Indican : elevated urinary indican levels ; proteolytic enzymes potentially reduce indican levels

[Little_apple]

Elevated urinary indican levels are associated with PD.

pubmed.ncbi.nlm.nih.gov/257...

Urinary indican is a indicator of decreased protein digestion. Could digestive enzymes (protease) help reduce indican?

indican lab tests available

ultalabtests.com/test/indic...

Proteolytic clearance of extracellular α-synuclein as a new therapeutic approach against Parkinson disease

ncbi.nlm.nih.gov/pmc/articl...

“Preventing the spread of extracellular α-syn may be a suitable means of halting the progression of PD. The level of extracellular α-syn depends both on the rate of α-syn release from neuronal cells and the rate of its removal through various clearance pathways such as cell-mediated clearance, proteolytic degradation, chaperone-mediated clearance and active/passive transport out of the brain. Therefore, the treatment of PD could be achieved through targeting the regulation of α-syn release and uptake, or the removal of extracellular α-syn by a variety of clearance systems.Proteolytic clearance is possible using any of several proteases that have been identified to be able to cleave and degrade α-syn: these include neurosin,55 matrix metalloproteinases (MMPs),56calpain,57 cathepsin D58 and plasmin.59 Among them, neurosin, MMPs and plasmin have been reported to cleave and degrade extracellular α-syn. Neurosin, a serine protease, is preferentially expressed in neurons and oligodendrocytes in the brain.55 It was first observed to be colocalized in some senile plaques in AD patients as well as Lewy bodies in PD patients.60 It has also been reported to degrade intracellular α-syn, but less efficiently A53T α-syn and als”

[Little_apple]

maybe increasing enzymes is NOT the right course. But how can we encourage them to pass through via feces instead of putrifying as indicated by the elevated indican levels.

michaeljfox.org/grant/speci...