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A Conversation with Dr Tam about Zanubrutinib: A Novel BTK Inhibitor
Zanubrutinib has fewer off-target effects on related enzymes, including the epidermal growth factor receptor (EGFR), interleukin 2–inducible T-cell kinase (ITK), Janus kinase 3 (JAK3), human epidermal growth factor receptor 2 (HER2), and
tyrosine
kinase expressed in hematopoietic carcinoma (TEC).
Zanubrutinib has fewer off-target effects on related enzymes, including the epidermal growth factor receptor (EGFR), interleukin 2–inducible T-cell kinase (ITK), Janus kinase 3 (JAK3), human epidermal growth factor receptor 2 (HER2), and
tyrosine
kinase expressed in hematopoietic carcinoma (TEC).
Jm954
Administrator
in
CLL Support
5 years ago
Nobel Prize - William Kaelin, Peter Ratcliffe, and Gregg Semenza.
Neutralizing monoclonal antibodies against VEGF and small molecule
tyrosine
kinase inhibitors targeting VEGFRs have been shown to block its angiogenic activity, resulting in tumor vascular regression, anti-tumor effects and improvements in patient survival.
Neutralizing monoclonal antibodies against VEGF and small molecule
tyrosine
kinase inhibitors targeting VEGFRs have been shown to block its angiogenic activity, resulting in tumor vascular regression, anti-tumor effects and improvements in patient survival.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Need help with a petition to have Tirosint available in UK!
I know tirosint is easily obtainable in the USA, Canada and Mexico. I had discussed with other members; who would like to figure out on tirosint’s availability in the UK. There are a few million in my country, the US, getting it prescribed now. I wonder if this is something that If enough people could
I know tirosint is easily obtainable in the USA, Canada and Mexico. I had discussed with other members; who would like to figure out on tirosint’s availability in the UK. There are a few million in my country, the US, getting it prescribed now. I wonder if this is something that If enough people could
Hidden
in
Thyroid UK
4 years ago
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Thumbs up for Nilotinib - Phase II Trials
Nilotinib is a brain-penetrant
tyrosine
kinase inhibitor that may alter brain dopamine metabolism. Method: A phase II randomized, double-blind, placebo-controlled evaluation of the impact of Nilotinib on safety, tolerability and clinical effects in PD.
Nilotinib is a brain-penetrant
tyrosine
kinase inhibitor that may alter brain dopamine metabolism. Method: A phase II randomized, double-blind, placebo-controlled evaluation of the impact of Nilotinib on safety, tolerability and clinical effects in PD.
FMundo
in
Cure Parkinson's
5 years ago
PROSEEK: A Phase 2 Study In Early Parkinson's Disease Patients Evaluating The Safety And Efficacy Of Abl Tyrosine Kinase Inhibition Using K0
https://clinicaltrials.gov/ct2/show/NCT03655236
https://clinicaltrials.gov/ct2/show/NCT03655236
Farooqji
in
Cure Parkinson's
5 years ago
Allergic reaction to thyroid meds
My daughter has tried np and levo Both gave her itchy,swollen throat which I know is an allergic reaction to something Now the doc wants her to try tirosint Does anyone else have the same reaction to meds Or could it be something different
My daughter has tried np and levo Both gave her itchy,swollen throat which I know is an allergic reaction to something Now the doc wants her to try tirosint Does anyone else have the same reaction to meds Or could it be something different
Itileguy
in
Thyroid UK
5 years ago
Approved Treatments for Triple Negative MBC Patients
If a US patient’s cancer has a Neurotrophic Receptor
Tyrosine
Kinase (NTRK) gene fusion without a known acquired resistance mutation, and if there has been progression on prior therapy with no satisfactory treatment options, Larotrectinib (Vitrakvi) - an oral
tyrosine
kinase inhibitor that acts as an
If a US patient’s cancer has a Neurotrophic Receptor
Tyrosine
Kinase (NTRK) gene fusion without a known acquired resistance mutation, and if there has been progression on prior therapy with no satisfactory treatment options, Larotrectinib (Vitrakvi) - an oral
tyrosine
kinase inhibitor that acts as an
Bestbird
in
SHARE Metastatic Breast Cancer
5 years ago
cytomel side effects
Anyone experience acid reflux from cytomel ? Been on 5mcg added to Tirosint 50mcg and have had terrible heart burn. It isn't on the list of sides, doc said he hasn't heard of this. Probably due to something else ...
Anyone experience acid reflux from cytomel ? Been on 5mcg added to Tirosint 50mcg and have had terrible heart burn. It isn't on the list of sides, doc said he hasn't heard of this. Probably due to something else ...
abartme
in
Thyroid UK
5 years ago
Hashimoto's - med decrease and feeling awful
Hi, I am 35yo female with Hashimoto’s thyroiditis. I got labs done last week and my doc said I'm border line hyper. I think I most definitely am b/c I was STARVING every 45 minutes and eating constantly. I ended up gaining weight and I just wasn’t feeling good about myself. My lab results were: TSH
Hi, I am 35yo female with Hashimoto’s thyroiditis. I got labs done last week and my doc said I'm border line hyper. I think I most definitely am b/c I was STARVING every 45 minutes and eating constantly. I ended up gaining weight and I just wasn’t feeling good about myself. My lab results were: TSH
Fmljkl
in
Thyroid UK
5 years ago
Approved Therapies for Triple Positive (HR+, HER2+) MBC Patients
If a US patient’s cancer has a Neurotrophic Receptor
Tyrosine
Kinase (NTRK) gene fusion without a known acquired resistance mutation, and if there has been progression on prior therapy with no satisfactory treatment options, Larotrectinib (Vitrakvi) - an oral
tyrosine
kinase inhibitor that acts as an
If a US patient’s cancer has a Neurotrophic Receptor
Tyrosine
Kinase (NTRK) gene fusion without a known acquired resistance mutation, and if there has been progression on prior therapy with no satisfactory treatment options, Larotrectinib (Vitrakvi) - an oral
tyrosine
kinase inhibitor that acts as an
Bestbird
in
SHARE Metastatic Breast Cancer
5 years ago
FDA-Approved Treatments for HER2+, Hormone Receptor Negative Patients
If your cancer has a Neurotrophic Receptor
Tyrosine
Kinase (NTRK) gene fusion without a known acquired resistance mutation, and if you’ve progressed on prior therapy and have no satisfactory treatment options, Larotrectinib (Vitrakvi) - an oral
tyrosine
kinase inhibitor that acts as an "on" or "off"
If your cancer has a Neurotrophic Receptor
Tyrosine
Kinase (NTRK) gene fusion without a known acquired resistance mutation, and if you’ve progressed on prior therapy and have no satisfactory treatment options, Larotrectinib (Vitrakvi) - an oral
tyrosine
kinase inhibitor that acts as an "on" or "off"
Bestbird
in
SHARE Metastatic Breast Cancer
5 years ago
CRPC & 'Drug Repositioning'
lenalidomide has significantly improved overall survival in myeloma (which formerly carried a poor prognosis), although toxicity remains an issue for users.[2] It costs $163,381 per year for the average patient." [6a] [6b] Pazopanib "(trade name Votrient) is a potent and selective multi-targeted receptor
tyrosine
lenalidomide has significantly improved overall survival in myeloma (which formerly carried a poor prognosis), although toxicity remains an issue for users.[2] It costs $163,381 per year for the average patient." [6a] [6b] Pazopanib "(trade name Votrient) is a potent and selective multi-targeted receptor
tyrosine
pjoshea13
in
Advanced Prostate Cancer
5 years ago
FDA-Approved Treatments for HR+, HER2- Premenopausal Patients
If your cancer has a Neurotrophic Receptor
Tyrosine
Kinase (NTRK) gene fusion without a known acquired resistance mutation, and if you’ve progressed on prior therapy and have no satisfactory treatment options, Larotrectinib (Vitrakvi) - an oral
tyrosine
kinase inhibitor that acts as an "on" or "off"
If your cancer has a Neurotrophic Receptor
Tyrosine
Kinase (NTRK) gene fusion without a known acquired resistance mutation, and if you’ve progressed on prior therapy and have no satisfactory treatment options, Larotrectinib (Vitrakvi) - an oral
tyrosine
kinase inhibitor that acts as an "on" or "off"
Bestbird
in
SHARE Metastatic Breast Cancer
5 years ago
Fat-soluble B1, for a 25x enhancement at the brain ?
Note: A commercial presentation of L-
Tyrosine
by Country Life makes no mention of vitamin B1: « L-
Tyrosine
is an amino acid that supports the production of brain neurotransmitters dopamine and norepinephrine. Country Life uses vitamin B6 in order to aid in utilization.»
Note: A commercial presentation of L-
Tyrosine
by Country Life makes no mention of vitamin B1: « L-
Tyrosine
is an amino acid that supports the production of brain neurotransmitters dopamine and norepinephrine. Country Life uses vitamin B6 in order to aid in utilization.»
Pa-zzi69
in
Cure Parkinson's
5 years ago
Approved Treatment Options for HR+, HER2- Postmenopausal Women
If a US patient’s cancer has a Neurotrophic Receptor
Tyrosine
Kinase (NTRK) gene fusion without a known acquired resistance mutation, and if there has been progression on prior therapy with no satisfactory treatment options, Larotrectinib (Vitrakvi) - an oral
tyrosine
kinase inhibitor that acts as an
If a US patient’s cancer has a Neurotrophic Receptor
Tyrosine
Kinase (NTRK) gene fusion without a known acquired resistance mutation, and if there has been progression on prior therapy with no satisfactory treatment options, Larotrectinib (Vitrakvi) - an oral
tyrosine
kinase inhibitor that acts as an
Bestbird
in
SHARE Metastatic Breast Cancer
5 years ago
Advice on most complete lab tests to do, including possible Vitamin deficiencies, for Hypothyroidism after radiation therapy
Hi to all, I have found various lists of labs to be done, one that seemed comprehensive I couldn't download, and would be thankful if someone could spell it out for me again (my memory is not too good...!) I am currently on Tirosint, since May, and it's proving difficult to manage. (I can give more info
Hi to all, I have found various lists of labs to be done, one that seemed comprehensive I couldn't download, and would be thankful if someone could spell it out for me again (my memory is not too good...!) I am currently on Tirosint, since May, and it's proving difficult to manage. (I can give more info
Koola
in
Thyroid UK
5 years ago
Mucuna 40% -100% LDOPA? B1 regimen - thoughts?
I also experience a ton of nausea which I can combat with 1/4 tsp powdered L-
Tyrosine
and that works great as a precursor. I experience so much gas, belching and sometimes projectile vomit that I’m unsure of what I’m doing wrong.
I also experience a ton of nausea which I can combat with 1/4 tsp powdered L-
Tyrosine
and that works great as a precursor. I experience so much gas, belching and sometimes projectile vomit that I’m unsure of what I’m doing wrong.
MissRita
in
Cure Parkinson's
5 years ago
Transcriptional profiling reveals a potent activity ofanticancer imidazoacridinone C-1311 against prostatecancer cells
Anticancer imidazoarcidinone C-1311 (Symadex™) is a new inhibitor of topisomerase II and receptor
tyrosine
kinase FLT3 that has been tested in phase II studies against metastatic breast cancer.
Anticancer imidazoarcidinone C-1311 (Symadex™) is a new inhibitor of topisomerase II and receptor
tyrosine
kinase FLT3 that has been tested in phase II studies against metastatic breast cancer.
puxi
in
Advanced Prostate Cancer
5 years ago
Tirosint
Can you get tirosint on prescription in the UK?
Can you get tirosint on prescription in the UK?
kingyl
in
Thyroid UK
5 years ago
Tirosint and cytomel over ndt
So I'm not doing well on compound ndt here in Canada, even though my bloods are close to being optimal. I've gained so much weight this past few months it crazy. My naturopath is considering changing my to tirosint and cytomel. Im due to return to the UK at the end of the year and I'm wondering if
So I'm not doing well on compound ndt here in Canada, even though my bloods are close to being optimal. I've gained so much weight this past few months it crazy. My naturopath is considering changing my to tirosint and cytomel. Im due to return to the UK at the end of the year and I'm wondering if
kingyl
in
Thyroid UK
5 years ago
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