VITAMIN D STATUS IN AUTOIMMUNE
Sunil Kota, MD1
, Lalit Meher2
, Sruti Jammula, PhD3
1. Medwin Hospital, 2. MKCG medical College, 3.
Roland Institute of Pharmacutical Sciences
Objective: To investigate vitamin D status in patients with
Methods: The study group consisted of 100 patients with
newly diagnosed Hashimato’s thyroiditis and 100 subjects
as the control group. Parameters of calcium metabolism,
thyroid function tests and 25(OH) vitamin D levels were
Results: Mean age of the study study groups was 33.4
± 4.8 years with female: male= 72: 28. Vitamin D
insufficiency/ deficiency ( 25 (OH) D < 30 ng/ml) rate was
significantly higher in the Hashimoto’s group compared
with the control subjects (75 % vs 20%, p<0.0001). In
the Hashimoto group, mean 25(OH) vitamin D levels
were significantly lower compared with the control group
(12.5±7.0 vs 22.3±7.9 ng/mL, p<0.001). The study group
revealed higher Anti TPO levels in patients vitamin
D deficiency 25 (OH) D < 20 ng/ml than patients with
vitamin D insufficiency group (25 (OH) D < 30 ng/ml)
[650.4 ± 35.4 IU/ml vs 340.3 ± 65.4 IU/ml, p, 0.001].
Serum vitamin D level was inversely correlated with the
Anti TPO levels (r = - 0.30, p = 0.007).
Discussion: Vitamin D is involved in immune system and,
in particular, on T cell-medicated immunity. Vitamin D
receptor is profoundly present in the immature immune
cells of thymus and the CD8. Low vitamin D level gives
rise to a variety of autoimmune disorders including type 1
Conclusion: The higher vitamin D deficiency rates besides
lower vitamin D levels in the Hashimoto group together
with the inverse correlation between vitamin D and
AntiTPO suggest that vitamin D deficiency may have a
role in the autoimmune process in Hashimato’s thyroiditis.
I have included the whole piece although there is an awful lot of it.