I was just wondering if anyone has any experience and/or knowledge of dealing with receptor resistance? I am currently crushing T3 and dissolving in water and drinking it during the day in order to try get some much needed thyroid hormone into my cells. I have managed to build up to 3/4 of a 25mcg tablet and also take 4 nutri adrenals as instructed by Dr Peatfield. This is the first time I have taken any thyroid hormone as was diagnosed with ME by the NHS. Although I still need to spend many hrs resting, I have seen some improvement and had some brighter days and even managed to leave the house on a couple of occasions and see a friend which is fantastic but the brighter times are diminishing fast and Im actually starting to feel like the severe fatigue and pain amongst other things is really starting to kick in again. Dr P has told me to play around with it but to increase slowly and when I'm feeling brave to try some in tablet form. I know we are all different but I just wondered if anyone had been in a similar situation and what they experienced and how long it took before receptors came online again?