Experiences with

Thyrotropin alfa

   “Our results suggest that a higher initiating-dose regimen, with the flexibility of dose schedule adjustment from biweekly to monthly, i.e., once every 3-5 weeks, after the CHR is stabilized with 1 year of ropeg treatment is associated with a high chance of neoplastic cell clearance and robust clinical

Discussion; The results in our study demonstrate that the new dosing regimen of 250-350-500 µg of ropeginterferon alfa-2b is well-tolerated and highly efficacious in patients suffering from PV. This dosing regimen was associated with a rapid achievement of CHR without the need for phlebotomy or erythrocyte

For the last 60 years I have been a vigilant weight watcher, daily exerciser and have watched my calorie intake. When I commenced treatment for my Essential Thrombocytosis in January 2021, my weight was 53.5kg. Three years later this has ballooned to 60.3kg, despite my efforts to control any

A potentially important issue for some people. And one that is 100% ignored when dentists say we should not rinse after brushing. Even if we do rinse after some time, it is likely that we will swallow some of the calcium ingredients (if our toothpaste contains any). Despite being written as a paediatric

If you search this forum, you can find 52 posts which mention "cataract" - and several gave rise to significant discussions. Search if you wish: https://healthunlocked.com/thyroiduk/search/posts?query=cataract I'm not sure how much "proof" this paper provides of a link. But it certainly points a finger

Like most documents, this has strengths and weaknesses. You might find it easier to follow than some. Though some of it really is quite hard for those not already familiar with thyroid issues. Or more up-to-date (it was published this year - 2024). And it might provide some useful and quotable

A rather disappointing paper. First, the full paper is, as so often, behind a paywall. Also, because the the paper doesn't come out with a clear "Yes, the tests are wonderful and reliable." It is quite clear that there is sufficient uncertainty to question all results from these tests. We have had

Conclusions: High long-term response rates (80.4% at 24 months; 73.2% at 72 months) were achieved with ropeginterferon alfa-2b treatment in the low-risk PV population when the dose was optimized on an individual basis. No specific baseline characteristics among low-risk PV patients appear to be associated

Hi just after some help please. I have had suppressed TSH levels since 2010, apart from a blip in 2014 when it was 2 pmol/l. (range is 0.35 to 4.7. ). My level has been consistently low at 0.02 pmol/l from 2018 to 2024. My T4 has been in range over the years ( 7.8 to 21) however my T3 was raised at

Hola! I'm new to this group and newly diagnosed with essential thrombocythemia. The treatment prescribed is peginterferon alfa-2a. So far I have done one treatment and wow does it suck! I haven't seen anyone else talking about this course of treatment. Is anyone else doing this? I sure could use some

Brand new paper from Johannes Dietrich (one of diogenes' group) and others. [i]What is takotsubo cardiomyopathy?[/i] [i]British Heart Foundation[/i] https://www.bhf.org.uk/informationsupport/conditions/cardiomyopathy/takotsubo-cardiomyopathy [i]Takotsubo syndrome outcomes predicted by

My consultant has said I need to start treatment for PV and has asked me to choose between them. I'd really welcome any recommendations. I am new to this site, apologies uf this has been asked before.

Hello everyone, I moved to a new GP in the last few years (house move). When I moved, my doctor just continued prescribing levothyroxine because it was on my records and although he wasn't testing T3 he did look at T4 and seemed to listen to me when I explained the levels I needed to be at, in order

 »Normal life expectancy may be achievable in PV based on comparable overall survival in interferon-treated patients and a matched US population (p = 0.3), contrasting with shortened survival (p = 0.03) in non-interferon treated patients at the same academic center [3]. Although overall survival was

Of course, research is necessary. We can all make lots of assumptions, guesses, which turn out to be entirely wrong. But this paper does seem to endorse what many here have said. If you are going to become pregnant, that itself will tend to raise TSH levels. If you want to keep below any chosen TSH

I don't usually share info on the internet, but as a lot of material out there is aimed at women or Americans (I mean no offence to either!) I thought I'd stay my experience so far. Diagnosis, what does it all mean, and treatment/first medications. DIAGNOSIS Late 2022 I saw a nurse as I was taking longer

Two New Trials Testing Ropeginterferon (Besremi) in PV and ETMar 3, 2023John Mascarenhas, MDAssociate Professor & Director of the Adult Leukemia Program0 seconds of 8 minutes, 40 secondsDESCRIPTIONTRANSCRIPTDr. Mascarenhas: Hi, I'm John Mascarenhas, a professor of medicine at the Icahn School of Medicine

These first two papers can be used to prove that on T4 monotherapy , a dose that is enough to 'satisfy' the hypothalamus /pituitary (ie. lowers TSH to the bottom end of the ref range) , does not necessarily provide 'enough' T3 to all the other tissues... some other tissues can remain hypothyroid despite

A paper which causes me significant concern. This is my blog which explains, I hope, my deep scepticism about existing prediction of required levothyroxine doses. [i] helvella - Estimation of Levothyroxine Dosing in Adults A discussion about the use of formulas to estimate levothyroxine

Hallux valgus is commonly referred to as a bunion. The paper is complex - but the take-home is that there is a genetic relationship in at least some patients between hallux valgus and hypothyroidism. Another one to add to the list... [i]Causal relationship between thyroid dysfunction and hallux