Why do so many people here when they try T3 start on such high doses then wonder why it doesn't make them feel better? Surely the best starting point is to copy nature with a dose of 5-10ug T3 with enough T4 to maintain the TSH around 0.5-2. And if that doesn't work THEN try other combinations. If people start on 20ug T3 or more then this might make them feel just as bad as T4 only and they conclude that T3 does not work for them when it simply may be that they are on too much T3. Why don't people start with the most common sense option first?
My personal experience is that I felt good on 10ug T3 plus 125ug T4 with a TSH of 0.5. But did not feel good on 20ug T3 plus 75ug T4 and a similar TSH. And my blood results reflected that (T3 top of the range and T4 bottom of the range). I also tried out different doses of T4 along with the 20ug T3 ranging from 125ug to 50ug and didn't feel better on any (TSH ranged from 0.05 to 7 depending on the dose of T4). I've currently stopped the T3 completely and am trying out T4 only to see how that compares. Will continue to post updates of my experimenting incase it is useful to others. My current opinion is that I felt worst on 20ug T3, that 10ug T3 was better than no T3 and that keeping the TSH between 0.5 and 2 is the most important thing to feel best.