Experiences with

Vedolizumab

I am currently on vedolizumab but unfortunately after 3 years it has stopped working. I am currently in a very nasty flare and have to choose which biologic I would prefer to try next, Infliximab or a new drug called upadacitinib.

I was diagnosed difficult to control astgma in 2018. My asthma had been unsteady over the last couple of years with frequent hospital admissions. 3 within 1 year. I have now been put on to nucala (mepolizumab injections). Does this now mean I have severe asthma.

I recently changed from Mepolizumab monthly dose after 8 months and started on Dupilumab twice month.The results have been noticable by myself and others. I have far more energy now. Still coughing a little though, but I can live with this if my energy had improved. It's still early days as I have

My consultant at the hospital suggested I have this type of asthma. Apparently your white blood cells attack your lungs. I was put on a one year study and I’m now permanently on the injection once a month. In the US the brand name is Nucala, here it’s Mepolizumab.

Hi, I have eosinophilic asthma & so far I have had 6 injections of mep, first 4 I felt great, came off the steriods my breathing was much better and much less coughing & had energy to be able to do things, however, these last couple of months, I've had continuous body pains, especially the tops of

Hi everyone. I have Eosinophils Asthma and take Mepolizumab injection plus use a couple of steroid inhalers. I am please to say that my asthma is well under control and I am able to exercise. Prior to the asthma I successfully used ibuprofen to help with inflammation. This now "conflicts" with

Hi, could anyone advise re these injections please. I've had 2 so far & the last couple of weeks my bowels have been hay wire, very bad wind & also leakages. They have certainly helped my asthma but wondered if these side effects settle down. I was ok after the 1st one but this 2nd one has had a

Well beautiful people, this is an update on my journey with Dupilumab. Second visit this morning to the hospital for my third dose. They gave me two doses on my first visit which is the initial loading dose. I injected myself this morning as it comes in a pre-filled pen and had to wait just ½ hour this

I was diagnosed with eosinophilic asthma in 2017. I had rhinitis and nasal polyps prior to being diagnosed - I was 45 when I was diagnosed. Unfortunately despite having mepolizumab, benralizumab and omalizumab I have had little relief - eosinophils and FeNo remain high. To have a normal (ish) life

Anyone using vedolizumab how is it going? Any info! Once my issues calm moving onto this drug any info appreciated. Have read Nice report and drug info.

So, ive been discussed at MDT again... as i reacted to benralizumab then was switched to mepolizumab again reacted within 5 mins... respiratory team have now said i cant have any interleukin (IL)-5–eosinophil pathway treatment, including mepolizumab and reslizumab that target IL-5 itself, and benralizumab

Has anyone been on this . and has it worked how quickly does it work , and can I go on holiday to a hot country. Bit worried they want me have to infusion before I go, is there anyone that can give a bit of advice on this please . Thankyou

hey so after 2 stat doses of first biologics I had to go back to mdt to be discussed as was reacting within minutes each time and requiring close monitoring for 4hrs both times. So today started mepo within 5 mins same but not quite so severe I feel rubbish. They've now added benralizumab to my list

Hi everyone I have been successfully controlled by Mepo for just over 4 years. However just recently it has stopped working as effectively. I am being reviewed by my consultant. Has this happened to anyone else and if so what drug have they replaced this with? Many thanks, Corinne 😁🙏

Hi there, my 16 year old son is just about to start Mepolizumab. His consultant and respiratory nurses are amazing and have been great at talking us through this but just wondered if some of you who are on Mepo or have been had any words of wisdom/advice/support to share. My son has had issues with his

Has anyone else experienced severe lower back pain on Vedolizumab?? I’m just wanting to make sure it’s normal sometimes it feels so stiff that I can’t move

I was diagnosed with eosiniphilic asthma a few years ago - the asthma came in my 40's - breathing problems and nasal polyps. Two years of back and two to the GP saw me referred to a specialist. I was given mepolizumab - sadly it did not have the hoped for results. I was switched to fasenra which showed

Has anyone been on the Vedolizumab injections? I started them 3 weeks ago and each time I have to inject myself it hurts like a b*tch. I have the adulimimab ones before and they just stung a little but these ones are really sore and causing my skin to bruise and lump.

Can anyone who is currently on Mepolizumab or Benralizumab who are self-administering help? My wife is on Benra and has to attend the local hospital every other month to be handed the self injection pen by a nurse to administer the dose herself. She has asked repeatedly if the ‘pens’ could be sent to

The research found that people treated with infliximab had significantly lower concentrations of antibodies, when compared to 428 people on an alternative treatment, vedolizumab. https://www.exeter.ac.uk/news/research/title_855647_en.html BMJ Journals, Gut.