Ito et al (2017) Biochemical Markers Reflecting Thyroid Function in Athyreotic Patients on Levothyroxine Monotherapy
, Thyroid , Vol 7 No.4
Conclusions: The serum biochemical markers of thyroid function in patients on levothyroxine monotherapy (LT4) following total thyroidectomy suggest that the patients with mildly suppressed TSH levels were closest to euthyroid, whereas those with normal TSH levels were mildly hypothyroid and those with strongly suppressed TSH levels were mildly hyperthyroid.
Methods: A total of 133 consecutive euthyroid patients with papillary thyroid carcinoma who underwent a total thyroidectomy were prospectively studied. The patients’ serum levels of lipoproteins, sex hormone-binding globulin, and bone metabolic markers measured preoperatively were compared with the levels measured at postoperative LT4 therapy 12 months after the thyroidectomy.
Results: The postoperative serum sex hormone-binding globulin (p<0.001) and bone alkaline phosphatase ( p < 0.01) levels were significantly increased in the patients with strongly suppressed TSH levels (£0.03 lIU/mL). The postoperative serum low-density lipoprotein cholesterol levels were significantly increased ( p < 0.05), and the serum tartrate-resistant acid phosphatase-5b levels were significantly decreased ( p < 0.05) in the patients with normal TSH (0.3 < TSH £5 lIU/mL). In the patients with mildly suppressed TSH (0.03 < TSH £0.3 lIU/mL) and fT3 levels equivalent to their preoperative levels, all metabolic markers remained equivalent to their preoperative levels.