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How prostate cancer transforms into aggressive NEPC following treatment with anti-androgen therapy.
This could be a game changer as it could stop PCa from progressing. Science is going to save us. The development of effective anti-androgen therapies for prostate cancer is a major scientific advance. However, some men who receive these targeted treatments are more likely to develop a deadly treatment-resistant
This could be a game changer as it could stop PCa from progressing. Science is going to save us. The development of effective anti-androgen therapies for prostate cancer is a major scientific advance. However, some men who receive these targeted treatments are more likely to develop a deadly treatment-resistant
Scout4answers
in
Advanced Prostate Cancer
11 months ago
Selective amino acid restriction therapy (SAART)
This is a follow-on from something that came up in the "
Cysteine depletion sensitizes prostate cancer cells to agents that enhance DNA damage and to immune checkpoint inhibition"
post. Some here may be unfamiliar with the idea of selective amino acid restriction. I have never been tempted to
This is a follow-on from something that came up in the "
Cysteine depletion sensitizes prostate cancer cells to agents that enhance DNA damage and to immune checkpoint inhibition"
post. Some here may be unfamiliar with the idea of selective amino acid restriction. I have never been tempted to
pca2004
in
Fight Prostate Cancer
1 year ago
Discovery of a signaling feedback circuit that defines interferon responses in myeloproliferative neoplasms- Published: 01 April 2022
This gets a little deep, but nonetheless may explain some things:
Abstract
Interferons (IFNs) are key initiators and effectors of the immune response against malignant cells and also directly inhibit tumor growth. IFNα is highly effective in the treatment of myeloproliferative neoplasms (MPNs
This gets a little deep, but nonetheless may explain some things:
Abstract
Interferons (IFNs) are key initiators and effectors of the immune response against malignant cells and also directly inhibit tumor growth. IFNα is highly effective in the treatment of myeloproliferative neoplasms (MPNs
PhysAssist
in
MPN Voice
1 year ago
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Combined Metabolic Activators (CMA) Improve Cognitive Functions without Altering Motor Scores in Parkinson’s Disease 2021
These are the same people that did the Alzheimer's trial PDWarrior1900wrote about: 29% IMPROVEMENT in Alzheimer's using just 4 supplements in Phase 2 Clinical Study https://healthunlocked.com/cure-parkinsons/posts/149233066/29-improvement-in-alzheimer-s-using-just-4-supplements-in-phase-2-clinical-study
These are the same people that did the Alzheimer's trial PDWarrior1900wrote about: 29% IMPROVEMENT in Alzheimer's using just 4 supplements in Phase 2 Clinical Study https://healthunlocked.com/cure-parkinsons/posts/149233066/29-improvement-in-alzheimer-s-using-just-4-supplements-in-phase-2-clinical-study
Bolt_Upright
in
Cure Parkinson's
2 years ago
Irisin reduces AS aggregation
Amelioration of pathologic α-synuclein-induced Parkinson’s disease by irisin Irisin is an exercise-induced polypeptide secreted by skeletal muscle that crosses the blood–brain barrier and mediates certain effects of exercise. Here, we show that irisin prevents pathologic α-synuclein (α-syn)-induced
Amelioration of pathologic α-synuclein-induced Parkinson’s disease by irisin Irisin is an exercise-induced polypeptide secreted by skeletal muscle that crosses the blood–brain barrier and mediates certain effects of exercise. Here, we show that irisin prevents pathologic α-synuclein (α-syn)-induced
Little_apple
in
Cure Parkinson's
2 years ago
” Phosphorylation regulates the a-syn degradation”
Does exogenous AS contribute to endogenous AS? Or is AS, when ingested via dietary consumption denatured or changed in some way making this not an issue? α-Syn undergoes various post-translational modifications, such as phosphorylation, truncation, ubiquitination, and nitration. Phosphorylation
Does exogenous AS contribute to endogenous AS? Or is AS, when ingested via dietary consumption denatured or changed in some way making this not an issue? α-Syn undergoes various post-translational modifications, such as phosphorylation, truncation, ubiquitination, and nitration. Phosphorylation
Little_apple
in
Cure Parkinson's
2 years ago
Indican : elevated urinary indican levels ; proteolytic enzymes potentially reduce indican levels
Elevated urinary indican levels are associated with PD. https://pubmed.ncbi.nlm.nih.gov/25707302/ Urinary indican is a indicator of decreased protein digestion. Could digestive enzymes (protease) help reduce indican? indican lab tests available https://www.ultalabtests.com/test/indican-urine
Elevated urinary indican levels are associated with PD. https://pubmed.ncbi.nlm.nih.gov/25707302/ Urinary indican is a indicator of decreased protein digestion. Could digestive enzymes (protease) help reduce indican? indican lab tests available https://www.ultalabtests.com/test/indican-urine
Little_apple
in
Cure Parkinson's
2 years ago
Update on Mayo visit
UPDATE regarding my Mayo visit. So excited and fascinated by this hopsital/clinic!! Not sure if being excited about finding more issues is good or not...but I am! I finally have some answers that make sense. Here goes.... The week included blood, urine tests, chest xray, holter monitor, loop recorder
UPDATE regarding my Mayo visit. So excited and fascinated by this hopsital/clinic!! Not sure if being excited about finding more issues is good or not...but I am! I finally have some answers that make sense. Here goes.... The week included blood, urine tests, chest xray, holter monitor, loop recorder
Mermaidatheart
in
Hughes Syndrome APS Forum
2 years ago
Discovery of a signaling feedback circuit that defines interferon responses in MPN
« Interferons (IFNs) are key initiators and effectors of the immune response against malignant cells and also directly inhibit tumor growth. IFNα is highly effective in the treatment of myeloproliferative neoplasms (MPNs), but the mechanisms of action are unclear and it remains unknown why some patients
« Interferons (IFNs) are key initiators and effectors of the immune response against malignant cells and also directly inhibit tumor growth. IFNα is highly effective in the treatment of myeloproliferative neoplasms (MPNs), but the mechanisms of action are unclear and it remains unknown why some patients
Manouche
in
MPN Voice
2 years ago
Bromhexine, an over-the-counter mucolytic drug, suppresses the growth and metastasis of prostate tumors
Abstract TMPRSS2 is an androgen-regulated cell-surface serine protease expressed predominantly in prostate epithelium that is involved in the viral entry and spread of COVID-19. TMPRSS2 is expressed highly in localized high-grade prostate cancers and in the majority of human prostate cancer metastases
Abstract TMPRSS2 is an androgen-regulated cell-surface serine protease expressed predominantly in prostate epithelium that is involved in the viral entry and spread of COVID-19. TMPRSS2 is expressed highly in localized high-grade prostate cancers and in the majority of human prostate cancer metastases
Hidden
in
Advanced Prostate Cancer
2 years ago
A Wise Person Told Me to Not Forget About TUDCA
Bile Acid Signaling in Neurodegenerative and Neurological Disorders 2020 https://mdpi-res.com/d_attachment/ijms/ijms-21-05982/article_deploy/ijms-21-05982.pdf "4.2. Parkinson’s Disease After AD, Parkinson’s disease (PD) is the second most common neurodegenerative disease marked by progressive motor deterioration
Bile Acid Signaling in Neurodegenerative and Neurological Disorders 2020 https://mdpi-res.com/d_attachment/ijms/ijms-21-05982/article_deploy/ijms-21-05982.pdf "4.2. Parkinson’s Disease After AD, Parkinson’s disease (PD) is the second most common neurodegenerative disease marked by progressive motor deterioration
Bolt_Upright
in
Cure Parkinson's
3 years ago
The Neuroendocrine Connection
Adrenal hormones, sex hormones, and neurotransmitters are functionally interrelated. Changes in sex hormones and adrenal hormones can lead to neurotransmitter imbalances. In turn, neurotransmitter imbalances can affect hormone function. The following tests are recommended to establish your baseline.
Adrenal hormones, sex hormones, and neurotransmitters are functionally interrelated. Changes in sex hormones and adrenal hormones can lead to neurotransmitter imbalances. In turn, neurotransmitter imbalances can affect hormone function. The following tests are recommended to establish your baseline.
SilentEchoes
in
Cure Parkinson's
3 years ago
Anyone tried serzone or nefazodone?
Long term effects may cause liver damage. Anyone have experience with this med?
Long term effects may cause liver damage. Anyone have experience with this med?
samack
in
Anxiety and Depression Support
3 years ago
A new trial suggests that a combination of NAC, Nicotinamide Riboside, Serine, and Carnitine will improve the cognitive performance of PD
Brad Stanfield, MD Aug 15, 2021 A new trial suggests that a combination of NAC, Nicotinamide Riboside, Serine, and Carnitine will improve the cognitive performance of Parkinson's Disease patients. https://youtu.be/ensRh8sR5ik Link to the new trial: https://www.medrxiv.org/content/10.1101/2021.07.28.21261293v1
Brad Stanfield, MD Aug 15, 2021 A new trial suggests that a combination of NAC, Nicotinamide Riboside, Serine, and Carnitine will improve the cognitive performance of Parkinson's Disease patients. https://youtu.be/ensRh8sR5ik Link to the new trial: https://www.medrxiv.org/content/10.1101/2021.07.28.21261293v1
Bolt_Upright
in
Cure Parkinson's
3 years ago
Interesting looking supplement
Saw this one on a dental summit. Used to detox and other things. Has a lot of familiar ingredients! Has anyone used it? https://oradix.com/product/stemdetox-detoxification-anti-germ-and-weight-loss/ How to Use StemDetox™ Take 1 capsule 2X daily for the 1st 5 days, 3 capsules 2X daily for the next 5
Saw this one on a dental summit. Used to detox and other things. Has a lot of familiar ingredients! Has anyone used it? https://oradix.com/product/stemdetox-detoxification-anti-germ-and-weight-loss/ How to Use StemDetox™ Take 1 capsule 2X daily for the 1st 5 days, 3 capsules 2X daily for the next 5
LAJ12345
in
Cure Parkinson's
3 years ago
Pancreas- It's Role in Human Digestive system every diabetes should know & Top Healthy Foods for a Healthy Pancreas.
Please read the entire post to get the right Perspective. Have a look at the Image of our wonderfully looking Pancreas and it's location in human body in the attached image above. When we talk of Pancreas, we quickly relate it with production of Insulin. But you would be surprised to note that
Please read the entire post to get the right Perspective. Have a look at the Image of our wonderfully looking Pancreas and it's location in human body in the attached image above. When we talk of Pancreas, we quickly relate it with production of Insulin. But you would be surprised to note that
namaha
Administrator
in
Diabetes India
3 years ago
Reduced Carb Diet and a Little Weight Loss is Reducing My Blood Lipids and Liver Inflammation Markers
I just thought I'd share my findings, maybe it'll help encourage those struggling with carbohydrate reduction and a change in diet. For the past 6 weeks i have been restricting carbohydrates (to around 100ish grams per day), with the complete elimination of added sucrose or foods containing sucrose as
I just thought I'd share my findings, maybe it'll help encourage those struggling with carbohydrate reduction and a change in diet. For the past 6 weeks i have been restricting carbohydrates (to around 100ish grams per day), with the complete elimination of added sucrose or foods containing sucrose as
DBradley
in
Living with Fatty Liver and NASH
3 years ago
Scientists identify protein that could serve as a therapeutic target in lung cancer.
Scientists at VCU Massey Cancer Center have identified a protein that operates in tandem with a specific genetic mutation to spur lung cancer growth and could serve as a therapeutic target to treat the disease. Mutations in the p53 gene are found in more than half of all cancers, but it remains difficult
Scientists at VCU Massey Cancer Center have identified a protein that operates in tandem with a specific genetic mutation to spur lung cancer growth and could serve as a therapeutic target to treat the disease. Mutations in the p53 gene are found in more than half of all cancers, but it remains difficult
2greys
in
Lung Conditions Community Forum
3 years ago
Can PD get better?
A DAT scan shows I have PD. I take Rytary but Dr Google suggests other meds might help. So I also take cinnamon, phosphatidyl serine, Super B-complex, Vitamin D, Green tea capsules, fish oil, a statin, CoQ10, baby aspirin, miralax, dulcolax, tylenol and melatonin. Some of these are for PD
A DAT scan shows I have PD. I take Rytary but Dr Google suggests other meds might help. So I also take cinnamon, phosphatidyl serine, Super B-complex, Vitamin D, Green tea capsules, fish oil, a statin, CoQ10, baby aspirin, miralax, dulcolax, tylenol and melatonin. Some of these are for PD
kaypeeoh
in
Cure Parkinson's
3 years ago
The more homocysteine, the worse the Parkinson's?
"You don't discover new continents if you don't have the courage to lose sight of the old shores." Andre Gide An elevated level of the amino acid homocysteine in the blood is neurotoxic and has been reported as a truly important risk factor for developing Parkinson's, as well as cardiovascular disease
"You don't discover new continents if you don't have the courage to lose sight of the old shores." Andre Gide An elevated level of the amino acid homocysteine in the blood is neurotoxic and has been reported as a truly important risk factor for developing Parkinson's, as well as cardiovascular disease
parkinsonshereandnow
in
Cure Parkinson's
4 years ago
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