Experiences with

Thyrotropin alfa

Saw this on drugshortagescanada and thought it was interesting.... The sole manufacturer of Pegasys® API, Roche Diagnostics GmbH produced a final batch of peginterferon alfa-2a in 2017. Establishment of new API manufacturer for peginterferon alfa-2a, Loba biotech GmbH, Fischamend, Austria (affiliate

Hi everybody, I'm Ciaran & I have been very recently diagnosed Polycythaemia Vera. As you're probably aware, the early stages of research are quite daunting &, whilst my haematologist is recommending Hydroxycarbamide or Peginterferon alfa 2a to rapidly reduce my platelet count & get my high stats under

   “Our results suggest that a higher initiating-dose regimen, with the flexibility of dose schedule adjustment from biweekly to monthly, i.e., once every 3-5 weeks, after the CHR is stabilized with 1 year of ropeg treatment is associated with a high chance of neoplastic cell clearance and robust clinical

Last line of the conclusion: [i]"Early identification and treatment of hypothyroidism can prevent prolonged patient distress, ensure timely management, and improve overall quality of life."[/i] [i]Cureus. 2025 Jan; 17(1): e77814.[/i] [i]Published online 2025 Jan 22. https://doi.org/10.7759

Thyroid Hormone Homeostasis in Levothyroxine-treated Patients: Findings From ELSA-Brasil I’ve only just read some of this paper. I think there are some important points: I do not think they considered any possible conversion by the thyroid but only original production of T3. I do not think

A topic which has been discussed numerous times. One of the big problems is that the difference between someone who lives in a well-heated house and someone else who has little heating and spends much time outside is dramatic. This could reduce or enhance the effects reported. Nevertheless, it

I was diagnosed in 2012 with Hashi's Hypothyroidism and struggled for over a decade to get an Endo who would work with my persistent low FT3. Unfortunately, my (sharp young bright female) Endo who understood that a low TSH is normal with combination therapy has moved away. I have been given to new young

An interesting paper in many ways. The association of TRab with Alopecia Areata; The understanding of the issues of TRab and Graves - stimulating and others; The sex differences discussed; And the establishment of a closer-than-ever link between thyroid and Alopecia Areata including recommendations

A potentially important issue for some people. And one that is 100% ignored when dentists say we should not rinse after brushing. Even if we do rinse after some time, it is likely that we will swallow some of the calcium ingredients (if our toothpaste contains any). Despite being written as a paediatric

Discussion; The results in our study demonstrate that the new dosing regimen of 250-350-500 µg of ropeginterferon alfa-2b is well-tolerated and highly efficacious in patients suffering from PV. This dosing regimen was associated with a rapid achievement of CHR without the need for phlebotomy or erythrocyte

If you search this forum, you can find 52 posts which mention "cataract" - and several gave rise to significant discussions. Search if you wish: https://healthunlocked.com/thyroiduk/search/posts?query=cataract I'm not sure how much "proof" this paper provides of a link. But it certainly points a finger

Like most documents, this has strengths and weaknesses. You might find it easier to follow than some. Though some of it really is quite hard for those not already familiar with thyroid issues. Or more up-to-date (it was published this year - 2024). And it might provide some useful and quotable

A rather disappointing paper. First, the full paper is, as so often, behind a paywall. Also, because the the paper doesn't come out with a clear "Yes, the tests are wonderful and reliable." It is quite clear that there is sufficient uncertainty to question all results from these tests. We have had

For the last 60 years I have been a vigilant weight watcher, daily exerciser and have watched my calorie intake. When I commenced treatment for my Essential Thrombocytosis in January 2021, my weight was 53.5kg. Three years later this has ballooned to 60.3kg, despite my efforts to control any

Hi just after some help please. I have had suppressed TSH levels since 2010, apart from a blip in 2014 when it was 2 pmol/l. (range is 0.35 to 4.7. ). My level has been consistently low at 0.02 pmol/l from 2018 to 2024. My T4 has been in range over the years ( 7.8 to 21) however my T3 was raised at

Conclusions: High long-term response rates (80.4% at 24 months; 73.2% at 72 months) were achieved with ropeginterferon alfa-2b treatment in the low-risk PV population when the dose was optimized on an individual basis. No specific baseline characteristics among low-risk PV patients appear to be associated

Hola! I'm new to this group and newly diagnosed with essential thrombocythemia. The treatment prescribed is peginterferon alfa-2a. So far I have done one treatment and wow does it suck! I haven't seen anyone else talking about this course of treatment. Is anyone else doing this? I sure could use some

Brand new paper from Johannes Dietrich (one of diogenes' group) and others. [i]What is takotsubo cardiomyopathy?[/i] [i]British Heart Foundation[/i] https://www.bhf.org.uk/informationsupport/conditions/cardiomyopathy/takotsubo-cardiomyopathy [i]Takotsubo syndrome outcomes predicted by

My consultant has said I need to start treatment for PV and has asked me to choose between them. I'd really welcome any recommendations. I am new to this site, apologies uf this has been asked before.

Hello everyone, I moved to a new GP in the last few years (house move). When I moved, my doctor just continued prescribing levothyroxine because it was on my records and although he wasn't testing T3 he did look at T4 and seemed to listen to me when I explained the levels I needed to be at, in order