Thyroid UK
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How to tell if thyroid resistant or "pooling"

Hi Everyone,

I am trying to figure out what the heck is going on and why I am unresponsive to HIGH dose T3 (270 mcg). I take it as one dose daily and am still VERY hypo in symptoms including myxedema which is the main concern.

Some sites/resources state that if one is "pooling" - meaning that the T3 is NOT getting into the cells due to low ferretin or low/high cortisol - then the free T3 in the blood will show very high and that the Reverse T3 may or may not be high aswell. However, if I am to look at the work of Dr Lowe who dosed his patients accordingly, he expected to see a very high free T3 due to the high dosing and his theory was that these patients were thyroid resistant obviously because a dose this high does not cause them hyperstimulation while it would affect others without resistance.

That said, as far as symptoms go....some say that if the T3 is "pooling" then people feel hyper, other sites that the patient continues to have hypo symptoms.

So, my question is in the world do I know if I am "pooling" the T3 and it is not getting in or if it is not getting in because my dose still is not high enough.

Any help would be much appreciated. In the meantime, I am still looking for possible causes of the resistance.


2 Replies

Hi Suzzanai, thanks for posting. I'm sorry you've had no replies.


hi we are the same i'm on 230 t3 and it helps considerably but i find i crash in the afternoon look like the living dead i have no hyper symptoms at all in fact i could take a higher dose of t3 but a little scared. i must be t3 resistant i have no idea what i can do about it either, all i know is i need t3 but how much? my endo with go nuts when he sees my bloods

free throxine <2 (11.00-23.00)

TSH 0.02 (0.3-5.5)

FREE T3 12.4 (4.1-7.9


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