I've just come across the following article which appeared in the Nutrients Journal (Netherlands) on 16 Feb:
Here is the abstract:
'The concept is emerging that low-normal thyroid function, i.e., either higher
thyroid-stimulating hormone or lower free thyroxine levels within the euthyroid reference
range, could contribute to the development of atherosclerotic cardiovascular disease. It is
possible that adverse effects of low-normal thyroid function on cardiovascular outcome may
be particularly relevant for specific populations, such as younger people and subjects with
high cardiovascular risk. Low-normal thyroid function probably relates to modest increases
in plasma total cholesterol, low density lipoprotein cholesterol, triglycerides and insulin
resistance, but effects on high density lipoprotein (HDL) cholesterol and non-alcoholic fatty
liver disease are inconsistent. Low-normal thyroid function may enhance plasma cholesteryl
ester transfer, and contribute to an impaired ability of HDL to inhibit oxidative modification
of LDL, reflecting pro-atherogenic alterations in lipoprotein metabolism and HDL function,
respectively. Low-normal thyroid function also confers lower levels of bilirubin, a strong
natural anti-oxidant. Remarkably, all these effects of low-normal thyroid functional status
appear to be more outspoken in the context of chronic hyperglycemia and/or insulin
resistance. Collectively, these data support the concept that low-normal thyroid function may
adversely affect several processes which conceivably contribute to the pathogenesis of
atherosclerotic cardiovascular disease, beyond effects on conventional lipoprotein measures.'
The wording is somewhat circumpect ('could contribute'; 'may be ... relevant'; 'Probably relates to', etc., but there are some interesting concepts here.
Is there anyone with the knowledge/expertise who could decipher it for us mere mortals? And also state if it is a document we could present to GPs/endos? In other words, is there enough scientific evidence, given the hesitant stance of the abstract?
NB the 'About us' page of the Journal's website opens with the following sentence: 'Nutrients (ISSN 2072-6643) is an international, peer-reviewed open access advanced forum for studies related to Human Nutrition' , so it has 'proper' status, as it were.