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Thyrotropin alfa
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Reply to queries on paper by Bianco et al
This is a reply to a group querying the validity of Bianco et al's paper on T4/T3 prefrence by some patients. I thought it nteresting to read the various arguments so I put it in full here, as it's behind a paywall. Response to Letter to the Editor From Bonnema et al: “Comparative Effectiveness of Levothyroxine
This is a reply to a group querying the validity of Bianco et al's paper on T4/T3 prefrence by some patients. I thought it nteresting to read the various arguments so I put it in full here, as it's behind a paywall. Response to Letter to the Editor From Bonnema et al: “Comparative Effectiveness of Levothyroxine
diogenes
in
Thyroid UK
2 years ago
Combination T4/t3 therapy discussed
I can't remember if I've already posted this, but if not here the paper is - available,
Current Medical Research and Opinion
Volume 37, 2021 - Issue 12
Endocrinology
Triiodothyronine alongside levothyroxine in the management of hypothyroidism?
Ulrike Gottwald-Hostalek
I can't remember if I've already posted this, but if not here the paper is - available,
Current Medical Research and Opinion
Volume 37, 2021 - Issue 12
Endocrinology
Triiodothyronine alongside levothyroxine in the management of hypothyroidism?
Ulrike Gottwald-Hostalek
diogenes
in
Thyroid UK
3 years ago
Subclinical hypothyroidism and patient response
This paper shows that SCH can be accompanied by sleep problems amogst other things. Wu et al. BMC Endocrine Disorders (2021) 21:112 https://doi.org/10.1186/s12902-021-00772-
Lifestyle is associated with thyroid function in subclinical hypothyroidism: a cross-sectional study
Kejun
This paper shows that SCH can be accompanied by sleep problems amogst other things. Wu et al. BMC Endocrine Disorders (2021) 21:112 https://doi.org/10.1186/s12902-021-00772-
Lifestyle is associated with thyroid function in subclinical hypothyroidism: a cross-sectional study
Kejun
diogenes
in
Thyroid UK
3 years ago
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A Longitudinal Study of Medial Temporal Lobe Volumes in Graves Disease
I hope some who have had Grave's read this and add some comments. [i]
A Longitudinal Study of Medial Temporal Lobe Volumes in Graves Disease
Mats Holmberg, Helge Malmgren, Rolf A Heckemann, Birgitta Johansson, Niklas Klasson, Erik Olsson, Simon Skau, Göran Starck, Helena Filipsson Nyström The
I hope some who have had Grave's read this and add some comments. [i]
A Longitudinal Study of Medial Temporal Lobe Volumes in Graves Disease
Mats Holmberg, Helge Malmgren, Rolf A Heckemann, Birgitta Johansson, Niklas Klasson, Erik Olsson, Simon Skau, Göran Starck, Helena Filipsson Nyström The
helvella
Thyroid UK
in
Thyroid UK
3 years ago
Reference Levels for TSH in Iodine-Sufficient Low-Risk Pregnant Women
Just don't be different! If TSH levels are, as stated, population specific because of differences in ethnicity, then we need a rather more significant changes than just making the top of the TSH reference interval a bit higher. I think it easy to imagine a clinic in the north of India. They pick up
Just don't be different! If TSH levels are, as stated, population specific because of differences in ethnicity, then we need a rather more significant changes than just making the top of the TSH reference interval a bit higher. I think it easy to imagine a clinic in the north of India. They pick up
helvella
Thyroid UK
in
Thyroid UK
3 years ago
Our letter on SCH
This published letter is our take on SCH. Given in full as behind a paywall Letter to the Editor EJE
Treatment options for subclinical hypothyroidism
Rudolf Hoermann1 , John E M Midgley2 , Rolf Larisch 1 and Johannes W Dietrich3,4
1 Department for Nuclear Medicine, Klinikum Lüdenscheid
This published letter is our take on SCH. Given in full as behind a paywall Letter to the Editor EJE
Treatment options for subclinical hypothyroidism
Rudolf Hoermann1 , John E M Midgley2 , Rolf Larisch 1 and Johannes W Dietrich3,4
1 Department for Nuclear Medicine, Klinikum Lüdenscheid
diogenes
in
Thyroid UK
3 years ago
Glimpses of understanding
This recent paper does begin to tackle the problems of therapy with T4 only. It is a start in that it does recognise patients who need combination therapy and that past trials were inadequate to study this. Plus the prospect of a more controlled T3
dosing regimen. It's behind a paywall. However I
This recent paper does begin to tackle the problems of therapy with T4 only. It is a start in that it does recognise patients who need combination therapy and that past trials were inadequate to study this. Plus the prospect of a more controlled T3
dosing regimen. It's behind a paywall. However I
diogenes
in
Thyroid UK
3 years ago
Paper discussing TSH as a moving target with age which affects its diagnostic significance
This paper discusses how TSH values can change within-person and the effect on diagnosis using TSH as the preferred diagnostic test.
REVIEW article
Front. Endocrinol., 24 February 2021
https://doi.org/10.3389/fendo.2021.619568
Within-Person Variation in Serum Thyrotropin Concentrations
This paper discusses how TSH values can change within-person and the effect on diagnosis using TSH as the preferred diagnostic test.
REVIEW article
Front. Endocrinol., 24 February 2021
https://doi.org/10.3389/fendo.2021.619568
Within-Person Variation in Serum Thyrotropin Concentrations
diogenes
in
Thyroid UK
3 years ago
Slowly but slowly they are catching up
This new paper discusses the power of FT4 testing against TSH and finds FT4 better. That's at least a small step forward in that it challenges TSH-is-all thinking in therapy. The authors haven't yet caught up as regards using FT3 measurement as well, but even a small step forward is good. Hennessey is
This new paper discusses the power of FT4 testing against TSH and finds FT4 better. That's at least a small step forward in that it challenges TSH-is-all thinking in therapy. The authors haven't yet caught up as regards using FT3 measurement as well, but even a small step forward is good. Hennessey is
diogenes
in
Thyroid UK
3 years ago
Papers questioning TSH as a diagnostic keep coming
A new Australian paper which examines the value of TSH testing and its relationship to best hypothyroidism detection. Don't agree with all of it, but the concept that FT4/3 measurements are better than TSH is well covered.
Endocrine
https://doi.org/10.1007/s12020-021-02851-6
Thyroid
A new Australian paper which examines the value of TSH testing and its relationship to best hypothyroidism detection. Don't agree with all of it, but the concept that FT4/3 measurements are better than TSH is well covered.
Endocrine
https://doi.org/10.1007/s12020-021-02851-6
Thyroid
diogenes
in
Thyroid UK
3 years ago
Paper showing which thyroid hormone assays are sensitive to biotin
This new paper is behind a paywall, but the abstract says all that is needed. It identifies those test manufacturers whose methods use biotin which disturbs thyroid function tests amongst others. This gives TUK posters/admin some ammunition to challenge incorrectand misleading results a) by not taking
This new paper is behind a paywall, but the abstract says all that is needed. It identifies those test manufacturers whose methods use biotin which disturbs thyroid function tests amongst others. This gives TUK posters/admin some ammunition to challenge incorrectand misleading results a) by not taking
diogenes
in
Thyroid UK
3 years ago
Greater Understanding of PV, ET Drives Potential New Treatment Options
“Continued high-impact research may soon foster the development of disease-modifying therapies for PV and ET and satisfy this need for the optimal management of patients with these MPNs,” they said. Researchers are also determining how to best optimize current treatment options, including JAK inhibitors
“Continued high-impact research may soon foster the development of disease-modifying therapies for PV and ET and satisfy this need for the optimal management of patients with these MPNs,” they said. Researchers are also determining how to best optimize current treatment options, including JAK inhibitors
Manouche
in
MPN Voice
3 years ago
THE 2021 EUROPEAN GROUP ON GRAVES' ORBITOPATHY (EUGOGO) CLINICAL PRACTICE GUIDELINES FOR THE MEDICAL MANAGEMENT OF GRAVES' ORBITOPATHY
Despite brexit, this group includes the UK and has two members located in UK hospitals. [i]Eur J Endocrinol . 2021 Jul 1;EJE-21-0479.R1. doi: 10.1530/EJE-21-0479. Online ahead of print.
THE 2021 EUROPEAN GROUP ON GRAVES' ORBITOPATHY (EUGOGO) CLINICAL PRACTICE GUIDELINES FOR THE MEDICAL MANAGEMENT
Despite brexit, this group includes the UK and has two members located in UK hospitals. [i]Eur J Endocrinol . 2021 Jul 1;EJE-21-0479.R1. doi: 10.1530/EJE-21-0479. Online ahead of print.
THE 2021 EUROPEAN GROUP ON GRAVES' ORBITOPATHY (EUGOGO) CLINICAL PRACTICE GUIDELINES FOR THE MEDICAL MANAGEMENT
helvella
Thyroid UK
in
Thyroid UK
3 years ago
Roxadustat and thyroid-stimulating hormone suppression
• thyroxine • free triiodothyronine • darbepoetin
alfa
Issue Section: EXCEPTIONAL CASES [/i] Full paper freely accessible here: https://academic.oup.com/ckj/article/14/5/1472/6104625
• thyroxine • free triiodothyronine • darbepoetin
alfa
Issue Section: EXCEPTIONAL CASES [/i] Full paper freely accessible here: https://academic.oup.com/ckj/article/14/5/1472/6104625
helvella
Thyroid UK
in
Thyroid UK
3 years ago
Skipping thyroid dose makes me feel better
I've been on thyroxine for more than 15 years and always has problems with tiredness and mood. Recently I realised that the days where I felt great over the last few months (and probably for years but I didn't notice the pattern) was when I accidentally skipped my thyroxine dose. And I mean really great
I've been on thyroxine for more than 15 years and always has problems with tiredness and mood. Recently I realised that the days where I felt great over the last few months (and probably for years but I didn't notice the pattern) was when I accidentally skipped my thyroxine dose. And I mean really great
CraftyAsparagus
in
Thyroid UK
3 years ago
Help with interpretation of my new blood work
Hi all I have Hashimoto's and recently been put on old formulation Euthyrox after years on NDTs, as my conversion problem has improved after I starting supplementing with selenium. Ten weeks ago, I was on 125 ug Euthryox per day and these were my results: S-TSH 0.09 uIU/mL L 0.35 - 4.94 S-FT3 3.5 pmol
Hi all I have Hashimoto's and recently been put on old formulation Euthyrox after years on NDTs, as my conversion problem has improved after I starting supplementing with selenium. Ten weeks ago, I was on 125 ug Euthryox per day and these were my results: S-TSH 0.09 uIU/mL L 0.35 - 4.94 S-FT3 3.5 pmol
whynotwhynot
in
Thyroid UK
3 years ago
A rare mutation of thyroid hormone receptor beta gene in thyroid hormone resistance syndrome
Another thyroid hormone receptor genetic mutation which results in Resistance to thyroid hormone (RTH). [i]
A rare mutation of thyroid hormone receptor beta gene in thyroid hormone resistance syndrome in Endocrinology, Diabetes & Metabolism Case Reports
DOI: https://doi.org/10.1530/EDM-21-0023
Another thyroid hormone receptor genetic mutation which results in Resistance to thyroid hormone (RTH). [i]
A rare mutation of thyroid hormone receptor beta gene in thyroid hormone resistance syndrome in Endocrinology, Diabetes & Metabolism Case Reports
DOI: https://doi.org/10.1530/EDM-21-0023
helvella
Thyroid UK
in
Thyroid UK
3 years ago
Why thyroid function tests are in such a mess!
This is an excerpt from an Italian scientist replying to me on the reasons why the various tests are not properly controlled by the companies selling them: He describes the way the various groups don't communicate with each other and therefor have no interest in getting the tests harmonised:
Basing
This is an excerpt from an Italian scientist replying to me on the reasons why the various tests are not properly controlled by the companies selling them: He describes the way the various groups don't communicate with each other and therefor have no interest in getting the tests harmonised:
Basing
diogenes
in
Thyroid UK
4 years ago
TSH variability
This new paper (open) describes how variable is TSH in individuals and discusses the implication on using this for diagnosis.
REVIEW ARTICLE
Front. Endocrinol., 24 February 2021
https://doi.org/10.3389/fendo.2021.619568
Within-Person Variation in Serum Thyrotropin Concentrations:
This new paper (open) describes how variable is TSH in individuals and discusses the implication on using this for diagnosis.
REVIEW ARTICLE
Front. Endocrinol., 24 February 2021
https://doi.org/10.3389/fendo.2021.619568
Within-Person Variation in Serum Thyrotropin Concentrations:
diogenes
in
Thyroid UK
4 years ago
Do not use TSH in a simple manner when making a diagnosis or examining treatment
This provisionally accepted paper discusses the need for individual assessment of patients in TSH measurements - not just taking "within range" as an acceptable diagnosis. It will be accessible when fully published.
Front. Endocrinol. | doi: 10.3389/fendo.2021.619568
Within-person variation
This provisionally accepted paper discusses the need for individual assessment of patients in TSH measurements - not just taking "within range" as an acceptable diagnosis. It will be accessible when fully published.
Front. Endocrinol. | doi: 10.3389/fendo.2021.619568
Within-person variation
diogenes
in
Thyroid UK
4 years ago
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