Hi, I am confused by the reverse T3 debate. I realise that the reality is that so far we don't actually know as much about it as would be useful, but I have two questions.
1. Does anyone know how long Rt3 lasts in the body, does it die of its own accord the way T4 and T3 will or does it simply block receptors indefinitely?
2. Unless your problem is a conversion issue why does going T3 only resolve the problem shouldn't it be the other way round? What I understand is the RT3 is a mechanism to prevent too high a take up of T3, a safety mechanism by the pituitary gland to ensure hyper symptoms are limited as much as possible. Therefore the pituitary senses too much T3 and converts T4s into RT3 for the very purpose of lowering take up. This can obviously go wrong. I suspect that I have been on too much T3 to T4 ratio for 13 years, resulting in too much RT3 being made and blocking my body's normal function.
If that hypothesis were the case (and it's not because for some reason I am converting T4 to RT3 for no good reason) - why would taking no T4, and going only T3 be the solution? I have read posts by people saying they do this - ( and I'm leaving to one side the people who thrive on solely T3 indefinitely, perhaps because they simply can't convert or aren't producing T3) - and feel great for 4-8 weeks but then have to go back to combo as things don't feel right. They interpret this as having cleared out the RT3, leaving their body needing both T4 and T3. This doesn't make sense to me, surely if RT3 is made by sensing too much T3 the solution is to cut T3 for a time to allow the body to stop making RT3 and get itself back in balance before adding increasing amounts of T3 back to find the right spot?
Since unless your thyroid has been removed or completely stopped functioning your body will still be making some T4, if you swamp the body with T3 you are potentially going to get it making the T4 it does make into RT3 as a reaction? So slowly - because obviously as a hypo person you don't make loads - the body will build up RT3 from the T4 it is making. Initially this may lead to a drop in T4 because there isn't so much of it to convert, but it will not stop the body from thinking like a toxic body that wants to make as much RT3 as possible in order to block take up of T3.
On the other hand if you cut all T3 for a while the pituitary has no reason to convert the T4 you are taking into RT3, it can gradually lower the levels of RT3 that have built up as it senses there is a need for T3 conversion to take place. Then when it has got itself back in balance you will need to start adding very very small amounts of T3 to find your body's balance that is getting enough T3 into your cells, but isn't swamping the body with T3 triggering a RT3 reaction.
As with all these things I suspect we are all different and our bodies will each need its own unique combo balance. However, I can not see the logic of swamping the body with T3 as a way of preventing RT3, you are still putting your body in an unnaturally hyper alert state. I suspect my body has been given too much T3 and that this has caused my rise a rise in RT3 leading to me being very ill over time, triggered by massive stress events to the body.
If anybody knows what we actually do have evidence for about RT3 I would be really interested to hear it, as I am really trying to get to grips with what has happened to me and the best way to solve it.