracts dried pork or beef.

Pharmacokinetics in Humans : Although the exact mechanism of action is unknown, it is known that thyroid hormones increase the metabolism of organic tissues, noticed by increases in the following parameters: oxygen consumption, respiratory rate, body temperature, cardiac output , heart rate, blood volume, increased metabolism of fats, carbohydrates and proteins, and activation of the enzyme system on the growth and maturation. It is also an important factor in CNS development.

Liothyronine is 4 times more potent than thyroxine (T 4) and a shorter half-life. Liothyronine is almost completely absorbed from the gastrointestinal tract (95%), binds almost 99% bound to plasma proteins (thyroglobulin), with an average half-life of 1-2 days euthyroid patients.

CONTRAINDICATIONS :

q Coexisting adrenal disease.

q Hypersensitivity to salt.

q Acute myocardial infarction.

q Thyrotoxicosis.

PRECAUTIONS : Use with caution in patients in whom the functional integrity of the cardiovascular system is not assured.

In the event that is necessary to administer this type of preparation in elderly patients, suggests low-dose therapy is started and you adjust according to patient response.

The use of such preparations in patients with diabetes mellitus or diabetes insipidus and adrenal insufficiency may aggravate the intensity of their symptoms, so it is suggested dosage adjustment of the antidiabetic or replacement therapy for adrenal insufficiency.

Patients with hypothyroidism are particularly sensitive to treatment with such preparations. It is suggested initiating therapy with low doses in these patients.

In some rare cases, administration of thyroid hormones may precipitate a state of hyperthyroidism or hypothyroidism may aggravate preexisting.

You can see a little hair loss in children who are receiving this therapy, although this effect is reversible and disappear even with continued drug administration.

The persistence of a clinical or laboratory hypothyroidism despite adequate medical therapy may be indicative of a poor drug absorption, excessive fecal loss, no patient cooperation or lack of drug activity. Cellular resistance to thyroid hormones is extremely rare.

PRECAUTIONS AND RESTRICTIONS OF USE DURING PREGNANCY AND LACTATION : Because thyroid hormones do not cross the placental barrier and proven by clinical experience, no adverse effects on the fetus is not expected to pregnant women when thyroid hormones are administered. Therefore, it is not recommended to discontinue treatment with this salt if the woman becomes pregnant.

Small amounts of thyroid hormones in lactating women receiving thyroid hormone supplement, without having associated them with no major side effects.

However, caution is advised when TRIYOTEX * a lactating women.

ADVERSE REACTIONS : Adverse reactions are rare if proper treatment regimen is followed. Generally, side reactions that occur are the result of an overdose or a very rapid increase in administration. If this occurs, it is suggested decrease or discontinuation of TRIYOTEX *. Signs that the dosage is exceeded are: palpitations, tachycardia, arrhythmia, angina pectoris boxes, tremor, headache, nervousness, insomnia, changes in appetite (hiporexia or hyperorexia), nausea, diarrhea or gastric intolerance and very rarely, weight loss, menstrual irregularities, sweating, heat intolerance and fever.

DRUG INTERACTIONS : Thyroid hormones appear to increase the catabolism of vitamin K which may increase the effects of warfarin and dicoumarol, so it is suggested to adjust the dose of anticoagulants to start managing TRIYOTEX *. There seems necessary correction if anticoagulant therapy in patients stabilized starts.

In diabetic patients, administration of TRIYOTEX * can lead to increased needs insulin or oral hypoglycemic, so close monitoring suggested in these patients.

The therapeutic effectiveness of digitalis may be affected when administered TRIYOTEX *, which can lead to congestive heart failure or arrhythmia, due to which a close eye on these patients is suggested.

Concomitant use of tricyclic antidepressants and thyroid hormones can increase the pharmacological effect of both preparations.

In patients receiving low thyroid replacement therapy with estrogen therapy, there may be an increase in free thyroid hormone, estrogen because decrease the blood levels of thyroid hormone transport protein.

Cholestyramine binds the liothyronine in the intestine, which may affect the absorption rate. Suggested spaced 4 or 5 hours making both drugs.

Ketamine can cause hypertension and tachycardia in patients on thyroid therapy.

ALTERATIONS OF LABORATORY TESTS : In interpreting the results of laboratory tests to determine thyroid function should take into account factors that affect levels of thyroxine transport protein, such as pregnancy, infectious hepatitis, estrogens and oral contraceptives with estrogen.

Also, you can see these levels decreased in patients with nephrosis, acromegaly, and after androgen replacement therapy or corticosteroids.

A diet rich in iodine can interfere with iodine uptake test, producing a decrease in uptake which can be misinterpreted as a decreased thyroid function.

PRECAUTIONS IN RELATION TO EFFECTS OF Carcinogenesis, Mutagenesis, Impairment of Fertility : In animal studies there are no data to suggest any of these effects using TRIYOTEX *.

DOSAGE AND ADMINISTRATION : The dosage of such preparations should be adjusted individually, so it is suggested to start with low doses and irlas increasing every 7-14 days to obtain the desired therapeutic effect. In most cases, the maintenance dose is 75 m g per 24 hours, ie * TRIYOTEX capsule every 24 hours orally.

Overdosage; REPRESENTATIONS AND MANAGEMENT (antidotes) : A chronic overdosage can lead to a state of pseudohipertiroidismo manifested headache, irritability, nervousness, sweating, tachycardia, bloating, menstrual irregularities and emaciation. Can be induced venous congestive heart failure or angina pectoris boxes, and even get to shock. A massive overdose can lead to a syndrome semeje a thyroid storm.

It is suggested to reduce the dose or temporarily discontinue therapy. By restoring treatment should be initiated at low doses and increasing irlas to the desired response. Usually the hypothalamus-pituitary-thyroid axis is normalized between 6 and 8 weeks after the suppression of overdose.

An acute overdose should be followed by immediate treatment that includes the following: general supportive measures (vital signs, airway, renal function) and intensive monitoring of possible frequent sympathomimetic effects such salts.

Efforts should be decreased drug absorption, either forcing vomiting and if this is not possible, place a nasogastric tube and make gastric lavage. Where is this heart failure, administer digitalis. Generally, sympathomimetic effects adequately respond to the administration of propranolol (a receptor blocker b 2).

Steps must be taken to control fever, hypoglycemia and possible loss of fluids. Should not be excluded the possibility of an asymptomatic adrenal insufficiency.

PRESENTATION : Box with 30 capsules in bubble pack.

RECOMMENDED STORAGE : Store in cool, dry place.

LEGENDS OF PROTECTION : Exclusively for medical literature. Keep out of reach of children. Its sale requires a prescription.

Made in Mexico by:

PRODUCTS MEDIX, SA de CV.

* Registered trademark

[Clutter]

Jmuelchi, 75mcg T3 is equivalent to 225mcg Levothyroxine. I don't see how you can break down the gel capsule to the 6.25mcg T3 dose advised when starting T3 to see how you acclimate. You really need 25mcg tablets which can be quartered. The Mexican pharmacies won't have 25mcg tablets before end of April.

[vanillanice in reply to Clutter]

The capsule contains tiny beads so some people are breaking them open and counting the balls. 20 beads = standard 4mcg T3 dose.

[Clutter in reply to vanillanice]

Vanillanice, interesting, thank you. Is the slow release mechanism changed by taking x amount of beads as a dose?

[vanillanice in reply to Clutter]

I think you would have to experiment with it and measure your pulse and temperatures (and other hypo symptoms) to know what it's doing. T3 is hard to manufacture properly and it seems most people don't do as well on slow release type. The slow release T3 is dependent on the conditions of the person's digestive system... in some cases it might release all at once, or not at all. I don't think there is a reason to take slow release unless you can't get anything else.

[page0345 in reply to Clutter]

hello, I am new here and can' figure out how to order from Mexico?

[Clutter in reply to page0345]

Welcome to the forum, Page0345.

Mexican Cynomel won't be available until November. You can post a question giving a little background information about yourself ie whether you have a diagnosis and how much Levothyroxine you are taking, and ask members to send you a private message where to source T3.

[helvella Administrator Thyroid UK]

Few people here have experience of Triyotex - maybe worth looking at old posts such as:

healthunlocked.com/thyroidu...

Please be very, very careful. Ordinary liothyronine, if you take a little too much, should only last a few hours. Slow-release can keep on going for many more hours. So however tempting it might be, raise whatever dose extremely slowly and carefully.

I'd have though that 75 micrograms was a huge dose of liothyronine to start on. It has been mentioned that you might be able to divide the contents but I don't know.

[susia]

YOU should stop levothyroxine altogether, wait 10 days without taking any drug, and then begin T3 on a very low dosage, that should be gradually and steadily increased. Levothyroxine might be used once again in very rare occasions, only if strictly and urgently needed.